Markers of Systemic Inflammation in Obstructive Sleep Apnea Syndrome

Obstructive sleep apnea syndrome (OSAS) is a common disorder characterized by recurrent episodes of upper airway obstruction resulting in oxygen desaturations and sleep disruption. OSAS is associated with an augmented risk for cardiovascular and cerebrovascular morbidity and mortality. Several mechanisms have been proposed to explain the association between OSAS and cardiovascular dysfunction. Low-grade systemic inflammation may contribute to the development of the cardiovascular and metabolic diseases associated with OSAS. The purpose of this review is to summarize current evidence on the association between OSAS and markers of systemic inflammation.