Skip to content
2000
Volume 21, Issue 5
  • ISSN: 1573-398X
  • E-ISSN: 1875-6387

Abstract

Background

Complete or partial collapse of the upper airway for a few seconds during sleep is the cause of obstructive sleep apnea (OSA). OSA affects about half of the world's population. Although there are numerous treatment options for OSA, continuous positive airway pressure (CPAP), mandibular advancement device (MAD), and surgeries are regarded as mainstream therapies.

Objective

Since MAD is a better alternative to CPAP for patients who are unwilling to utilize CPAP therapy or who do not comply with it, our current review focuses on how effective MAD is at managing OSA.

Methods

To find publications relevant to the safety and effectiveness of MAD in the treatment of OSA, online databases such as Medline/PubMed/PMC, Scopus, Web of Science, Google Scholar, and reference lists were searched.

Results

Through the reduction of apnea-hypopnea index (AHI), snoring, and improved sleep quality, a number of prospective and retrospective observational studies, randomized controlled clinical trials and meta-analyses showed that MADs are beneficial for patients with mild-to-moderate OSA and snoring. Although CPAP therapy is the gold standard for treating OSA, patients who cannot or do not want to utilize CPAP therapy may benefit from MAD therapy as an alternative or as a supplementary treatment. For patients with OSA, the use of oral appliances, including MAD, is advised by the American Academy of Sleep Medicine (AASM), American Academy of Dental Sleep Medicine (AADSM), and National Institute of Clinical Excellence (NICE) guidelines.

Conclusion

Numerous randomized controlled clinical trials, prospective and retrospective observational studies, and meta-analyses have demonstrated that MADs are beneficial in treating OSA patients by reducing snoring, enhancing sleep quality, and lowering the apnea-hypopnea index (AHI). A licensed dentist should utilize a custom, titratable MAD when a sleep physician prescribes oral appliance therapy for an adult patient with OSA. The patients managed with MAD therapy should be advised to pay follow-up visits.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/crmr/10.2174/011573398X367489250610162336
2025-06-24
2026-01-07

