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2000
Volume 20, Issue 2
  • ISSN: 1574-888X
  • E-ISSN: 2212-3946

Abstract

Background

Acute Kidney Injury (AKI) is defined as a sudden loss of kidney function, which is often caused by drugs, toxins, and infections. The large spectrum of AKI implies diverse pathophysiological mechanisms. In many cases, AKI can be lethal, and kidney replacement therapy is frequently needed. However, current treatments are not satisfying. Developing novel therapies for AKI is essential. Adult stem cells possess regenerative ability and play an important role in medical research and disease treatment.

Methods

In this study, we isolated and characterized a distinct human urine-derived stem cell, which expressed both proximal tubular cell and mesenchymal stem cell genes as well as certain unique genes.

Results

It was found that these cells exhibited robust protective effects on tubular cells and anti-inflammatory effects on macrophages . In an ischemia-reperfusion-induced acute kidney injury NOD-SCID mouse model, transplantation of USCs significantly protected the kidney morphology and functions .

Conclusion

In summary, our results highlighted the effectiveness of USCs in protecting from PTC injury and impeding macrophage polarization, as well as the secretion of pro-inflammatory interleukins, suggesting the potential of USCs as a novel cell therapy in AKI.

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The Renoprotective and Anti-Inflammatory Effects of Human Urine-Derived Stem Cells on Acute Kidney Injury Animals
Curr Stem Cell Res Ther 20, 199 (2025); https://doi.org/10.2174/011574888X296559240326063705
/content/journals/cscr/10.2174/011574888X296559240326063705
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  • Article Type:     Research Article
Keyword(s): Acute kidney injury; anti-inflammation; cell therapy; mesenchymal stem cell; proximal tubule cell; urine-derived stem cell

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