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2000
Volume 11, Issue 2
  • ISSN: 2215-0838
  • E-ISSN: 2215-0846

Abstract

Nature has always been a wonderful supply of therapeutic substances, providing us with a range of medicinal plants that produce helpful phytochemicals. The native species of the genus Echinacea, which are found in North America and are well-known among medicinal plants, are members of the Asteraceae family. Though there are nine different species of echinacea, only three DC, (L.) Moench, and (Nutt.)-are utilized as medicinal herbs with a variety of therapeutic uses. Contrary to other plant families, the Asteraceae family is one of the most well-known and widely recognized, with many of its members employed for therapeutic purposes. This is largely due to the availability of compounds with a variety of medicinal characteristics. This review has included the investigation of the morphological traits, ethnopharmacology, and diverse pharmacological properties of the Echinacea genus. The chemistry of the genus is extensively understood, and various chemical component groups-including alkamides and caffeic acid derivatives-are believed to be crucial for activity.

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References

  1. LiT.S. WangL.C.H. Physiological components and health effects of ginseng, Echinacea, and sea buckthorn.Functional Foods: Biochemical and Processing Aspects.LancasterTechnomic Publishing1998329356
    [Google Scholar]
  2. McGregorR.L. The taxonomy of the genus Echinacea (Compositae).Univ. Kans. Sci. Bull.196848113142
    [Google Scholar]
  3. ZhangN. EricksonD.L. RamachandranP. OttesenA.R. TimmeR.E. FunkV.A. LuoY. HandyS.M. An analysis of Echinacea chloroplast genomes: Implications for future botanical identification.Sci. Rep.20177121610.1038/s41598‑017‑00321‑628303008
    [Google Scholar]
  4. ShemluckM. Medicinal and other uses of the Compositae by Indians in the United States and Canada.J. Ethnopharmacol.19825330335810.1016/0378‑8741(82)90016‑27045537
    [Google Scholar]
  5. UrbatschL.E. BaldwinB.G. DonoghueM.J. Phylogeny of the coneflowers and relatives (Heliantheae: Asteraceae) based on nuclear rDNA internal transcribed spacer (ITS) sequences and chlorplast DNA restriction site data.Syst. Bot.200025353956510.2307/2666695
    [Google Scholar]
  6. BinnsS.E. BaumB.R. ArnasonJ.T. A taxonomic revision of Echinacea (Asteraceae: Heliantheae).Syst. Bot.2002273610632https://bioone.org/journals/systematic-botany/volume-27/issue-3/0363-6445-27.3.610/A-Taxonomic-Revision-of-span-classgenusspeciesEchinacea-span-Asteraceae/10.1043/0363-6445-27.3.610.short
    [Google Scholar]
  7. HawksK. Coneflowers-An American classic. American Gardner.J. Am. Soc. Hortic. Sci..20048332933
    [Google Scholar]
  8. KimD.H. HeberD. StillD.W. Genetic diversity of Echinacea species based upon amplified fragment length polymorphism markers.Genome200447110211110.1139/g03‑08615060607
    [Google Scholar]
  9. MechandaS.M. BaumB.R. JohnsonD.A. ArnasonJ.T. Sequence assessment of comigrating AFLP TM bands in Echinacea — implications for comparative biological studies.Genome2004471152510.1139/g03‑09415060598
    [Google Scholar]
  10. StarmanT.W. CernyT.A. MacKenzieA.J. Productivity and profitability of some field-grown specialty cut flowers.HortScience19953061217122010.21273/HORTSCI.30.6.1217
    [Google Scholar]
  11. MillerS.C. YuH.C. Echinacea: the genus Echinacea.Crc press200410.1201/9780203022696
