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image of Hyperbaric Oxygen Therapy as a Therapeutic Option for Patients with Fibromyalgia

Abstract

Introduction/Objective

This narrative review has briefly outlined the mechanisms of action underlying the therapeutic effects of hyperbaric oxygen (HBO). It was designed to provide researchers and healthcare professionals with a broad overview of the benefits and potential drawbacks of using HBO in FM patients.

Methods

For this review, we searched PubMed/Medline, Cochrane Library, Embase, and Google Scholar databases for articles published between 2000 and 2023, using the following search terms: “hyperbaric oxygen therapy”, “fibromyalgia”, and “physical exercise”.

Results

In total, more than 90 publications were retrieved, 45 of which were analyzed in depth. The majority of the studies retrieved were of an observational design, whereas there were only a few randomized trials and very few reviews. Based on the compiled literature, there is further support for the hypothesis that reduced oxygen availability may be at the origin of the structural degeneration observed in the muscles of FM patients. In the absence of a universally accepted cure for FM, the therapeutic approach must be multidisciplinary and multimodal. It should be noted that many questions remain unanswered. What is the optimal dose-response range, duration of treatment, and associated economic cost? Larger controlled trials are needed to determine the exact role of HBO as an adjuvant therapy for FM patients.

Conclusion

Based on the published literature, repeated exposure to HBO may be a promising therapeutic adjunct for FM patients. However, more clinical research is needed before HBO can be established as a reliable approach for FM patients.

© 2025 Bentham Science Publishers
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2025-07-07
2025-10-25

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References

  1. Talotta R. Atzeni F. Bazzichi L. Giacomelli C. Di Franco M. Salaffi F. Sarzi-Puttini P. Algo-dysfunctional syndromes: A critical digest of the recent literature. Clin. Exp. Rheumatol. 2015 33 1 S102 S108 25786051
    [Google Scholar]
  2. Martínez-Martínez L.A. Mora T. Vargas A. Fuentes-Iniestra M. Martínez-Lavín M. Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: A review of case-control studies. J. Clin. Rheumatol. 2014 20 3 146 150 10.1097/RHU.0000000000000089 24662556
    [Google Scholar]
  3. Sumpton J.E. Moulin D.E. Fibromyalgia. Handb. Clin. Neurol. 2014 119 513 527 10.1016/B978‑0‑7020‑4086‑3.00033‑3 24365316
    [Google Scholar]
  4. Heidari F. Afshari M. Moosazadeh M. Prevalence of fibromyalgia in general population and patients, a systematic review and meta-analysis. Rheumatol. Int. 2017 37 9 1527 1539 10.1007/s00296‑017‑3725‑2 28447207
    [Google Scholar]
  5. Bannwarth B. Blotman F. Roué-Le Lay K. Caubère J.P. André E. Taïeb C. Fibromyalgia syndrome in the general population of France: A prevalence study. Joint Bone Spine 2009 76 2 184 187 10.1016/j.jbspin.2008.06.002 18819831
    [Google Scholar]
  6. Perrot S. Vicaut E. Servant D. Ravaud P. Prevalence of fibromyalgia in France: A multi-step study research combining national screening and clinical confirmation: The DEFI study (Determination of Epidemiology of FIbromyalgia). BMC Musculoskelet. Disord. 2011 12 1 224 10.1186/1471‑2474‑12‑224 21981821
    [Google Scholar]
