s Lung Cancer of Occupational Origin

Lung cancer (LC) is a highly prevalent malignancy mainly caused by long-term exposure to tobacco smoke, although other substances in the workplace can also cause LC. This paper reviews carcinogens in the workplace linked with occupational LC, including asbestos, radon, silica, nickel, beryllium, chromium and polycyclic aromatic hydrocarbons (PAH). In LC of occupational origin, diagnosis can be difficult due to co-exposure to various carcinogens. The present review is intended to provide additional information that may help in the diagnostic approach and discusses controversial issues on certain substances like silica, beryllium or PAH as etiological factors of LC. Finally, occupational LC preventive measures are discussed.