    [Google Scholar]
  12. McKeownKA A review of preliminary Echinacea genetics and the future potential of genomics.Echinacea.20042936https://www.taylorfrancis.com/chapters/edit/10.1201/9780203022696-9/review-preliminary-echinacea-genetics-future-potentialgenomics-kathleen-mckeown
    [Google Scholar]
  13. HobbsC. Echinacea: A literature review.HerbalGram199430Suppl.3347
    [Google Scholar]
  14. MillsS. BoneK. Principles and practice of phytotherapy. Modern herbal medicine.Churchill Livingstone2000
    [Google Scholar]
  15. CompendiumB.H. BradelyP.R. British Herbal CompendiumBritish Herbal Medicine AssociationBournemouth1992
    [Google Scholar]
  16. BradleyP.R. British herbal compendium. Volume 1.A handbook of scientific information on widely used plant drugs. Companion to Volume 1 of the British Herbal Pharmacopoeia. In: British Herbal Medicine Association1992
    [Google Scholar]
  17. TylerV.E. The honest herbal.3rd edPhiladelphiaStrickley1993
    [Google Scholar]
  18. Potters Herbal CyclopaediaE.M.W. The autoritative reference work on plants with a known medicinal use.Saffron WaldenThe CW Daniel Company Limited200367
    [Google Scholar]
  19. KindscherK. Ethnobotany of purple coneflower (Echinacea angustifolia, Asteraceae) and OtherEchinacea Species.Econ. Bot.198943449850710.1007/BF02935924
    [Google Scholar]
  20. KindscherK. Medicinal wild plants of the prairie: An ethnobotanical guide.University Press of Kansas1992
    [Google Scholar]
  21. KindscherK. The uses of echinacea angustifolia and other echinacea species by native Americans.Echinacea201692010.1007/978‑3‑319‑18156‑1_2
    [Google Scholar]
  22. FosterS. Echinacea Natures Immune Enhancer.Inner Traditions/Bear and Co.1991
    [Google Scholar]
  23. MengsU. ClareC.B. PoileyJ.A. Toxicity of Echinacea purpurea. Acute, subacute and genotoxicity studies.Arzneimittelforschung19914110107610811799389
    [Google Scholar]
  24. DerMarderosianAH BeutlerJA Facts and Comparisons: The review of natural products: the most complete source of natural product information St. Louis: Facts and Comparisons.2002
    [Google Scholar]
  25. BauerR. LawsonL.D. Phytomedicines of Europe: chemistry and biological activity.Am Chem Soc1998
    [Google Scholar]
  26. SunL. RezaeiK.A. TemelliF. OoraikulB. Supercritical fluid extraction of alkylamides from Echinacea angustifolia. J. Agric. Food Chem.200250143947395310.1021/jf020026512083864
    [Google Scholar]
  27. BauerR. RemigerP. WagnerH. Alkamides from the roots of Echinacea purpurea. Phytochemistry19882772339234210.1016/0031‑9422(88)80156‑017265348
    [Google Scholar]
  28. HohmannJ. RédeiD. ForgoP. SzabóP. FreundT.F. HallerJ. BojnikE. BenyheS. Alkamides and a neolignan from Echinacea purpurea roots and the interaction of alkamides with G-protein-coupled cannabinoid receptors.Phytochemistry20117214-151848185310.1016/j.phytochem.2011.06.00821764086
    [Google Scholar]
  29. BarnesJ. AndersonL.A. GibbonsS. PhillipsonJ.D. Echinacea species ( Echinacea angustifolia (DC.) Hell., Echinacea pallida (Nutt.) Nutt., Echinacea purpurea (L.) Moench): A review of their chemistry, pharmacology and clinical properties.J. Pharm. Pharmacol.201057892995410.1211/002235705612716102249
    [Google Scholar]
  30. QayyumM. GulM. BajwaM.A. PerveenR. AshiqK. GulM. Phytoconstituents and pharmacological profile of Echinacea purpurea. Int. J. Biosci.20211936672
    [Google Scholar]