  7. Branco J.C. Bannwarth B. Failde I. Abello Carbonell J. Blotman F. Spaeth M. Saraiva F. Nacci F. Thomas E. Caubère J.P. Le Lay K. Taieb C. Matucci-Cerinic M. Prevalence of fibromyalgia: A survey in five European countries. Semin. Arthritis Rheum. 2010 39 6 448 453 10.1016/j.semarthrit.2008.12.003 19250656
    [Google Scholar]
  8. Mease P.J. Clauw D.J. Arnold L.M. Goldenberg D.L. Witter J. Williams D.A. Simon L.S. Strand C.V. Bramson C. Martin S. Wright T.M. Littman B. Wernicke J.F. Gendreau R.M. Crofford L.J. Fibromyalgia syndrome. J. Rheumatol. 2005 32 11 2270 2277 16265715
    [Google Scholar]
  9. Wolfe F. Smythe H.A. Yunus M.B. Bennett R.M. Bombardier C. Goldenberg D.L. Tugwell P. Campbell S.M. Abeles M. Clark P. Fam A.G. Farber S.J. Fiechtner J.J. Michael Franklin C. Gatter R.A. Hamaty D. Lessard J. Lichtbroun A.S. Masi A.T. Mccain G.A. John Reynolds W. Romano T.J. Jon Russell I. Sheon R.P. The American college of rheumatology 1990 criteria for the classification of fibromyalgia. Arthritis Rheum. 1990 33 2 160 172 10.1002/art.1780330203 2306288
    [Google Scholar]
  10. Wolfe F. Clauw D.J. Fitzcharles M.A. Goldenberg D.L. Häuser W. Katz R.L. Mease P.J. Russell A.S. Russell I.J. Walitt B. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin. Arthritis Rheum. 2016 46 3 319 329 10.1016/j.semarthrit.2016.08.012 27916278
    [Google Scholar]
  11. Martinez J.E. Guimarães I. “Fibromyalgia – are there any new approaches?”. Best Pract. Res. Clin. Rheumatol. 2024 38 1 101933 10.1016/j.berh.2024.101933 38355316
    [Google Scholar]
  12. Di Sabato F. Fusco B.M. Pelaia P. Giacovazzo M. Hyperbaric oxygen therapy in cluster headache. Pain 1993 52 2 243 245 10.1016/0304‑3959(93)90137‑E 8455970
    [Google Scholar]
  13. Bennett M.H. French C. Schnabel A. Wasiak J. Kranke P. Normobaric and hyperbaric oxygen therapy for migraine and cluster headache. Cochrane Database Syst. Rev. 2008 3 CD005219 18646121
    [Google Scholar]
  14. Yildiz Ş. Kiralp M.Z. Akin A. Keskin I. Ay H. Dursun H. Cimsit M. A new treatment modality for fibromyalgia syndrome: Hyperbaric oxygen therapy. J. Int. Med. Res. 2004 32 3 263 267 10.1177/147323000403200305 15174219
    [Google Scholar]
  15. Fassbender H.G. Wegner K. Morphologie und pathogenese des weichteilrheumatismus. Z. Rheumaforsch. 1973 32 9 355 374 4544013
    [Google Scholar]
  16. Wen B. Zhang G. Zhan C. Chen C. Yi H. The 2024 revision of the Declaration of Helsinki: A modern ethical framework for medical research. Postgrad. Med. J. 2025 101 1194 371 382 10.1093/postmj/qgae181
    [Google Scholar]
  17. James P.B. Indications for oxygen therapy and the Undersea and Hyperbaric Medical Society. Med. Gas Res. 2023 13 4 219 10.4103/2045‑9912.372064 37077122
    [Google Scholar]
  18. Kranke P. Bennett M. Roeckl-Wiedmann I. Debus S. Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst. Rev. 2004 2 CD004123 15106239
    [Google Scholar]
  19. Fu Q. Duan R. Sun Y. Li Q. Hyperbaric oxygen therapy for healthy aging: From mechanisms to therapeutics. Redox Biol. 2022 53 102352 10.1016/j.redox.2022.102352 35649312
    [Google Scholar]
  20. Wang D. Liu M. Jia S. Tian Z. Yang J. Liu X. Hyperbaric oxygen therapy for cardiovascular surgery. Med. Gas Res. 2025 15 2 299 308 10.4103/mgr.MEDGASRES‑D‑24‑00095 39829165
    [Google Scholar]
  21. Mielecki D. Godlewski J. Salinska E. Hyperbaric oxygen therapy for the treatment of hypoxic/ischemic injury upon perinatal asphyxia—are we there yet? Front. Neurol. 2024 15 1386695 10.3389/fneur.2024.1386695 38685945
    [Google Scholar]
