A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis

Akira Abe; Miki Hiraoka; James A. Shayman

doi:10.2174/187231207779814292

ISSN: 1872-3128
E-ISSN: 1874-0758

A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis
Authors: Akira Abe¹, Miki Hiraoka² and James A. Shayman³
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¹ University of Michigan Medical Center, Department of Internal Medicine, Division of Nephrology,Room 1560 MRRB II, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0676, USA. ² University of Michigan Medical Center, Department of Internal Medicine, Division of Nephrology,Room 1560 MRRB II, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0676, USA. ³ University of Michigan Medical Center, Department of Internal Medicine, Division of Nephrology,Room 1560 MRRB II, 1150 West Medical Center Drive, Ann Arbor, MI 48109-0676, USA.
Source: Drug Metabolism Letters, Volume 1, Issue 1, Jan 2007, p. 49 - 53
DOI: https://doi.org/10.2174/187231207779814292
- Available online: 01 Jan 2007

Abstract

Many therapeutic drugs currently in use are cationic amphiphiles. These cationic amphiphilic drugs (CADs) induce phospholipidosis in humans and experimental animals. The recent study shows that CAD-induced cellular phospholipidosis is linked to the impairment of phospholipid catabolism by inhibition of lysosomal phospholipase A2 activity.

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2007-01-01

2025-10-01

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Article Type: Research Article

Keyword(s): amiodarone; Cationic amphiphilic drug; lysosomal phospholipase A2; PDMP; phospholipidosis; tetracycline

A Role for Lysosomal Phospholipase A2 in Drug Induced Phospholipidosis

Abstract

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