A Unique Example of Drug Metabolism: Tetra- and Penta-Oxygenation Reactions of Capravirine in Rats, Dogs and Humans

Hai-Zhi Bu; William F. Pool; Ellen Y. Wu; Bhasker V. Shetty

doi:10.2174/187231207779814373

ISSN: 1872-3128
E-ISSN: 1874-0758

A Unique Example of Drug Metabolism: Tetra- and Penta-Oxygenation Reactions of Capravirine in Rats, Dogs and Humans
Authors: Hai-Zhi Bu¹, William F. Pool², Ellen Y. Wu³ and Bhasker V. Shetty⁴
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¹ Department of Pharmacokinetics,Dynamics and Metabolism, PGRD, San Diego, CA 92121, USA. ² Department of Pharmacokinetics,Dynamics and Metabolism, PGRD, San Diego, CA 92121, USA. ³ Department of Pharmacokinetics,Dynamics and Metabolism, PGRD, San Diego, CA 92121, USA. ⁴ Department of Pharmacokinetics,Dynamics and Metabolism, PGRD, San Diego, CA 92121, USA.
Source: Drug Metabolism Letters, Volume 1, Issue 1, Jan 2007, p. 61 - 65
DOI: https://doi.org/10.2174/187231207779814373
- Available online: 01 Jan 2007

Abstract

Six tetra- and two penta-oxygenated capravirine metabolites observed in rats, dogs and humans represent the maximum numbers of isomers that can be predicted since oxygenations are restricted at the pyridinyl nitrogen (Noxidation), sulfur (sulfoxidation), and isopropyl group (hydroxylation), exemplifying a unique case that is very unusual for sequential drug metabolism.

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2007-01-01

2025-10-01

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Article Type: Research Article

Keyword(s): biotransformation; Capravirine; identification; metabolism; oxygenation; profiling; structure elucidation

A Unique Example of Drug Metabolism: Tetra- and Penta-Oxygenation Reactions of Capravirine in Rats, Dogs and Humans

Abstract

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