  22. Atzeni F. Masala I.F. Cirillo M. Boccassini L. Sorbara S. Alciati A. Hyperbaric oxygen therapy in fibromyalgia and the diseases involving the central nervous system. Clin. Exp. Rheumatol. 2020 38 1 94 98 32116209
    [Google Scholar]
  23. Brentnall M. Rodriguez-Menocal L. De Guevara R.L. Cepero E. Boise L.H. Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis. BMC Cell Biol. 2013 14 1 32 10.1186/1471‑2121‑14‑32 23834359
    [Google Scholar]
  24. Rus A. Robles-Fernandez I. Martinez-Gonzalez L.J. Carmona R. Alvarez-Cubero M.J. Influence of oxidative stress-related genes on susceptibility to fibromyalgia. Nurs. Res. 2021 70 1 44 50 10.1097/NNR.0000000000000480 32991532
    [Google Scholar]
  25. Palzur E. Zaaroor M. Vlodavsky E. Milman F. Soustiel J.F. Neuroprotective effect of hyperbaric oxygen therapy in brain injury is mediated by preservation of mitochondrial membrane properties. Brain Res. 2008 1221 126 133 10.1016/j.brainres.2008.04.078 18561900
    [Google Scholar]
  26. Assavarittirong C. Samborski W. Grygiel-Górniak B. Oxidative stress in fibromyalgia: From pathology to treatment. Oxid. Med. Cell. Longev. 2022 2022 1 11 10.1155/2022/1582432 36246401
    [Google Scholar]
  27. Larson A.A. Giovengo S.L. Russell J.I. Michalek J.E. Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: Implications for nitric oxide pathways. Pain 2000 87 2 201 211 10.1016/S0304‑3959(00)00284‑0 10924813
    [Google Scholar]
  28. Urban M.O. Gebhart G.F. Central mechanisms in pain. Med. Clin. North Am. 1999 83 3 585 596 10.1016/S0025‑7125(05)70125‑5 10386116
    [Google Scholar]
  29. Nesovic Ostojic J. Ivanov M. Mihailovic-Stanojevic N. Karanovic D. Kovacevic S. Brkic P. Zivotic M. Vajic U.J. Jovovic D. Jeremic R. Ljubojevic-Holzer S. Miloradovic Z. Hyperbaric oxygen preconditioning upregulates heme oxygenase-1 and anti-apoptotic bcl-2 protein expression in spontaneously hypertensive rats with induced postischemic acute kidney injury. Int. J. Mol. Sci. 2021 22 3 1382 10.3390/ijms22031382 33573145
    [Google Scholar]
  30. Guggino G. Schinocca C. Lo Pizzo M. Di Liberto D. Garbo D. Raimondo S. Alessandro R. Brighina F. Ruscitti P. Giacomelli R. Sireci G. Triolo G. Casale R. Sarzi-Puttini P. Dieli F. T helper 1 response is correlated with widespread pain, fatigue, sleeping disorders and the quality of life in patients with fibromyalgia and is modulated by hyperbaric oxygen therapy. Clin. Exp. Rheumatol. 2019 37 1 81 89 30747094
    [Google Scholar]
  31. Hedetoft M. Garred P. Madsen M.B. Hyldegaard O. Hyperbaric oxygen treatment is associated with a decrease in cytokine levels in patients with necrotizing soft-tissue infection. Physiol. Rep. 2021 9 6 14757 10.14814/phy2.14757 33719215
    [Google Scholar]
  32. Lund N. Bengtsson A. Thorborg P. Muscle tissue oxygen pressure in primary fibromyalgia. Scand. J. Rheumatol. 1986 15 2 165 173 10.3109/03009748609102084 3462905
    [Google Scholar]
  33. Efrati S. Golan H. Bechor Y. Faran Y. Daphna-Tekoah S. Sekler G. Fishlev G. Ablin J.N. Bergan J. Volkov O. Friedman M. Ben-Jacob E. Buskila D. Hyperbaric oxygen therapy can diminish fibromyalgia syndrome-prospective clinical trial. PLoS One 2015 10 5 0127012 10.1371/journal.pone.0127012 26010952
    [Google Scholar]
  34. Schnurr P.P. Green B.L. Understanding relationships among trauma, post-tramatic stress disorder, and health outcomes. Adv. Mind Body Med. 2004 20 1 18 29 15068106
    [Google Scholar]
