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2000
Volume 21, Issue 6
  • ISSN: 1573-4048
  • E-ISSN: 1875-6581

Abstract

Background

Quercetin (QT) is an effective plant compound in treating various diseases, including certain types of cancer. Therefore, this systematic review study was conducted to investigate the positive effects of quercetin (QT) on different breast cancer cell lines under conditions.

Objective

The purpose of this study was to explore the beneficial effects of quercetin (QT) on various breast cancer cell lines in an setting.

Methods

Using various databases, including PubMed, Scopus, Science Direct, and Google Scholar, we searched for publications from 2018 to May 2024 based on relevant terms and keywords for this systematic review. Inclusion criteria focused on English, open access, and original studies that exclusively examined the effects of QT on breast cancer cell types .

Results

From the initial search, 1308 publications were identified. However, only 46 met the inclusion criteria and were included in this systematic review.

Conclusion

In summary, quercetin (QT) shows anti-tumor effects on different breast cancer cell lines by activating the PI3K/AKT/mTOR, IGF1/IGF1R, MAPK, Transforming Growth Factor-β (TGFβ), and JAK/STAT1 pathways. Nonetheless, further extensive animal and clinical studies are essential to draw definitive conclusions.

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Therapeutic Targeting of Quercetin Only to Breast Cancer Cells under In Vitro Conditions: A Systematic Review
Curr Womens Health Rev. 21, e15734048332611 (2025); https://doi.org/10.2174/0115734048332611250106075111
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  • Article Type:     Review Article
Keyword(s): anti-tumor effects; Anticancer; breast cancer; in vitro; quercetin; transforming growth factor-β (TGFβ)

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