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image of Research Progress on Pancreatic Islet Organoids

Abstract

Background

Diabetes mellitus (DM) is a condition that arises from the dysfunction or disruption of pancreatic islets, characterized by elevated blood glucose levels. The advent and development of islet organoids have facilitated insulin-independent treatments and the reproduction of complex tissue or organ development.

Objective

This review focuses on the potential and value of islet organoids in both basic research and clinical applications, particularly in addressing the limitations of current diabetes treatments. We further discuss the structural characteristics of islets and explore various methods for obtaining seed cells, constructing organoids, and identifying factors that influence the formation and development of islet organoids.

Methods

The online databases, including Pubmed, Google Scholar, Science Direct, Web of Science, Embase, and reference lists were searched using the keywords diabetes mellitus, islet organoids, beta cells, material, development, three-dimensional, extracellular matrix, biomechanical, to identify published articles relevant to pancreatic islet organoids.

RESULTS

We examine the structural characteristics of islets and investigate various methods for obtaining seed cells, constructing organoids, and identifying factors that influence the formation and maturation of islet organoids.

DISCUSSION

To achieve a cure for diabetes, researchers have made significant efforts in islet transplantation and cell-derived insulin-secreting devices. However, organoids still require substantial improvements in cell sources, assembly techniques, and vascularization.

CONCLUSION

Islet organoids derived from stem cells may enable them to achieve insulin-independent regulation of blood glucose levels, thereby offering new hope for the individuals with diabetes.

© 2025 Bentham Science Publishers
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2025-06-30
2025-09-15

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/content/journals/cscr/10.2174/011574888X383245250617052324
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Research Progress on Pancreatic Islet Organoids
Bentham Science Publishers ; https://doi.org/10.2174/011574888X383245250617052324
/content/journals/cscr/10.2174/011574888X383245250617052324
/content/journals/cscr/10.2174/011574888X383245250617052324
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  • Article Type:     Review Article
Keywords: development ; extracellular matrix ; three-dimensional ; Diabetes mellitus ; islet organoids ; beta cells ; material ; biomechanical

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