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image of PLGA-hucMSC-Ex Ameliorates Colitis by Reversing Epithelial-mesenchymal Transition

Abstract

Introduction

Human umbilical cord mesenchymal stem cell-derived exosomes (hucMSC-Exs) have been found to exhibit therapeutic effects on inflammatory bowel disease (IBD). However, due to the harsh environment of the gastrointestinal tract, exosomes, as a type of biological drug or carrier of bio-active substances, are still delivered by tail vein injection.

Method

In this study, hucMSC-Ex were coated with poly (lactic-co-glycolic acid) (PLGA) polymer to form microparticles, PLGA-hucMSC-Ex, by double emulsion method.

Results

The oral administration of PLGA-hucMSC-Ex particles alleviated inflammation in the mice model of IBD by reversing IBD-induced epithelial-mesenchymal transition (EMT).

Conclusion

This provides an alternative to exploring IBD treatments, with potential clinical application to relieve IBD in patients.

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/content/journals/cscr/10.2174/011574888X344050250320233038
2025-04-09
2025-09-15
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/content/journals/cscr/10.2174/011574888X344050250320233038
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  • Article Type:
    Research Article
Keywords: hucMSC ; IBD ; exosome ; PLGA ; oral administration ; therapy ; EMT
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