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2000
Volume 21, Issue 4
  • ISSN: 1573-3971
  • E-ISSN: 1875-6360

Abstract

Objective

Despite advances in the treatment of Chronic Inflammatory Rheumatic Disease (CIRD), pain remains a significant burden for patients and doctors. This study explored the prevalence and associated factors of central sensitization (CS) in patients with CIRD.

Methods

This is a cross-sectional study that included patients with CIRD followed at the University Hospital Center in Tangier. Sociodemographic and clinical data were collected. Nociceptive pain was assessed by the Visual Analogue Scale (VAS), disease activity by DAS-28 and ASDAS, and CS by the validated Moroccan version of the Central Sensitization Inventory part A (CSI-A). The Pain Catastrophizing Scale (PCS) was used to assess pain-related catastrophic thoughts, and the PHQ-9 (Pain Health Questionnaire) was used to determine the severity of depressive symptoms.

Results

We included 189 patients; 107 (56.61%) had rheumatoid arthritis. The median duration of evolution of CIRD was 8 years, and the mean age was 47.49 ± 13.70 years, and 75.7% were women. The mean pain VAS was 4.77+-2.76, and 37.6% of patients were in remission. The mean central sensitization score was 37.42+- 16.75, with 44.9% having a CSI score ≥ 40. In univariate and multivariate analysis, our study showed that central sensitization is associated with pain severity (β = 1.945(0.050-1.916), = 0.039) and depression (β = 1.790(1.221-2.154), ≤ 0.001)(8). A statistically significant correlation was found between the CSI-A score and pain VAS (r = 0.32, < 0.001).

Conclusion

Our study showed that almost half of our patients with CIRD had CS. The main factors associated with CS in our patients were pain severity and depression. We also found a significant correlation between pain VAS and CSI.

