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2000
Volume 23, Issue 6
  • ISSN: 1570-1611
  • E-ISSN: 1875-6212

Abstract

Traditionally, arterial atherosclerosis (AA) and venous thromboembolic (VTE) diseases have been separated into two independent entities. However, a body of evidence suggests the link between arterial and venous disease. In this narrative review, the relationship between these two vascular diseases is discussed. Different risk factors are common in both diseases, such as dyslipidaemia, metabolic syndrome, and thrombophilia. Etiopathogenetic mechanisms of both diseases are similar. Inflammation, as a basic pathogenetic mechanism of arterial atherosclerosis, is also involved in the pathogenesis of VTE. Inflammation as a response to vessel wall injury promotes coagulation and inhibits endogenic fibrinolytic activity, which results in thromboembolic events in the arterial as well as in the venous system. A relationship has also been observed between preclinical or clinical arterial atherosclerosis and VTE. These findings indicate that atherosclerosis may induce VTE or that common risk factors simultaneously stimulate the development of both diseases. The relationship between arterial and venous disease is also supported by the efficacy of some drugs (antiplatelets, anticoagulants, statins) in the prevention of both diseases.

In conclusion, arterial and venous diseases share similar pathophysiological mechanisms, often driven by common risk factors. This overlap suggests that a unified approach to prevention and treatment may be beneficial for both conditions, potentially improving patient outcomes by addressing the underlying shared pathways.

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2025-11-01
2025-12-15

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References

  1. PrandoniP. Links between arterial and venous disease.J. Intern. Med.2007262334135010.1111/j.1365‑2796.2007.01815.x 17697155
     [Google Scholar]
  2. PrandoniP. BiloraF. MarchioriA. An association between atherosclerosis and venous thrombosis.N. Engl. J. Med.2003348151435144110.1056/NEJMoa022157 12686699
     [Google Scholar]
  3. NogueiraJ.F.L. Teixeira-VianaF.C. Barboza-SilvaB.L. Mendes-PintoD. Rodrigues-MachadoM.G. Advanced Levels of Chronic Venous Insufficiency are Related to an Increased in Arterial Stiffness.Ann. Vasc. Surg.20239636537310.1016/j.avsg.2023.03.013 37003361
     [Google Scholar]
  4. AuzkyO. LanskaV. PithaJ. RoztocilK. Association between symptoms of chronic venous disease in the lower extremities and cardiovascular risk factors in middle-aged women.Int. Angiol.2011304335341 21747352
     [Google Scholar]
  5. AngchaisuksiriP. Arterial and venous thrombosis: shared risk factors and pathophysiology.J Hematol Transfus Med201929355362
     [Google Scholar]
  6. CroceK. LibbyP. Intertwining of thrombosis and inflammation in atherosclerosis.Curr. Opin. Hematol.2007141556110.1097/00062752‑200701000‑00011 17133101
     [Google Scholar]
  7. JezovnikM.K. FareedJ. PoredosP. Patients With a History of Idiopathic Deep Venous Thrombosis Have Long-Term Increased Levels of Inflammatory Markers and Markers of Endothelial Damage.Clin. Appl. Thromb. Hemost.201723212413110.1177/1076029616670259 27663463
     [Google Scholar]
  8. KongP. CuiZ.Y. HuangX.F. ZhangD.D. GuoR.J. HanM. Inflammation and atherosclerosis: signaling pathways and therapeutic intervention.Signal Transduct. Target. Ther.20227113110.1038/s41392‑022‑00955‑7 35459215
     [Google Scholar]
  9. PoredosP. JezovnikM.K. In patients with idiopathic venous thrombosis, interleukin-10 is decreased and related to endothelial dysfunction.Heart Vessels201126659660210.1007/s00380‑010‑0111‑3 21267581
     [Google Scholar]
