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2000
Volume 20, Issue 4
  • ISSN: 1574-888X
  • E-ISSN: 2212-3946

Abstract

Background

Aging is a phenomenon which occurs over time and leads to the decay of living organisms. During the progression of aging, some age-associated diseases including cardiovascular disease, cancers, and neurological, mental, and physical disorders could develop. Genetic and epigenetic factors like microRNAs, as one of the post-transcriptional regulators of genes, play important roles in senescence. The self-renewal and differentiation capacity of mesenchymal stem cells makes them good candidates for regenerative medicine.

Objective

The objective of this study is to evaluate senescence-related miRNAs in human MSCs using bioinformatics analysis.

Methods

In this study, the Gene Expression Omnibus (GEO) database was used to investigate the senescence-related genome profile. Then, down-regulated genes were selected for further bioinformatics analysis with the assumption that their decreased expression is associated with an increased aging process. Considering that miRNAs can interfere in gene expression, miRNAs complementary to these genes were identified using bioinformatics software.

Results

Through bioinformatics analysis, we predicted hsa-miR-590-3p, hsa-miR-10b-3p, hsa-miR-548 family, hsa-miR-144-3p, and hsa-miR-30b-5p which involve in cellular senescence and the aging of human MSCs.

Conclusion

miRNA mimics or anti-miRNA agents have the potential to be used as anti-aging tools for MSCs.

© 2025 Bentham Science Publishers
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/content/journals/cscr/10.2174/011574888X291147240507072107
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Prediction of Age-Related MicroRNA Signature in Mesenchymal Stem Cells by using Computational Methods
Curr Stem Cell Res Ther 20, 464 (2025); https://doi.org/10.2174/011574888X291147240507072107
/content/journals/cscr/10.2174/011574888X291147240507072107
/content/journals/cscr/10.2174/011574888X291147240507072107
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  • Article Type:     Research Article
Keyword(s): Aging; bioinformatics software; gene expression omnibus; mesenchymal stem cells; microRNAs; senescence

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