  31. RöderE. WiedenfeldH. HilleT. Britz-KirstgenR. Pyrrolizidine in Echinacea angustifolia DC und Echinacea purpurea M.Arzneimittelforschung198412423162317
    [Google Scholar]
  32. MazzaG. CottrellT. Volatile components of roots, stems, leaves, and flowers of Echinacea species.J. Agric. Food Chem.19994783081308510.1021/jf981117y10552612
    [Google Scholar]
  33. HudaibM. CavriniV. BellardiM.G. Rubies-AutonellC. Characterization of the essential oils of healthy and virus infected Echinacea purpurea (L.) Moench Plants.J. Essent. Oil Res.200214642743010.1080/10412905.2002.9699911
    [Google Scholar]
  34. VaverkováS. MikulásováM. HabánM. Tekel’J. HolláM. OtepkaP. Variability of the essential oil from three sorts of Echinacea MOENCH genus during ontogenesis.Ceska Slov. Farm.200756312112417867523
    [Google Scholar]
  35. StimpelM. ProkschA. WagnerH. Lohmann-MatthesM.L. Macrophage activation and induction of macrophage cytotoxicity by purified polysaccharide fractions from the plant Echinacea purpurea. Infect. Immun.198446384584910.1128/iai.46.3.845‑849.19846389368
    [Google Scholar]
  36. LuettigB. SteinmüllerC. GiffordG.E. WagnerH. Lohmann-MatthesM.L. Macrophage activation by the polysaccharide arabinogalactan isolated from plant cell cultures of Echinacea purpurea. J. Natl. Cancer Inst.198981966967510.1093/jnci/81.9.6692785214
    [Google Scholar]
  37. TurnerR.B. BauerR. WoelkartK. HulseyT.C. GangemiJ.D. An evaluation of Echinacea angustifolia in experimental rhinovirus infections.N. Engl. J. Med.2005353434134810.1056/NEJMoa04444116049208
    [Google Scholar]
  38. MistrikovaI. VaverkovaS. Echinacea—chemical composition, immunostimulatory activities and uses.Thaiszia J Bot.2006161126
    [Google Scholar]
  39. ChenC.L. ZhangS.C. SungJ.M. Caffeoyl phenols and alkamides of cultivated Echinacea purpurea and Echinacea atrorubens var. paradoxa.Pharm. Biol.200947983584010.1080/13880200902939291
    [Google Scholar]
  40. ChenH. ChenY. LvY. ZengF. ZhangJ. ZhouY. LiH. ChenL. ZhouB. GaoJ. XiaC. Synthesis and antitumor activity of feruloyl and caffeoyl derivatives.Bioorg. Med. Chem. Lett.201424184367437110.1016/j.bmcl.2014.08.02425160837
    [Google Scholar]
  41. HeY.J. LiW.L. LiuB.H. DongH. MouZ.R. WuY.Z. Identification of differential proteins in colorectal cancer cells treated with caffeic acid phenethyl ester.World J. Gastroenterol.20142033118401184910.3748/wjg.v20.i33.1184025206290
    [Google Scholar]
  42. DietzB. BauerR. The constituents of Echinacea atrorubens roots and aerial parts.Pharm. Biol.2001391111510.1076/phbi.39.1.11.5945
    [Google Scholar]
  43. BinnsS.E. LiveseyJ.F. ArnasonJ.T. BaumB.R. Phytochemical variation in echinacea from roots and flowerheads of wild and cultivated populations.J. Agric. Food Chem.200250133673368710.1021/jf011439t12059142
    [Google Scholar]
  44. PellatiF. BenvenutiS. MelegariM. LasseigneT. Variability in the composition of anti-oxidant compounds inEchinacea species by HPLC.Phytochem. Anal.2005162778510.1002/pca.81515881113
    [Google Scholar]
  45. SenchinaD.S. StrauchJ.H. HoffmannG.B. ShahN.B. LaflenB.K. DumkeB.L. DaoC.T. DiasA.S. PereraM.A. Phytochemical and immunomodulatory properties of an Echinacea laevigata (Asteraceae) tincture.J. Altern. Complement. Med.201117437537710.1089/acm.2010.037321473700
    [Google Scholar]
  46. El-SayedA.A. ShalabyA.S. El-HanafyH. El-RazikT.A. Effects of chemical fertilizers on growth and active constituents of Echinacea paradoxa L. plants.J. Hortic. Sci. Ornam. Plants201242125133