  10. Del CondeI. LópezJ.A. Classification of venous thromboembolism (VTE).J. Thromb. Haemost.20053112573257510.1111/j.1538‑7836.2005.01660.x 16241956
     [Google Scholar]
  11. EsmonC.T. Inflammation and thrombosis.J. Thromb. Haemost.2003171343134810.1046/j.1538‑7836.2003.00261.x 12871267
     [Google Scholar]
  12. BurzynskiL.C. HumphryM. PyrillouK. The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin.Immunity201950410331042.e610.1016/j.immuni.2019.03.003 30926232
     [Google Scholar]
  13. CollenD. HoylaertsM.F. Relationship between inflammation and venous thromboembolism as studied by microparticle assessment in plasma.J. Am. Coll. Cardiol.20054591472147310.1016/j.jacc.2005.02.029 15862421
     [Google Scholar]
  14. PoredošP. Interrelationship between venous and arterial thrombosis.Int. Angiol.201736429529810.23736/S0392‑9590.17.03820‑2 28263045
     [Google Scholar]
  15. MiliF.D. Family history of myocardial infarction is a risk factor for venous thromboembolism among whites but not among blacks.Clin. Appl. Thromb. Hemost.2013194410417
     [Google Scholar]
  16. LassilaR. Role and management of coagulation disorders in peripheral arterial disease.Scand. J. Surg.20121012949910.1177/145749691210100204
     [Google Scholar]
  17. KellerK. ProchaskaJ.H. ColdeweyM. Atherosclerosis and Its Impact on the Outcomes of Patients with Deep Venous Thrombosis.Life (Basel)202212573410.3390/life12050734 35629401
     [Google Scholar]
  18. FalkE. ThuesenL. Pathology of coronary microembolisation and no reflow.Heart200389998398510.1136/heart.89.9.983
     [Google Scholar]
  19. LibertinyG. HandsL. Deep venous thrombosis in peripheral vascular disease.Br. J. Surg.199986790791010.1046/j.1365‑2168.1999.01129.x 10417563
     [Google Scholar]
  20. SykoraD. FirthC. GirardoM. Peripheral artery disease and the risk of venous thromboembolism.Vasa202251636537110.1024/0301‑1526/a001029 36134738
     [Google Scholar]
  21. TripodiA. BranchiA. ChantarangkulV. Hypercoagulability in patients with type 2 diabetes mellitus detected by a thrombin generation assay.J. Thromb. Thrombolysis201131216517210.1007/s11239‑010‑0506‑0 20640482
     [Google Scholar]
  22. PrevitaliE. BucciarelliP. PassamontiS.M. MartinelliI. Risk factors for venous and arterial thrombosis.Blood Transfus.201192120138 21084000
     [Google Scholar]
  23. MariD. OgliariG. CastaldiD. VitaleG. BolliniE.M. LioD. Hemostasis and ageing.Immun. Ageing2008511210.1186/1742‑4933‑5‑12 18947391
     [Google Scholar]
  24. KannelW.B. WolfP.A. CastelliW.P. D’AgostinoR.B. Fibrinogen and risk of cardiovascular disease. The Framingham Study.JAMA198725891183118610.1001/jama.1987.03400090067035 3626001
     [Google Scholar]
  25. GleerupG. WintherK. The effect of ageing on platelet function and fibrinolytic activity.Angiology199546871571810.1177/000331979504600810 7639418
     [Google Scholar]
  26. FranchiniM. TargherG. MontagnanaM. LippiG. The metabolic syndrome and the risk of arterial and venous thrombosis.Thromb. Res.2008122672773510.1016/j.thromres.2007.09.010 17996282
     [Google Scholar]
  27. StubblefieldW.B. AlvesN.J. RondinaM.T. KlineJ.A. Variable Resistance to Plasminogen Activator Initiated Fibrinolysis for Intermediate-Risk Pulmonary Embolism.PLoS One2016112e014874710.1371/journal.pone.0148747 26866684
     [Google Scholar]
  28. MorelS. KwakB. Rohner-JeanrenaudF. SteffensS. MolicaF. Adipokines at the crossroad between obesity and cardiovascular disease.Thromb. Haemost.2015113355356610.1160/TH14‑06‑0513 25338625
     [Google Scholar]
  29. AgenoW. BecattiniC. BrightonT. SelbyR. KamphuisenP.W. Cardiovascular risk factors and venous thromboembolism: a meta-analysis.Circulation200811719310210.1161/CIRCULATIONAHA.107.709204 18086925
     [Google Scholar]
