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image of Qishen Yiqi Dropping Pills Combined with Exosomes Alleviate Myocardial I/R Injury by Regulating Macrophage Polarization via miRNA-155-5P

Abstract

Introduction

To investigate the protective mechanism of Qishen Yiqi Dropping Pills (Qishen) and its key active ingredients in combination with exosomes from bone marrow mesenchymal stem cells (BMSCs) against myocardial ischemia/reperfusion (I/R) injury.

Methods

Infarct area was assessed by Evan's Blue/TTC double staining, myocardial apoptosis was analyzed by TUNEL staining, content and ratio were detected biochemically, macrophage phenotype of myocardial tissues was detected by flow cytometry, activation of the pathway was detected by Western blotting, and expression was detected by qRT-PCR. 155-5p expression. Exo were given to identify the M1/M2 phenotypic transition by immunofluorescence, and the molecular mechanism was verified as in the experiments.

Results

Compared with the model group, the Qishen, ginsenoside, and Exo group significantly reduced the infarcted area of the heart and promoted M2 and M2 phenotypic conversion, promoted M2-type macrophage infiltration, up-regulated the ratio, and inhibited the expression of , but the combination therapy group did not show a synergistic effect, but the above protective effects were significantly weakened by the removal of macrophages. Ginsenoside and Exo synergistically promoted M2 polarization, activated the pathway and upregulated expression.

Discussion

Qishen, particularly its active component ginsenoside, synergizes with BMSC-Exo to alleviate myocardial I/R injury by modulating macrophage polarization the miR-155-5p/mTOR/PI3K/Akt signaling axis.

Conclusion

Qishen synergistically regulates the / signaling axis through ginsenoside components in BMSCs exosomes, promoting macrophage polarization toward M2-type, improving myocardial energy metabolism and attenuating I/R injury, and this protective effect is macrophage-dependent.

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2025-10-27
2026-01-03

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Qishen Yiqi Dropping Pills Combined with Exosomes Alleviate Myocardial I/R Injury by Regulating Macrophage Polarization via miRNA-155-5P
Bentham Science Publishers ; https://doi.org/10.2174/011574888X408846251007045430
/content/journals/cscr/10.2174/011574888X408846251007045430
/content/journals/cscr/10.2174/011574888X408846251007045430
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  • Article Type:     Research Article
Keywords: miRNA-155-5P ; ginsenosides ; Qishen yiqi dropping pills ; exosome-based therapy ; macrophage polarization ; myocardial ischemia-reperfusion injury

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