  35. Hadanny A. Bechor Y. Catalogna M. Daphna-Tekoah S. Sigal T. Cohenpour M. Lev-Wiesel R. Efrati S. Hyperbaric oxygen therapy can induce neuroplasticity and significant clinical improvement in patients suffering from fibromyalgia with a history of childhood sexual abuse—randomized controlled trial. Front. Psychol. 2018 9 2495 10.3389/fpsyg.2018.02495 30618929
    [Google Scholar]
  36. El-Shewy K.M. Kunbaz A. Gad M.M. Al-Husseini M.J. Saad A.M. Sammour Y.M. Abdel-Daim M.M. Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review. Biomed. Pharmacother. 2019 109 629 638 10.1016/j.biopha.2018.10.157 30399600
    [Google Scholar]
  37. Thomas E.N. Blotman F. Aerobic exercise in fibromyalgia: A practical review. Rheumatol. Int. 2010 30 9 1143 1150 10.1007/s00296‑010‑1369‑6 20340025
    [Google Scholar]
  38. Bosco G. Ostardo E. Rizzato A. Garetto G. Paganini M. Melloni G. Giron G. Pietrosanti L. Martinelli I. Camporesi E. Clinical and morphological effects of hyperbaric oxygen therapy in patients with interstitial cystitis associated with fibromyalgia. BMC Urol. 2019 19 1 108 10.1186/s12894‑019‑0545‑6 31690286
    [Google Scholar]
  39. van Ophoven A. Rossbach G. Oberpenning F. Hertle L. Hyperbaric oxygen for the treatment of interstitial cystitis: Long-term results of a prospective pilot study. Eur. Urol. 2004 46 1 108 113 10.1016/j.eururo.2004.03.002 15183555
    [Google Scholar]
  40. Nickel J.C. Tripp D.A. Pontari M. Moldwin R. Mayer R. Carr L.K. Doggweiler R. Yang C.C. Mishra N. Nordling J. Interstitial cystitis/painful bladder syndrome and associated medical conditions with an emphasis on irritable bowel syndrome, fibromyalgia and chronic fatigue syndrome. J. Urol. 2010 184 4 1358 1363 10.1016/j.juro.2010.06.005 20719340
    [Google Scholar]
  41. Atzeni F. Casale R. Alciati A. Masala I.F. Batticciotto A. Talotta R. Gerardi M.C. Salaffi F. Sarzi-Puttini P. Hyperbaric oxygen treatment of fibromyalgia: A prospective observational clinical study. Clin. Exp. Rheumatol. 2019 37 1 63 69 30747099
    [Google Scholar]
  42. Casale R. Boccia G. Symeonidou Z. Atzeni F. Batticciotto A. Salaffi F. Sarzi-Puttini P. Brustio P.R. Rainoldi A. Neuromuscular efficiency in fibromyalgia is improved by hyperbaric oxygen therapy: Looking inside muscles by means of surface electromyography. Clin. Exp. Rheumatol. 2019 37 1 75 80 30747100
    [Google Scholar]
  43. Izquierdo-Alventosa R. Inglés M. Cortés-Amador S. Gimeno-Mallench L. Chirivella-Garrido J. Kropotov J. Serra-Añó P. Low-intensity physical exercise improves pain catastrophizing and other psychological and physical aspects in women with fibromyalgia: A randomized controlled trial. Int. J. Environ. Res. Public Health 2020 17 10 3634 10.3390/ijerph17103634 32455853
    [Google Scholar]
  44. Winfield-Vargas J.G. Ramírez-Nava J. Rodríguez-Ayala V. Cruz-Sánchez J. Solís-Chagoyán H. Aquino-Gálvez A. Romero-Martínez B. Montaño L. Flores-soto E. Hyperbaric oxygen therapy ameliorates pain in overweight or obese patients diagnosed with fibromyalgia. World Acad. Sci. J. 2021 3 4 36 10.3892/wasj.2021.107
    [Google Scholar]
  45. Álvarez-Nemegyei J. Pacheco-Pantoja E.L. Olán-Centeno L.J. Angulo-Ramírez A. Rodríguez-Magaña F.E. Aranda-Muiña J.F. Association between fibromyalgia syndrome clinical severity and body composition. A principal component analysis. Reumatología Clínica 2022 18 9 538 545 10.1016/j.reumae.2021.09.008 36309410
    [Google Scholar]
