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An article of this issue show how a clinical practice has been universally introduced without any scientific evidence, based only on opinions and soon after its introduction, well designed clinical trials showed that this practice is useless and also deleterious. This is a paradigmatic example on how we should not proceed and the need of the critical analysis of available research to give support to our daily practice. The objective of the Journal is to provide scientific evidences on initial care required for women's health related problems. The diversity of the articles of this issue shows us that how fascinating is the search for the evidences and how we need research to advance our achievements. For instance, probiotics looks as a very promising approach for the treatment of infections and the author of this article shows us not only its potential but also the willingness and need of clinical trials to assess it efficacy and further implementation. Many paradigmatic experiences show us that only the knowledge of the physiopathology of a drug and clinical experience are not enough to highlight the efficacy and safety of a drug. This is the dramatic example of the use of diethylstilbestrol that was implemented without any scientific evidence and further careful research demonstrated its harm and lack of any benefit in issues concerning pregnancy. On the other hand, researchers guided by an observation in animals for a potential benefit of maternal corticosteroids administered in humans in a randomised controlled trial and demonstrated the benefits of such a treatment without major harmful effects. Since then, this treatment has played a significant role in saving lives of many children. In this context, we need that every new proposal of treatment, diagnostic or prognostic method should be strictly evaluated by proficient research. Also, to be aware that fortunately research provides us new evidences that bring about changes in the practise incorporated in our early stages of training. To be the best providers, we should accept such changes and incorporate new findings or discontinue the use of practices demonstrated as useless. In this context, we should not be attracted by the propaganda of new and sophisticated technologies and should not implement them before being confident about their benefit. A rationale use of the scarce resources on health care is also the concern of providers. A scientific Journal is a fascinating world where the advancements and the challenges are set. The aim here is to attain a better quality of care to women, and provide them the best quality of life.