  30. ChengY.J. LiuZ.H. YaoF.J. Current and former smoking and risk for venous thromboembolism: a systematic review and meta-analysis.PLoS Med.2013109e100151510.1371/journal.pmed.1001515 24068896
     [Google Scholar]
  31. PompE.R. RosendaalF.R. DoggenC.J.M. Smoking increases the risk of venous thrombosis and acts synergistically with oral contraceptive use.Am. J. Hematol.20088329710210.1002/ajh.21059 17726684
     [Google Scholar]
  32. MessnerB. BernhardD. Smoking and cardiovascular disease: mechanisms of endothelial dysfunction and early atherogenesis.Arterioscler. Thromb. Vasc. Biol.201434350951510.1161/ATVBAHA.113.300156 24554606
     [Google Scholar]
  33. PoredošP. MukherjeeD. BlincA. Statins and Venous Thromboembolic Disease – Where are we Now?Curr. Vasc. Pharmacol.202422429730010.2174/0115701611308323240229050237 38441024
     [Google Scholar]
  34. MorelliV.M. LijferingW.M. BosM.H.A. RosendaalF.R. CannegieterS.C. Lipid levels and risk of venous thrombosis: results from the MEGA-study.Eur. J. Epidemiol.201732866968110.1007/s10654‑017‑0251‑1 28540474
     [Google Scholar]
  35. DeguchiH. PecheniukN.M. EliasD.J. AverellP.M. GriffinJ.H. High-density lipoprotein deficiency and dyslipoproteinemia associated with venous thrombosis in men.Circulation2005112689389910.1161/CIRCULATIONAHA.104.521344 16087810
     [Google Scholar]
  36. HuangY. GeH. WangX. ZhangX. Association Between Blood Lipid Levels and Lower Extremity Deep Venous Thrombosis: A Population-Based Cohort Study.Clin. Appl. Thromb. Hemost.2022281076029622112128210.1177/10760296221121282 36189865
     [Google Scholar]
  37. GlynnR.J. DanielsonE. FonsecaF.A.H. A randomized trial of rosuvastatin in the prevention of venous thromboembolism.N. Engl. J. Med.2009360181851186110.1056/NEJMoa0900241 19329822
     [Google Scholar]
  38. PoredosP. JezovnikM.K. Dyslipidemia, statins, and venous thromboembolism.Semin. Thromb. Hemost.201137889790210.1055/s‑0031‑1297368 22198854
     [Google Scholar]
  39. Quist-PaulsenP. NaessI.A. CannegieterS.C. Arterial cardiovascular risk factors and venous thrombosis: results from a population-based, prospective study (the HUNT 2).Haematologica201095111912510.3324/haematol.2009.011866 19713225
     [Google Scholar]
  40. PetrauskieneV. FalkM. WaernbaumI. NorbergM. ErikssonJ.W. The risk of venous thromboembolism is markedly elevated in patients with diabetes.Diabetologia20054851017102110.1007/s00125‑005‑1715‑5 15778859
     [Google Scholar]
  41. NazarzadehM. BidelZ. MohseniH. Blood pressure and risk of venous thromboembolism: a cohort analysis of 5.5 million UK adults and Mendelian randomization studies.Cardiovasc. Res.2023119383584210.1093/cvr/cvac135 36031541
     [Google Scholar]
  42. Di MinnoM.N.D. AmbrosinoP. AgenoW. RosendaalF. Di MinnoG. DentaliF. Natural anticoagulants deficiency and the risk of venous thromboembolism: a meta-analysis of observational studies.Thromb. Res.2015135592393210.1016/j.thromres.2015.03.010 25784135
     [Google Scholar]
  43. ArachchillageD.J. MackillopL. ChandrathevaA. MotawaniJ. MacCallumP. LaffanM. Thrombophilia testing: A British Society for Haematology guideline.Br. J. Haematol.2022198344345810.1111/bjh.18239 35645034
     [Google Scholar]
  44. KimR.J. BeckerR.C. Association between factor V Leiden, prothrombin G20210A, and methylenetetrahydrofolate reductase C677T mutations and events of the arterial circulatory system: a meta-analysis of published studies.Am. Heart J.2003146694895710.1016/S0002‑8703(03)00519‑2 14660985
     [Google Scholar]
  45. HamedaniA.G. ColeJ.W. MitchellB.D. KittnerS.J. Meta-analysis of factor V Leiden and ischemic stroke in young adults: the importance of case ascertainment.Stroke20104181599160310.1161/STROKEAHA.110.581256 20616326
     [Google Scholar]