  46. Karczewski J. Śledzińska E. Baturo A. Jończyk I. Maleszko A. Maleszko A. Samborski P. Begier-Krasińska B. Dobrowolska A. Obesity and inflammation. Eur. Cytokine Netw. 2018 29 3 83 94 10.1684/ecn.2018.0415 30547890
    [Google Scholar]
  47. Jeyaraman M. Sami A. Nallakumarasamy A. Jeyaraman N. Jain V.K. Hyperbaric oxygen therapy in orthopaedics: An adjunct therapy with an emerging role. Indian J. Orthop. 2023 57 5 748 761 10.1007/s43465‑023‑00837‑2 37128570
    [Google Scholar]
  48. Paroli M. Gioia C. Accapezzato D. Caccavale R. Inflammation, autoimmunity, and infection in fibromyalgia: A narrative review. Int. J. Mol. Sci. 2024 25 11 5922 10.3390/ijms25115922 38892110
    [Google Scholar]
  49. Alciati A. Cirillo M. Masala I.F. Sarzi-Puttini P. Atzeni F. Differences in depression, anxiety and stress disorders between fibromyalgia associated with rheumatoid arthritis and primary fibromyalgia. Stress Health 2021 37 2 255 262 10.1002/smi.2992 32991777
    [Google Scholar]
  50. Duffield S.J. Miller N. Zhao S. Goodson N.J. Concomitant fibromyalgia complicating chronic inflammatory arthritis: A systematic review and meta-analysis. Rheumatology 2018 57 8 1453 1460 10.1093/rheumatology/key112 29788461
    [Google Scholar]
  51. Macfarlane G.J. Barnish M.S. Pathan E. Martin K.R. Haywood K.L. Siebert S. Packham J. Atzeni F. Jones G.T. Co-occurrence and characteristics of patients with axial spondyloarthritis who meet criteria for fibromyalgia. Arthritis Rheumatol. 2017 69 11 2144 2150 10.1002/art.40185 28622461
    [Google Scholar]
  52. Bello N. Etcheto A. Béal C. Dougados M. Moltó A. Evaluation of the impact of fibromyalgia in disease activity and treatment effect in spondyloarthritis. Arthritis Res. Ther. 2016 18 1 42 10.1186/s13075‑016‑0943‑z 26860612
    [Google Scholar]
  53. Wach J. Letroublon M.C. Coury F. Tebib J.G. Fibromyalgia in spondyloarthritis: Effect on disease activity assessment in clinical practice. J. Rheumatol. 2016 43 11 2056 2063 10.3899/jrheum.160104 27633820
    [Google Scholar]
  54. Jones E.A. Asaad F. Patel N. Jain E. Abd-Elsayed A. Management of fibromyalgia: An update. Biomedicines 2024 12 6 1266 10.3390/biomedicines12061266 38927473
    [Google Scholar]
  55. García-Ríos M.C. Navarro-Ledesma S. Tapia-Haro R.M. Toledano-Moreno S. Casas-Barragán A. Correa-Rodríguez M. Aguilar-Ferrándiz M.E. Effectiveness of health education in patients with fibromyalgia: A systematic review. Eur. J. Phys. Rehabil. Med. 2019 55 2 301 313 10.23736/S1973‑9087.19.05524‑2 30698402
    [Google Scholar]
  56. Farag H.M. Yunusa I. Goswami H. Sultan I. Doucette J.A. Eguale T. Comparison of amitriptyline and US food and drug administration–approved treatments for fibromyalgia. JAMA Netw. Open 2022 5 5 2212939 10.1001/jamanetworkopen.2022.12939 35587348
    [Google Scholar]
  57. Branco J.C. Zachrisson O. Perrot S. Mainguy Y. A European multicenter randomized double-blind placebo-controlled monotherapy clinical trial of milnacipran in treatment of fibromyalgia. J. Rheumatol. 2010 37 4 851 859 10.3899/jrheum.090884 20156949
    [Google Scholar]
  58. Alorfi N.M. Pharmacological treatments of fibromyalgia in adults; overview of phase IV clinical trials. Front. Pharmacol. 2022 13 1017129 10.3389/fphar.2022.1017129 36210856
    [Google Scholar]
  59. Derry S. Wiffen P.J. Häuser W. Mücke M. Tölle T.R. Bell R.F. Moore R.A. Oral nonsteroidal anti-inflammatory drugs for fibromyalgia in adults. Cochrane Libr. 2017 2020 2 CD012332 10.1002/14651858.CD012332.pub2 28349517
    [Google Scholar]