    [Google Scholar]
  47. QiangZ HauckC McCoyJA WidrlechnerMP ReddyMB MurphyPA HendrichS Echinacea sanguinea and echinacea pallida extracts stimulate glucuronidation and basolateral transfer of bauer alkamides 8 and 10 and ketone 24 and inhibit p-glycoprotein transporter in caco-2 cells.Planta Medica.20137903/04266274https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0032-1328198
    [Google Scholar]
  48. BauerR. FosterS. Analysis of alkamides and caffeic acid derivatives from Echinacea simulata and E. paradoxa roots.Planta Med.199157544744910.1055/s‑2006‑9601471798799
    [Google Scholar]
  49. BauerR. RemigerP. AlstatE. Alkamides and caffeic acid derivatives from the roots of Echinacea tennesseensis. Planta Med.199056653353410.1055/s‑2006‑961097
    [Google Scholar]
  50. Burlou-NagyC. BănicăF. JurcaT. VicașL.G. MarianE. MuresanM.E. BácskayI. KissR. FehérP. PallagA. Echinacea purpurea (L.) Moench: Biological and Pharmacological Properties. A Review.Plants2022119124410.3390/plants1109124435567246
    [Google Scholar]
  51. Dall’AcquaS. GrabnarI. VerardoR. KlaricE. MarchionniL. Luidy-ImadaE. SutS. AgostinisC. BullaR. PerissuttiB. VoinovichD. Combined extracts of Echinacea angustifolia DC. and Zingiber officinale Roscoe in softgel capsules: Pharmacokinetics and immunomodulatory effects assessed by gene expression profiling.Phytomedicine20196515309010.1016/j.phymed.2019.15309031557666
    [Google Scholar]
  52. Shams EldinS.M. ShawkyE. SallamS.M. El-NikhelyN. El SohafyS.M. Metabolomics approach provides new insights into the immunomodulatory discriminatory biomarkers of the herbs and roots of Echinacea species.Ind. Crops Prod.202116811361110.1016/j.indcrop.2021.113611
    [Google Scholar]
  53. HariaEN PereraMA SenchinaDS Immunomodulatory effects of Echinacea laevigata ethanol tinctures produced from different organs.The Int J Stud Res.20169hzw001https://academic.oup.com/biohorizons/article/doi/10.1093/biohorizons/hzw001/2526813
    [Google Scholar]
  54. El-AshmawyN.E. El-ZamaranyE.A. SalemM.L. El-BahrawyH.A. Al-AshmawyG.M. In vitro and in vivo studies of the immunomodulatory effect of Echinacea purpurea on dendritic cells.J. Genet. Eng. Biotechnol.201513218519210.1016/j.jgeb.2015.05.00230647582
    [Google Scholar]
  55. BillahMM HosenMB KhanF NiazK Nonvitamin and nonmineral nutritional supplements.1st ed. In: Elsevier2019https://www.sciencedirect.com/science/article/abs/pii/B9780128124918000291
    [Google Scholar]
  56. CatanzaroM. CorsiniE. RosiniM. RacchiM. LanniC. Immunomodulators inspired by nature: A review on curcumin and echinacea.Molecules20182311277810.3390/molecules2311277830373170
    [Google Scholar]
  57. DobrangeE. PeshevD. LoedolffB. Van den EndeW. Fructans as immunomodulatory and antiviral agents: The case of Echinacea.Biomolecules201991061510.3390/biom910061531623122
    [Google Scholar]
  58. Nagoor MeeranM.F. JavedH. SharmaC. GoyalS.N. KumarS. JhaN.K. OjhaS. Can Echinacea be a potential candidate to target immunity, inflammation, and infection - The trinity of coronavirus disease 2019.Heliyon202172e0599010.1016/j.heliyon.2021.e0599033585706
    [Google Scholar]
  59. XuW. ZhuH. HuB. ChengY. GuoY. YaoW. QianH. Echinacea in hepatopathy: A review of its phytochemistry, pharmacology, and safety.Phytomedicine20218715357210.1016/j.phymed.2021.15357234029938
    [Google Scholar]