  46. ChiasakulT. De JesusE. TongJ. Inherited Thrombophilia and the Risk of Arterial Ischemic Stroke: A Systematic Review and Meta‐Analysis.J. Am. Heart Assoc.2019819e01287710.1161/JAHA.119.012877 31549567
     [Google Scholar]
  47. Ken-DrorG. CooperJ.A. HumphriesS.E. DrenosF. IrelandH.A. Free protein S level as a risk factor for coronary heart disease and stroke in a prospective cohort study of healthy United Kingdom men.Am. J. Epidemiol.2011174895896810.1093/aje/kwr203 21911828
     [Google Scholar]
  48. SørensenH.T. Horvath-PuhoE. PedersenL. BaronJ.A. PrandoniP. Venous thromboembolism and subsequent hospitalisation due to acute arterial cardiovascular events: a 20-year cohort study.Lancet200737096011773177910.1016/S0140‑6736(07)61745‑0 18037081
     [Google Scholar]
  49. KnightR. WalkerV. IpS. Association of COVID-19 With Major Arterial and Venous Thrombotic Diseases: A Population-Wide Cohort Study of 48 Million Adults in England and Wales.Circulation20221461289290610.1161/CIRCULATIONAHA.122.060785 36121907
     [Google Scholar]
  50. KarakasisP. NasoufidouA. SagrisM. FragakisN. TsioufisK. Vascular Alterations Following COVID-19 Infection: A Comprehensive Literature Review.Life (Basel)202414554510.3390/life14050545 38792566
     [Google Scholar]
  51. SemeraroN. ColucciM. The Prothrombotic State Associated with SARS-CoV-2 Infection: Pathophysiological Aspects.Mediterr. J. Hematol. Infect. Dis.2021131e202104510.4084/MJHID.2021.045 34276914
     [Google Scholar]
  52. KyriakoulisK.G. KolliasA. KyriakoulisI.G. Thromboprophylaxis in Patients with COVID-19: Systematic Review of National and International Clinical Guidance Reports.Curr. Vasc. Pharmacol.20222019611010.2174/1570161119666210824160332 34431465
     [Google Scholar]
  53. LiJ. LiY. WangZ. LiuN. HeL. ZhangH. Increased risk of new-onset diabetes in patients with COVID-19: a systematic review and meta-analysis.Front. Public Health202311117015610.3389/fpubh.2023.1170156 37304092
     [Google Scholar]
  54. JungH.S. ChoiJ.W. Association between COVID-19 and incidence of cardiovascular disease and all-cause mortality among patients with diabetes.Front. Endocrinol. (Lausanne)202314123017610.3389/fendo.2023.1230176 37576978
     [Google Scholar]
  55. CalvisiS.L. RamirezG.A. ScaviniM. Thromboembolism risk among patients with diabetes/stress hyperglycemia and COVID-19.Metabolism202112315484510.1016/j.metabol.2021.154845 34364927
     [Google Scholar]
  56. Pantea StoianA. BicaI.C. SalmenT. New-Onset Diabetes Mellitus in COVID-19: A Scoping Review.Diabetes Ther.2024151336010.1007/s13300‑023‑01465‑7 37751143
     [Google Scholar]
  57. BecattiniC. AgnelliG. PrandoniP. A prospective study on cardiovascular events after acute pulmonary embolism.Eur. Heart J.2005261778310.1093/eurheartj/ehi018 15615803
     [Google Scholar]
  58. PrandoniP. GhirarduzziA. PrinsM.H. Venous thromboembolism and the risk of subsequent symptomatic atherosclerosis.J. Thromb. Haemost.2006491891189610.1111/j.1538‑7836.2006.02058.x 16961597
     [Google Scholar]
  59. JezovnikM.K. PoredosP. LusaL. Idiopathic venous thrombosis is associated with preclinical atherosclerosis.J. Atheroscler. Thromb.201017330431110.5551/jat.3079 20103975
     [Google Scholar]
  60. JezovnikM.K. PoredosP. StalcM. Impairment of the vasodilatation capability of the brachial artery in patients with idiopathic venous thrombosis.J. Atheroscler. Thromb.201017111190119810.5551/jat.4960 20702975
     [Google Scholar]
  61. JerajL. SpirkoskaA. JežovnikM.K. PoredošP. Deep vein thrombosis and properties of the arterial wall.Vasa201847319720210.1024/0301‑1526/a000695 29485363
     [Google Scholar]
  62. PoredosP. JezovnikM. Enlargement of the diameter of the peripheral arteries in patients with idiopathic venous thrombosis.Ultraschall Med.2011337E268E27410.1055/s‑0031‑1273471 21863540
     [Google Scholar]