  60. Abd-Elsayed A. Gilligan C. Cannabis for treating fibromyalgia. Pain Pract. 2023 23 5 566 567 10.1111/papr.13211 36751980
    [Google Scholar]
  61. Pastrak M. Abd-Elsayed A. Ma F. Vrooman B. Visnjevac O. Systematic review of the use of intravenous ketamine for fibromyalgia. Ochsner J. 2021 21 4 387 394 10.31486/toj.21.0038 34984054
    [Google Scholar]
  62. Hudson J.I. Pope H.G. Jr Does childhood sexual abuse cause fibromyalgia? Arthritis Rheum. 1995 38 2 161 163 10.1002/art.1780380203 7848305
    [Google Scholar]
  63. Golstein M.A. Steinfeld S.D. Non-genetic familial transmission of fibromyalgia: Role of sexual abuse? Clin. Exp. Rheumatol. 2022 40 6 1221 1222 35238749
    [Google Scholar]
  64. Häuser W. Hoffmann E.M. Wolfe F. Worthing A.B. Stahl N. Rothenberg R. Walitt B. Self-reported childhood maltreatment, lifelong traumatic events and mental disorders in fibromyalgia syndrome: A comparison of US and German outpatients. Clin. Exp. Rheumatol. 2015 33 1 S86 S92 25786049
    [Google Scholar]
  65. Boussi-Gross R. Catalogna M. Lang E. Shamai Z. Ablin J.N. Aloush V. Doenyas-Barak K. Lorberboym M. Lev-Wiesel R. Efrati S. Hyperbaric oxygen therapy vs. pharmacological intervention in adults with fibromyalgia related to childhood sexual abuse: Prospective, randomized clinical trial. Sci. Rep. 2024 14 1 11599 10.1038/s41598‑024‑62161‑5 38773296
    [Google Scholar]
  66. Wu B.Q. Liu D.Y. Shen T.C. Lai Y.R. Yu T.L. Hsu H.L. Lee H.M. Liao W.C. Hsia T.C. Effects of hyperbaric oxygen therapy on long covid: A systematic review. Life 2024 14 4 438 10.3390/life14040438 38672710
    [Google Scholar]
  67. Mariette X. Long COVID: A new word for naming fibromyalgia? Ann. Rheum. Dis. 2024 83 1 12 14 10.1136/ard‑2023‑224848 37923365
    [Google Scholar]
  68. Zant A.E. Figueroa X.A. Paulson C.P. Wright J.K. Hyperbaric oxygen therapy to treat lingering COVID-19 symptoms. Undersea Hyperb. Med. 2022 49 3 333 339 10.22462/05.06.2022.7 36001566
    [Google Scholar]
  69. Lindenmann J. Porubsky C. Okresa L. Klemen H. Mykoliuk I. Roj A. Koutp A. Kink E. Iberer F. Kovacs G. Krause R. Smolle J. Smolle-Juettner F.M. Immediate and long-term effects of hyperbaric oxygenation in patients with long covid-19 syndrome using sf-36 survey and vas score: A clinical pilot study. J. Clin. Med. 2023 12 19 6253 10.3390/jcm12196253 37834897
    [Google Scholar]
  70. Mrakic-Sposta S. Vezzoli A. Garetto G. Paganini M. Camporesi E. Giacon T.A. Dellanoce C. Agrimi J. Bosco G. Hyperbaric oxygen therapy counters oxidative stress/inflammation-driven symptoms in long covid-19 patients: Preliminary outcomes. Metabolites 2023 13 10 1032 10.3390/metabo13101032 37887357
    [Google Scholar]
  71. Kjellberg A. Hassler A. Boström E. El Gharbi S. Al-Ezerjawi S. Kowalski J. Rodriguez-Wallberg K.A. Bruchfeld J. Ståhlberg M. Nygren-Bonnier M. Runold M. Lindholm P. Hyperbaric oxygen therapy for long COVID (HOT-LoCO), an interim safety report from a randomised controlled trial. BMC Infect. Dis. 2023 23 1 33 10.1186/s12879‑023‑08002‑8 36670365
    [Google Scholar]
  72. Bhaiyat A.M. Sasson E. Wang Z. Khairy S. Ginzarly M. Qureshi U. Fikree M. Efrati S. Hyperbaric oxygen treatment for long coronavirus disease-19: A case report. J. Med. Case Reports 2022 16 1 80 10.1186/s13256‑022‑03287‑w 35168680
    [Google Scholar]
  73. Robbins T. Gonevski M. Clark C. Baitule S. Sharma K. Magar A. Patel K. Sankar S. Kyrou I. Ali A. Randeva H.S. Hyperbaric oxygen therapy for the treatment of long COVID: Early evaluation of a highly promising intervention. Clin. Med. 2021 21 6 e629 e632 10.7861/clinmed.2021‑0462 34862223
