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2000
Volume 21, Issue 3
  • ISSN: 1573-3971
  • E-ISSN: 1875-6360

Abstract

Background

Modern sedentary lifestyles are prevalent among individuals with osteoarthritis. However, direct evidence linking such behaviours as causative factors of osteoarthritis remain limited due to the presence of confounding variables.

Objective

This study aims to determine the extent to which lifestyle factors have causal effects on osteoarthritis through a two-sample Mendelian randomisation (MR) study.

Methods

Exposure-outcome relationships were evaluated using inverse variance weighted two-sample MR and summary statistics of genome-wide association studies of lifestyle factors and osteoarthritis. Weighted median, MR-PRESSO, and MR-Egger regression were used as sensitivity analyses. We obtained causality estimates, 95% confidence intervals (CI), and -values from each MR method. Steiger filtering and radial filtering were used to exclude SNPs demonstrating reverse causality and significant heterogeneity, respectively.

Results

MR analyses demonstrated that certain lifestyle factors had causal effects on osteoarthritis, particularly insomnia (OR 1.09 (0.387-1.79), = 0.0024), BMI (OR 6.45 (4.48-8.42), = 1.38e-10) and protein intake (OR 2.94 (0.361-5.52), = 0.026). Effects were consistent across sensitivity analyses using median-based MR methods. & , and potentially & are genetic loci identified to mediate these causal effects.

Conclusion

Our results illustrate that lifetime exposure to certain lifestyle factors has causal effects on osteoarthritis. Further studies are required to determine the efficacy of lifestyle-based interventions in reducing the population-wide disease burden of osteoarthritis.

© 2025 Bentham Science Publishers
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The Causal Effects of Lifestyle Factors on Osteoarthritis: A Two-sample Mendelian Randomisation Study
Curr. Rheumatol. Rev. 21, 326 (2025); https://doi.org/10.2174/0115733971335445241203054553
/content/journals/crr/10.2174/0115733971335445241203054553
/content/journals/crr/10.2174/0115733971335445241203054553
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  • Article Type:     Research Article
Keyword(s): BMI; diet; insomnia; lifestyle factors; mendelian randomization; Osteoarthritis

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