  60. ChengZ.Y. SunX. LiuP. LinB. LiL.Z. YaoG.D. HuangX.X. SongS.J. Sesquiterpenes from Echinacea purpurea and their anti-inflammatory activities.Phytochemistry202017911250310.1016/j.phytochem.2020.11250332919289
    [Google Scholar]
  61. ChoiI.J. ChoiI.J. The antioxidant and anti-inflammatory activities of Echinacea angustifolia hot water extract.Asian J Beauty Cosmetol202220337338110.20402/ajbc.2022.0064
    [Google Scholar]
  62. FanM. WuX. LiX. PiaoX. JiangJ. LianM. Co-cultured adventitious roots of Echinacea pallida and Echinacea purpurea inhibit lipopolysaccharide-induced inflammation via MAPK pathway in mouse peritoneal macrophages.Chin. Herb. Med.202113222823410.1016/j.chmed.2021.01.00136117511
    [Google Scholar]
  63. ElufioyeT.O. HabtemariamS. AdejareA. Chemistry and pharmacology of alkylamides from natural origin.Rev. Bras. Farmacogn.202030562264010.1007/s43450‑020‑00095‑533071385
    [Google Scholar]
  64. RussoD. FaraoneI. LabancaF. SinisgalliC. BartoloM. AndradeP.B. ValentaoP. MilellaL. Comparison of different green‐extraction techniques and determination of the phytochemical profile and antioxidant activity of Echinacea angustifolia L. extracts.Phytochem. Anal.201930554755510.1002/pca.284731148295
    [Google Scholar]
  65. BanicaF. BungauS. TitD.M. BehlT. OtrisalP. NechiforA.C. GiteaD. PavelF.M. NemethS. Determination of the total polyphenols content and antioxidant activity of Echinacea purpurea extracts using newly manufactured glassy carbon electrodes modified with carbon nanotubes.Processes20208783310.3390/pr8070833
    [Google Scholar]
  66. MolaveisiM. Shahidi NoghabiM. ParastoueiK. TaheriR.A. Fate of nano-phytosomes containing bioactive compounds of Echinacea extract in an acidic food beverage.Food Structure20212710017710.1016/j.foostr.2021.100177
    [Google Scholar]
  67. MeiB. XieH. XingH. KongD. PanX. LiY. WuH. Changes of phenolic acids and antioxidant activities in diploid and tetraploid Echinacea purpurea at different growth stages.Rev. Bras. Farmacogn.202030451051810.1007/s43450‑020‑00069‑7
    [Google Scholar]
  68. GecerE.N. ErenlerR. TemizC. GencN. YildizI. Green synthesis of silver nanoparticles from Echinacea purpurea (L.) Moench with antioxidant profile.Particul. Sci. Technol.2022401505710.1080/02726351.2021.1904309
    [Google Scholar]
  69. ArifinP.F. AssaT.I.Y. NoraA. WisastraR. Evaluating the antioxidant activity of echinacea purpurea (L.) Moench ETHANOL EXTRACT.Indones. J. Biotechnol202262394410.47007/ijobb.v6i2.132
    [Google Scholar]
  70. HudsonJ. VimalanathanS. Echinacea—A source of potent antivirals for respiratory virus infections.Pharmaceuticals.2011471019103110.3390/ph4071019
    [Google Scholar]
  71. SenchinaD.S. MartinA.E. BussJ.E. KohutM.L. Effects of Echinacea extracts on macrophage antiviral activities.Phytother. Res.201024681081610.1002/ptr.299120041425
    [Google Scholar]
  72. BharadwajS. El-KafrawyS.A. AlandijanyT.A. BajraiL.H. ShahA.A. DubeyA. SahooA.K. YadavaU. KamalM.A. AzharE.I. KangS.G. DwivediV.D. Structure-Based identification of natural products as SARS-CoV-2 Mpro antagonist from Echinacea angustifolia using computational approaches.Viruses202113230510.3390/v1302030533672054
    [Google Scholar]
  73. VimalanathanS. ShehataM. SadasivamK. DelbueS. DolciM. ParianiE. D’AlessandroS. PleschkaS. Broad antiviral effects of Echinacea purpurea against SARS-CoV-2 variants of concern and potential mechanism of action.Microorganisms20221011214510.3390/microorganisms1011214536363737
    [Google Scholar]