    [Google Scholar]
  74. Pawlik M.T. Rinneberg G. Koch A. Meyringer H. Loew T.H. Kjellberg A. Is there a rationale for hyperbaric oxygen therapy in the patients with Post COVID syndrome? Eur. Arch. Psychiatry Clin. Neurosci. 2024 274 8 1797 1817 10.1007/s00406‑024‑01911‑y 39545965
    [Google Scholar]
  75. Zilberman-Itskovich S. Catalogna M. Sasson E. Elman-Shina K. Hadanny A. Lang E. Finci S. Polak N. Fishlev G. Korin C. Shorer R. Parag Y. Sova M. Efrati S. Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: Randomized controlled trial. Sci. Rep. 2022 12 1 11252 10.1038/s41598‑022‑15565‑0 35821512
    [Google Scholar]
  76. Tieland M. Trouwborst I. Clark B.C. Skeletal muscle performance and ageing. J. Cachexia Sarcopenia Muscle 2018 9 1 3 19 10.1002/jcsm.12238 29151281
    [Google Scholar]
  77. Hadanny A. Sasson E. Copel L. Daniel-Kotovsky M. Yaakobi E. Lang E. Fishlev G. Polak N. Friedman M. Doenyas K. Finci S. Zemel Y. Bechor Y. Efrati S. Physical enhancement of older adults using hyperbaric oxygen: A randomized controlled trial. BMC Geriatr. 2024 24 1 572 10.1186/s12877‑024‑05146‑3 38961397
    [Google Scholar]
  78. Scheef L. Jankowski J. Daamen M. Weyer G. Klingenberg M. Renner J. Mueckter S. Schürmann B. Musshoff F. Wagner M. Schild H.H. Zimmer A. Boecker H. An fMRI study on the acute effects of exercise on pain processing in trained athletes. Pain 2012 153 8 1702 1714 10.1016/j.pain.2012.05.008 22704853
    [Google Scholar]
  79. Lopresti A.L. Hood S.D. Drummond P.D. A review of lifestyle factors that contribute to important pathways associated with major depression: Diet, sleep and exercise. J. Affect. Disord. 2013 148 1 12 27 10.1016/j.jad.2013.01.014 23415826
    [Google Scholar]
  80. Tang N.K.Y. Sanborn A.N. Tang N.K. Better quality sleep promotes daytime physical activity in patients with chronic pain? A multilevel analysis of the within-person relationship. PLoS One 2014 9 3 92158 10.1371/journal.pone.0092158 24667276
    [Google Scholar]
  81. Alcántara Montero A. Sánchez Carnerero C.I. Recomendaciones revisadas de la EULAR para el manejo de la fibromialgia. Semergen 2017 43 6 472 473 10.1016/j.semerg.2016.07.016 27773626
    [Google Scholar]
  82. Bidonde J. Busch A.J. Schachter C.L. Overend T.J. Kim S.Y. Góes S.M. Boden C. Foulds H.J.A. Aerobic exercise training for adults with fibromyalgia. Cochrane Libr. 2017 2017 6 CD012700 10.1002/14651858.CD012700 28636204
    [Google Scholar]
  83. Busch A.J. Schachter C.L. Overend T.J. Peloso P.M. Barber K.A. Exercise for fibromyalgia: A systematic review. J. Rheumatol. 2008 35 6 1130 1144 18464301
    [Google Scholar]
  84. Bower J.E. Greendale G. Crosswell A.D. Garet D. Sternlieb B. Ganz P.A. Irwin M.R. Olmstead R. Arevalo J. Cole S.W. Yoga reduces inflammatory signaling in fatigued breast cancer survivors: A randomized controlled trial. Psychoneuroendocrinology 2014 43 20 29 10.1016/j.psyneuen.2014.01.019 24703167
    [Google Scholar]
  85. Irwin M.R. Olmstead R. Breen E.C. Witarama T. Carrillo C. Sadeghi N. Arevalo J.M.G. Ma J. Nicassio P. Bootzin R. Cole S. Cognitive behavioral therapy and tai chi reverse cellular and genomic markers of inflammation in late-life insomnia: A randomized controlled trial. Biol. Psychiatry 2015 78 10 721 729 10.1016/j.biopsych.2015.01.010 25748580
    [Google Scholar]
