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2000
Volume 15, Issue 2
  • ISSN: 1573-398X
  • E-ISSN: 1875-6387

Abstract

Alpha-1 antitrypsin deficiency (AATD) or alpha-1 antitrypsin proteinase inhibitor (α1-Pi) deficiency, is a genetic disorder leading to a higher risk of pulmonary, hepatic and other organrelated diseases. The spectrum of diseases associated with AATD is large and includes pulmonary conditions (COPD, asthma, asthma-COPD overlap syndrome, bronchiectasis, etc.) as well as extrapulmonary (liver diseases, systemic vasculitis, rheumatoid arthritis, panniculitis, multiple sclerosis, peripheral neuropathy). We present a review of AATD focusing on its connection to other conditions.

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/content/journals/crmr/10.2174/1573398X15666190617143122
2019-06-01
2025-08-21
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  • Article Type:
    Review Article
Keyword(s): Alpha-1 antitrypsin deficiency; bronchiectasis; COPD; illness; phenotypes; syndrome
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