  63. HongC. ZhuF. DuD. PilgramT. SicardG. BaeK. Coronary artery calcification and risk factors for atherosclerosis in patients with venous thromboembolism.Atherosclerosis2005183116917410.1016/j.atherosclerosis.2005.03.047 15939424
     [Google Scholar]
  64. GradyD. WengerN.K. HerringtonD. Postmenopausal hormone therapy increases risk for venous thromboembolic disease. The Heart and Estrogen/progestin Replacement Study.Ann. Intern. Med.2000132968969610.7326/0003‑4819‑132‑9‑200005020‑00002 10787361
     [Google Scholar]
  65. SpencerF.A. GinsbergJ.S. ChongA. AlterD.A. The relationship between unprovoked venous thromboembolism, age, and acute myocardial infarction.J. Thromb. Haemost.2008691507151310.1111/j.1538‑7836.2008.03062.x 18624983
     [Google Scholar]
  66. MäkivaaraL.A. AhtiT.M. LuukkaalaT. HakamaM. LaurikkaJ.O. Persons with varicose veins have a high subsequent incidence of arterial disease: a population-based study in Tampere, Finland.Angiology200758670470910.1177/0003319707299202 18216380
     [Google Scholar]
  67. MaticM. MaticA. DjuranV. GajinovZ. PrcicS. GolusinZ. Frequency of Peripheral Arterial Disease in Patients With Chronic Venous Insufficiency.Iran. Red Crescent Med. J.2016181e2078110.5812/ircmj.20781 26889387
     [Google Scholar]
  68. EliassonÅ. BergqvistD. BjörckM. AcostaS. SternbyN.H. ÖgrenM. Incidence and risk of venous thromboembolism in patients with verified arterial thrombosis: a population study based on 23 796 consecutive autopsies.J. Thromb. Haemost.2006491897190210.1111/j.1538‑7836.2006.02152.x 16881933
     [Google Scholar]
  69. Collaborative overview of randomised trials of antiplatelet therapy - III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients.BMJ1994308692323524610.1136/bmj.308.6923.235 8054013
     [Google Scholar]
  70. SimesJ. BecattiniC. AgnelliG. Aspirin for the prevention of recurrent venous thromboembolism: the INSPIRE collaboration.Circulation2014130131062107110.1161/CIRCULATIONAHA.114.008828 25156992
     [Google Scholar]
  71. BecattiniC. AgnelliG. SchenoneA. Aspirin for preventing the recurrence of venous thromboembolism.N. Engl. J. Med.2012366211959196710.1056/NEJMoa1114238 22621626
     [Google Scholar]
  72. CavallariI. MorrowD.A. CreagerM.A. Frequency, Predictors, and Impact of Combined Antiplatelet Therapy on Venous Thromboembolism in Patients With Symptomatic Atherosclerosis.Circulation2018137768469210.1161/CIRCULATIONAHA.117.031062 29084737
     [Google Scholar]
  73. EikelboomJ.W. ConnollyS.J. BoschJ. Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease.N. Engl. J. Med.2017377141319133010.1056/NEJMoa1709118 28844192
     [Google Scholar]
  74. AgarwalV. PhungO.J. TongbramV. BhardwajA. ColemanC.I. Statin use and the prevention of venous thromboembolism: a meta-analysis.Int. J. Clin. Pract.201064101375138310.1111/j.1742‑1241.2010.02439.x 20716146
     [Google Scholar]
  75. LiR. YuanM. YuS. Effect of statins on the risk of recurrent venous thromboembolism: A systematic review and meta-analysis.Pharmacol. Res.202116510541310.1016/j.phrs.2020.105413 33412275
     [Google Scholar]
  76. WallaceA. AlbadawiH. HoangP. Statins as a preventative therapy for venous thromboembolism.Cardiovasc. Diagn. Ther.20177S3Suppl. 3S207S21810.21037/cdt.2017.09.12 29399524
     [Google Scholar]
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The Link between Arterial Atherosclerotic Disease and Venous Thromboembolic Disease
Curr. Vasc. Pharmacol. 23, 396 (2025); https://doi.org/10.2174/0115701611345232250212042958
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  • Article Type:     Review Article
Keyword(s): antithrombotic drugs; Arterial atherosclerosis disease; inflammation; pathophysiology; risk factors; venous thromboembolism

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