  74. SaifulazmiN.F. RohaniE.R. HarunS. BunawanH. HamezahH.S. Nor MuhammadN.A. AzizanK.A. AhmedQ.U. FakuraziS. MedianiA. SarianM.N. A review with updated perspectives on the antiviral potentials of traditional medicinal plants and their prospects in antiviral therapy.Life.2022128128710.3390/life1208128736013466
    [Google Scholar]
  75. StanisavljevićI. StojičevićS. VeličkovićD. VeljkovićV. LazićM. Antioxidant and antimicrobial activities of Echinacea (Echinacea purpurea L.) extracts obtained by classical and ultrasound extraction.Chin. J. Chem. Eng.200917347848310.1016/S1004‑9541(08)60234‑7
    [Google Scholar]
  76. JamshidiM. BarzegarM. SahariM.A. Effect of gamma and microwave irradiation on antioxidant and antimicrobial activities of Cinnamomum zeylanicum and Echinacea purpurea. Int. Food Res. J.2014214http://www.ifrj.upm.edu.my/21%20(04)%202014/4%20IFRJ%2021%20(04)%202014%20Barzegar%20121.pdf
    [Google Scholar]
  77. OliveiraB.G. SantosL.F. CostaM.C. BastosR.W. CarmoP.H. SantosD.D. PianettiG.A. CésarI.C. Antimicrobial and immunomodulatory activities of dried extracts of Echinacea Purpurea. Braz. J. Pharm. Sci.202358https://www.scielo.br/j/bjps/a/CCRBcPDCJY4nk8JwZxS3zVM/
    [Google Scholar]
  78. Al-HakkaniM.F. GoudaG.A. HassanS.H.A. NagiubA.M. Echinacea purpurea mediated hematite nanoparticles (α-HNPs) biofabrication, characterization, physicochemical properties, and its in-vitro biocompatibility evaluation.Surf. Interfaces20212410111310.1016/j.surfin.2021.101113
    [Google Scholar]
  79. CoelhoJ. BarrosL. DiasM.I. FinimundyT.C. AmaralJ.S. AlvesM.J. CalhelhaR.C. SantosP.F. FerreiraI.C.F.R. Echinacea purpurea (L.) Moench: chemical characterization and bioactivity of its extracts and fractions.Pharmaceuticals202013612510.3390/ph1306012532575791
    [Google Scholar]
  80. Mohamed SharifK.O. TufekciE.F. UstaogluB. AltunogluY.C. ZenginG. Llorent-MartínezE.J. GuneyK. BalogluM.C. Anticancer and biological properties of leaf and flower extracts of Echinacea purpurea (L.) Moench.Food Biosci.20214110100510.1016/j.fbio.2021.101005
    [Google Scholar]
  81. Sharifi-RadM. MnayerD. Morais-BragaM.F.B. CarneiroJ.N.P. BezerraC.F. CoutinhoH.D.M. SalehiB. MartorellM. del Mar ContrerasM. Soltani-NejadA. UribeY.A.H. YousafZ. IritiM. Sharifi-RadJ. Echinacea plants as antioxidant and antibacterial agents: From traditional medicine to biotechnological applications.Phytother. Res.20183291653166310.1002/ptr.610129749084
    [Google Scholar]
  82. ChielliniC. MaidaI. MagginiV. BosiE. MocaliS. EmilianiG. PerrinE. FirenzuoliF. MengoniA. FaniR. Preliminary data on antibacterial activity of Echinacea purpurea -associated bacterial communities against Burkholderia cepacia complex strains, opportunistic pathogens of Cystic Fibrosis patients.Microbiol. Res.2017196344310.1016/j.micres.2016.12.00128164789
    [Google Scholar]
  83. MoghtaderiM. MirzaieA. ZabetN. MoammeriA. Mansoori-KermaniA. AkbarzadehI. Eshrati YeganehF. ChitgarzadehA. Bagheri KashtaliA. RenQ. Enhanced antibacterial activity of Echinacea angustifolia extract against multidrug-resistant Klebsiella pneumoniae through niosome encapsulation.Nanomaterials.2021116157310.3390/nano1106157334203811
    [Google Scholar]
  84. IsmailA. The antifungal properties of a combination of Echinacea purpurea and Echinacea angustifolia mother tinctures on clinically relevant strains of Candida in vitroDoctoral dissertation, University of Johannesburg2022
    [Google Scholar]
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