  86. Metyas C. Aung T.T. Cheung J. Joseph M. Ballester A.M. Metyas S. Diet and lifestyle modifications for fibromyalgia. Curr. Rheumatol. Rev. 2024 20 4 405 413 10.2174/0115733971274700231226075717 38279728
    [Google Scholar]
  87. Wood P.B. Ledbetter C.R. Glabus M.F. Broadwell L.K. Patterson J.C. II Hippocampal metabolite abnormalities in fibromyalgia: Correlation with clinical features. J. Pain 2009 10 1 47 52 10.1016/j.jpain.2008.07.003 18771960
    [Google Scholar]
  88. McCrae C. O’Shea A. Boissoneault J. Vatthauer K. Robinson M. Staud R. Perlstein W. Craggs J. Fibromyalgia patients have reduced hippocampal volume compared with healthy controls. J. Pain Res. 2015 8 47 52 10.2147/JPR.S71959 25674013
    [Google Scholar]
  89. Martinez-Lavin M. Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia. Arthritis Res. Ther. 2007 9 4 216 10.1186/ar2146 17626613
    [Google Scholar]
  90. O’Connor P.J. Youngstedt S.D. Influence of exercise on human sleep. Exerc. Sport Sci. Rev. 1995 23 105 134 7556348
    [Google Scholar]
  91. Bennett R. Nelson D. Cognitive behavioral therapy for fibromyalgia. Nat. Clin. Pract. Rheumatol. 2006 2 8 416 424 10.1038/ncprheum0245 16932733
    [Google Scholar]
  92. Senna M.K. Sallam R.A.E.R. Ashour H.S. Elarman M. Effect of weight reduction on the quality of life in obese patients with fibromyalgia syndrome: A randomized controlled trial. Clin. Rheumatol. 2012 31 11 1591 1597 10.1007/s10067‑012‑2053‑x 22948223
    [Google Scholar]
  93. Ataoglu S. Ankarali H. Samanci R. Ozsahin M. Admis O. The relationship between serum leptin level and disease activity and inflammatory markers in fibromyalgia patients. North. Clin. Istanb. 2018 5 2 102 108 30374474
    [Google Scholar]
  94. Younger J. Kapphahn K. Brennan K. Sullivan S.D. Stefanick M.L. Association of Leptin with Body Pain in Women. J. Womens Health 2016 25 7 752 760 10.1089/jwh.2015.5509 27028709
    [Google Scholar]
  95. Andrade A. Vilarino G.T. Sieczkowska S.M. Coimbra D.R. Bevilacqua G.G. Steffens R.A.K. The relationship between sleep quality and fibromyalgia symptoms. J. Health Psychol. 2020 25 9 1176 1186 10.1177/1359105317751615 29310453
    [Google Scholar]
  96. Zhang Y. Zhou Y. Jia Y. Wang T. Meng D. Adverse effects of hyperbaric oxygen therapy: A systematic review and meta-analysis. Front. Med. 2023 10 1160774 10.3389/fmed.2023.1160774 37275378
    [Google Scholar]
  97. Clauw D.J. Fibromyalgia. JAMA 2014 311 15 1547 1555 10.1001/jama.2014.3266 24737367
    [Google Scholar]
  98. Giorgi V. Bazzichi L. Batticciotto A. Pellegrino G. Di Franco M. Sirotti S. Atzeni F. Alciati A. Salaffi F. Sarzi Puttini P. Fibromyalgia: One year in review 2023. Clin. Exp. Rheumatol. 2023 41 6 1205 1213 37378487
    [Google Scholar]
  99. Hackshaw K.V. The search for biomarkers in fibromyalgia. Diagnostics 2021 11 2 156 10.3390/diagnostics11020156 33494476
    [Google Scholar]
/content/journals/crr/10.2174/0115733971370773250625104646
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Hyperbaric Oxygen Therapy as a Therapeutic Option for Patients with Fibromyalgia
Bentham Science Publishers ; https://doi.org/10.2174/0115733971370773250625104646
/content/journals/crr/10.2174/0115733971370773250625104646
/content/journals/crr/10.2174/0115733971370773250625104646
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  • Article Type:     Review Article
Keywords: fibromyalgia ; chronic pain conditions ; Hyperbaric oxygen therapy ; aerobic ; neuroplasticity ; hyperbaric oxygen (HBO)

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