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2024-10-17
2025-09-07

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References

  1. HadiM.A. McHughG.A. ClossS.J. Impact of chronic pain on patients’ quality of life: A comparative mixed-methods study.J. Patient Exp.20196213314110.1177/237437351878601331218259
     [Google Scholar]
  2. WilkM. ZimbaO. HaugebergG. KorkoszM. Pain catastrophizing in rheumatic diseases: Prevalence, origin, and implications.Rheumatol. Int.2024446985100210.1007/s00296‑024‑05583‑838609656
     [Google Scholar]
  3. GulerM.A. CelikO.F. AyhanF.F. The important role of central sensitization in chronic musculoskeletal pain seen in different rheumatic diseases.Clin. Rheumatol.202039126927410.1007/s10067‑019‑04749‑131446538
     [Google Scholar]
  4. IASP. Terminology.2014Available from:https://www.iasp-pain.org/resources/terminology/(accessed on 21-9-2024)
  5. BaillyF. CantagrelA. BertinP. PerrotS. ThomasT. LansamanT. GrangeL. WendlingD. DovicoC. TrouvinA.P. Part of pain labelled neuropathic in rheumatic disease might be rather nociplastic.RMD Open202062e00132610.1136/rmdopen‑2020‑00132632892169
     [Google Scholar]
  6. SchaibleH.G. Nociceptive neurons detect cytokines in arthritis.Arthritis Res. Ther.201416547010.1186/s13075‑014‑0470‑825606597
     [Google Scholar]
  7. VazquezE. KahlenbachJ. Segond von BanchetG. KönigC. SchaibleH.G. EbersbergerA. Spinal interleukin-6 is an amplifier of arthritic pain in the rat.Arthritis Rheum.20126472233224210.1002/art.3438422246633
     [Google Scholar]
  8. LatremoliereA. WoolfC.J. Central sensitization: A generator of pain hypersensitivity by central neural plasticity.J. Pain200910989592610.1016/j.jpain.2009.06.01219712899
     [Google Scholar]
  9. McWilliamsD.F. RahmanS. JamesR.J.E. FergusonE. KielyP.D.W. YoungA. WalshD.A. Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae.BMC Rheumatol.2019314910.1186/s41927‑019‑0100‑931832600
     [Google Scholar]
  10. LeeY.C. CuiJ. LuB. FritsM.L. IannacconeC.K. ShadickN.A. WeinblattM.E. SolomonD.H. Pain persists in DAS28 rheumatoid arthritis remission but not in ACR/EULAR remission: A longitudinal observational study.Arthritis Res. Ther.2011133R8310.1186/ar335321651807
     [Google Scholar]
  11. TrouvinA.P. AttalN. PerrotS. Assessing central sensitization with quantitative sensory testing in inflammatory rheumatic diseases: A systematic review.Joint Bone Spine202289510539910.1016/j.jbspin.2022.10539935504515
     [Google Scholar]
  12. MayerT.G. NeblettR. CohenH. HowardK.J. ChoiY.H. WilliamsM.J. PerezY. GatchelR.J. The development and psychometric validation of the central sensitization inventory.Pain Pract.201212427628510.1111/j.1533‑2500.2011.00493.x21951710
     [Google Scholar]
  13. RolkeR. MagerlW. CampbellK.A. SchalberC. CaspariS. BirkleinF. TreedeR.D. Quantitative sensory testing: A comprehensive protocol for clinical trials.Eur. J. Pain2006101778810.1016/j.ejpain.2005.02.00316291301
     [Google Scholar]
  14. UddinZ. MacDermidJ.C. Quantitative sensory testing in chronic musculoskeletal pain.Pain Med.20161791694e70310.1093/pm/pnv105
     [Google Scholar]
  15. BerrichiI. TaikF.Z. FouziaH. AB1382 impact of central sensitization on pain in patients with chronic inflammatory rheumatic diseases.Ann. Rheum. Dis.2023821920
     [Google Scholar]
  16. NeblettR. CohenH. ChoiY. HartzellM.M. WilliamsM. MayerT.G. GatchelR.J. The Central Sensitization Inventory (CSI): Establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.J. Pain201314543844510.1016/j.jpain.2012.11.01223490634
     [Google Scholar]
  17. AlHadiA.N. AlAteeqD.A. Al-SharifE. BawazeerH.M. AlanaziH. AlShomraniA.T. ShuqdarR.M. AlOwaybilR. An arabic translation, reliability, and validation of Patient Health Questionnaire in a Saudi sample.Ann. Gen. Psychiatry20171613210.1186/s12991‑017‑0155‑128878812
     [Google Scholar]
  18. KieskampS.C. PaapD. CarboM.J.G. WinkF. BosR. BootsmaH. ArendsS. SpoorenbergA. Central sensitization, illness perception and obesity should be considered when interpreting disease activity in axial spondyloarthritis.Rheumatology (Oxford)202160104476448510.1093/rheumatology/keab01933492397
     [Google Scholar]
  19. FilatovaE. PogozhevaE. AmirdzhanovaV. KarateevA. LilaA. AB0165 central sensitization in rheumatoid arthritis.Ann. Rheum. Dis.202180Suppl. 11109.2110910.1136/annrheumdis‑2021‑eular.3074
     [Google Scholar]
  20. ZolioL. LimK.Y. McKenzieJ.E. YanM.K. EsteeM. HussainS.M. CicuttiniF. WlukaA. Systematic review and meta-analysis of the prevalence of neuropathic-like pain and/or pain sensitization in people with knee and hip osteoarthritis.Osteoarthritis Cartilage20212981096111610.1016/j.joca.2021.03.02133971205
     [Google Scholar]
  21. BrennD. RichterF. SchaibleH.G. Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: An inflammatory mechanism of joint pain.Arthritis Rheum.200756135135910.1002/art.2228217195239
     [Google Scholar]
  22. HeislerA.C. SongJ. DunlopD.D. WohlfahrtA. BinghamC.O.III BolsterM.B. ClauwD.J. MarderW. PhillipsK. NeogiT. LeeY.C. Association of pain centralization and patient-reported pain in active rheumatoid arthritis.Arthritis Care Res. (Hoboken)20207281122112910.1002/acr.2399431162824
     [Google Scholar]
  23. LeeY.C. BinghamC.O.III EdwardsR.R. MarderW. PhillipsK. BolsterM.B. ClauwD.J. MorelandL.W. LuB. WohlfahrtA. ZhangZ. NeogiT. Association between pain sensitization and disease activity in patients with rheumatoid arthritis: A cross-sectional study.Arthritis Care Res. (Hoboken)201870219720410.1002/acr.2326628437846
     [Google Scholar]
  24. SalaffiF. CarottiM. FarahS. CeccarelliL. GiovagnoniA. Di CarloM. Early response to JAK inhibitors on central sensitization and pain catastrophizing in patients with active rheumatoid arthritis.Inflammopharmacology20223031119112810.1007/s10787‑022‑00995‑z35505266
     [Google Scholar]
  25. Garcia-HernandezA. De La CobaP. Reyes del PasoG.A. Central sensitisation pain and autonomic deficiencies in fibromyalgia.Clin. Exp. Rheumatol.20224061202120910.55563/clinexprheumatol/n280oi35748717
     [Google Scholar]
  26. GoeslingJ. ClauwD.J. HassettA.L. Pain and depression: an integrative review of neurobiological and psychological factors.Curr. Psychiatry Rep.2013151242110.1007/s11920‑013‑0421‑024214740
     [Google Scholar]
  27. PudD. GranovskyY. YarnitskyD. The methodology of experimentally induced diffuse noxious inhibitory control (DNIC)-like effect in humans.Pain20091441161910.1016/j.pain.2009.02.01519359095
     [Google Scholar]
  28. DafnyN. Pain modulation and mechanisms.Neuroscience online: an electronic textbook for the neurosciences. ByrneJ. DafnyN. HoustonUniversity of Texas Health Science Center at Houston2018
     [Google Scholar]
  29. KroenkeK. BairM.J. DamushT.M. WuJ. HokeS. SutherlandJ. TuW. Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: A randomized controlled trial.JAMA2009301202099211010.1001/jama.2009.72319470987
     [Google Scholar]
  30. ScerboT. ColasurdoJ. DunnS. UngerJ. NijsJ. CookC. Measurement properties of the central sensitization inventory: A systematic review.Pain Pract.201818454455410.1111/papr.1263628851012
     [Google Scholar]
/content/journals/crr/10.2174/0115733971309885241011105213
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Prevalence and Associated Factors of Central Sensitization in Patients with Chronic Inflammatory Rheumatic Disease
Curr. Rheumatol. Rev. 21, 418 (2025); https://doi.org/10.2174/0115733971309885241011105213
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  • Article Type:     Research Article
Keyword(s): Central sensitization; chronic inflammatory rheumatic disease, cross-sectional study, visual analogue scale, depression; pain

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