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2000
Volume 8, Issue 6
  • ISSN: 1570-1611
  • E-ISSN: 1875-6212

Abstract

The 3-hydroxy-3-methyl-glutaryl-CoA (HMG-CoA) reductase inhibitors (statins) are a class of drug used to lower low-density lipoprotein (LDL) levels. However, in recent years, statins have been shown to possess a pleiotropic effect beyond its cholesterol lowering ability, including attenuating the effect of ischaemia reperfusion injury. This review considers the biomolecular processes that may lead to this beneficial effect.

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/content/journals/cvp/10.2174/157016110793563780
2010-11-01
2025-10-04

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  • Article Type:     Research Article
Keyword(s): 3-hydroxy-3-methyl-glutaryl-CoA; activator protein-1; angioplasty; atorvastatin; C-reactive protein; cerivastatin; cholesterol biosynthesis; coronary heart disease; cytochrome P450; cytokine transcription; cytokines; decay-accelerating factor; endothelial dysfunction; endothelial NO synthase; endothelin-1; fluvastatin; hypoxanthine; inducible NO synthase; inflammatory re-sponse syndrome; inter-leukin (IL)-1; Ischaemia reperfusion injury; Leukocytes-Endothelial Interaction; lovastatin; low-density lipoprotein; monocyte chemoattractant protein-1/kwd> thrombomodulin; multi organs dysfunction syn-drome; NADPH-oxidase; neuronal NO synthase; nitric oxide; nuclear factor B; PAF receptor; platelet-activating factor; pravastatin; Pro-Inflammatory Cytokines; protein kinase C; reactive oxygen species; reductase inhibitors; rhabdo-myolysis; ROS reduction; rosuvastatin; sialyl Lewis X; simvastatin; statins; thrombin; tissue hypoxia; tumour necrosis factor alpha; vascular endothelial cadherin; xanthine oxidase

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