  • From This Site

    /content/journals/crmr/10.2174/011573398X367489250610162336
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. GodavarthiS PravallikaB TusharaB KrishnapriyaL Review article on sleep apnea.Int. J. Health. Care. Biol. Sci.202121182410.46795/ijhcbs.vi.136
     [Google Scholar]
  2. RautA.D. DixitB. Sleep apnoea disorder: A review.Eur. J. Eng. Technol. Res.20205333934210.24018/ejeng.2020.5.3.1822
     [Google Scholar]
  3. JavaheriS. BarbeF. Campos-RodriguezF. DempseyJ.A. KhayatR. JavaheriS. MalhotraA. Martinez-GarciaM.A. MehraR. PackA.I. PolotskyV.Y. RedlineS. SomersV.K. Sleep apnea: Types, mechanisms, and clinical cardiovascular consequences.J. Am. Coll. Cardiol.20176978418582820922610.1016/j.jacc.2016.11.069.
     [Google Scholar]
  4. SissonC.B. A clinical review of obstructive sleep apnea.JAAPA2023361010153775125010.1097/01.JAA.0000977668.78287.0c.
     [Google Scholar]
  5. PhamL.V. JunJ. PolotskyV.Y. Obstructive sleep apnea.Handb. Clin. Neurol.202218910513610.1016/B978‑0‑323‑91532‑8.00017‑336031300
     [Google Scholar]
  6. AbbasiA. GuptaS.S. SabharwalN. MeghrajaniV. SharmaS. KamholzS. KupferY. A comprehensive review of obstructive sleep apnea.Sleep Sci.20211421421543438157810.5935/1984‑0063.20200056.
     [Google Scholar]
  7. KirschD.B. Obstructive sleep apnea.Continuum (Minneap. Minn.)202026490892810.1212/CON.000000000000088532756228
     [Google Scholar]
  8. RobertsE.G. RaphelsonJ.R. OrrJ.E. LaBuzettaJ.N. MalhotraA. The pathogenesis of central and complex sleep apnea.Curr. Neurol. Neurosci. Rep.202222740541210.1007/s11910‑022‑01199‑235588042
     [Google Scholar]
  9. RanderathW. BaillieulS. TamisierR. Central sleep apnoea: Not just one phenotype.Eur. Respir. Rev.20243317123014110.1183/16000617.0141‑202338537948
     [Google Scholar]
  10. BadrM.S. JavaheriS. JavaheriS. Central sleep apnea: A brief review.Curr. Pulmonol. Rep.201981142110.1007/s13665‑019‑0221‑z31788413
     [Google Scholar]
  11. GinterG. BadrM.S. Central sleep apnea.Handb. Clin. Neurol.20221899310310.1016/B978‑0‑323‑91532‑8.00011‑236031317
     [Google Scholar]
  12. IshikawaO. OksM. Central sleep apnea.Clin. Geriatr. Med.202137346948110.1016/j.cger.2021.04.00934210451
     [Google Scholar]
  13. DempseyJ.A. Central sleep apnea: Misunderstood and mistreated!F1000 Res.2019898110.12688/f1000research.18358.131297185
     [Google Scholar]
  14. ZeineddineS. BadrM.S. Treatment-emergent central apnea: Physiologic mechanisms informing clinical practice.Chest202115962449245710.1016/j.chest.2021.01.03633497650
     [Google Scholar]
  15. ZhangJ. WangL. GuoH.J. WangY. CaoJ. ChenB.Y. Treatment-emergent central sleep apnea: A unique sleep-disordered breathing.Chin. Med. J. (Engl.)2020133222721273010.1097/CM9.000000000000112533009018
     [Google Scholar]
  16. PavsicK. HerkenrathS. TremlM. HagmeyerL. KhayatR.N. HellmichM. RanderathW.J. Mixed apnea metrics in obstructive sleep apnea predict treatment-emergent central sleep apnea.Am. J. Respir. Crit. Care Med.2021203677277510.1164/rccm.202007‑2816LE33233936
     [Google Scholar]
  17. YangX. XiaoY. HanB. LinK. NiuX. ChenX. Implication of mixed sleep apnea events in adult patients with obstructive sleep apnea-hypopnea syndrome.Sleep Breath.201923255956530343435
     [Google Scholar]
  18. YayanJ. RascheK. A systematic review of risk factors for sleep Apnea.Prev. Med. Rep.20244210275010.1016/j.pmedr.2024.10275038741931
     [Google Scholar]
  19. QianY. DharmageS.C. HamiltonG.S. LodgeC.J. LoweA.J. ZhangJ. BowatteG. PerretJ.L. SenaratnaC.V. Longitudinal risk factors for obstructive sleep apnea: A systematic review.Sleep Med. Rev.20237110183810.1016/j.smrv.2023.10183837639973
     [Google Scholar]
  20. MitraA.K. BhuiyanA.R. JonesE.A. Association and risk factors for obstructive sleep apnea and cardiovascular diseases: A systematic review.Diseases2021948810.3390/diseases904008834940026
     [Google Scholar]
  21. ZhouX. LuQ. LiS. PuZ. GaoF. ZhouB. Risk factors associated with the severity of obstructive sleep apnea syndrome among adults.Sci. Rep.2020101135083278227110.1038/s41598‑020‑70286‑6.
     [Google Scholar]
  22. PlatonA.L. SteleaC.G. BoișteanuO. PatrascanuE. ZetuI.N. RoșuS.N. TrifanV. PaladeD.O. An update on obstructive sleep apnea syndrome: A literature review.Medicina (Kaunas)202359814593762974910.3390/medicina59081459.
     [Google Scholar]
  23. SzewczykK. SzewczykB. KrzesłowskaW.J. PytelP. WiśniewskiS. HołowniaW. Health consequences of obstructive sleep apnoea syndrome.J. Educ. Health Sport20247452568
     [Google Scholar]
  24. AzarbarzinA. LabarcaG. KwonY. WellmanA. Physiological consequences of upper airway obstruction in sleep apnea.Chest20241665120912173888589810.1016/j.chest.2024.05.028..
     [Google Scholar]
  25. EspirituJR Health consequences of obstructive sleep apnea.Management of obstructive sleep apnea: An evidence-based, multidisciplinary textbook.Springer20212343
     [Google Scholar]
  26. HardingS.M. Complications and consequences of obstructive sleep apnea.Curr. Opin. Pulm. Med.20006648548910.1097/00063198‑200011000‑0000411100957
     [Google Scholar]
  27. GottliebD.J. PunjabiN.M. Diagnosis and management of obstructive sleep apnea: A review.JAMA2020323141389140032286648
     [Google Scholar]
  28. LarattaC.R. AyasN.T. PovitzM. PendharkarS.R. Diagnosis and treatment of obstructive sleep apnea in adults.CMAJ201718948E1481E14882920361710.1503/cmaj.170296.
     [Google Scholar]
  29. GoyalM. JohnsonJ. Obstructive sleep apnea diagnosis and management.Mol. Med.2017114212012430228558
     [Google Scholar]
  30. QaseemA. DallasP. OwensD.K. StarkeyM. HoltyJ.E. ShekelleP. Diagnosis of obstructive sleep apnea in adults: A clinical practice guideline from the American College of Physicians.Ann. Intern. Med.201416132102202508986410.7326/M12‑3187.
     [Google Scholar]
  31. HuangT. What should the recommendations be for lifestyle factors in obstructive sleep apnea?Expert Rev. Respir. Med.20221666016043579273910.1080/17476348.2022.2099377.
     [Google Scholar]
  32. KaleelullahR.A. NagarajanP.P. Cultivating lifestyle transformations in obstructive sleep apnea.Cureus2021131e1292733659106
     [Google Scholar]
  33. KimJ.W. LimH.J. Lifestyle modification in patients with obstructive sleep apnea.Sleep Med. Res.2018926372
     [Google Scholar]
  34. AraghiM.H. ChenY.F. JagielskiA. ChoudhuryS. BanerjeeD. HussainS. ThomasG.N. TaheriS. Effectiveness of lifestyle interventions on obstructive sleep apnea (OSA): Systematic review and meta-analysis.Sleep201336101553156210.5665/sleep.305624082315
     [Google Scholar]
  35. SwainSK Current medical treatment of obstructive sleep apnoea: A narrative review.Apollo Med.202421510.1177/09760016241252317
     [Google Scholar]
  36. AboussouanL.S. BhatA. CoyT. KominskyA. Treatments for obstructive sleep apnea: CPAP and beyond.Cleve. Clin. J. Med.2023901275576510.3949/ccjm.90a.2303238040437
     [Google Scholar]
  37. DonovanL.M. HoyosC.M. KimoffR.J. MorrellM.J. BoschN.A. ChooljianD.M. McEvoyR.D. SawyerA.M. WagnerT.H. Al-LameeR.R. BishopD. CarnoM.A. EpsteinM. HansonM. IpM.S.M. LétourneauM. PamidiS. PatelS.R. PépinJ.L. PunjabiN.M. RedlineS. ThorntonJ.D. PatilS.P. Strategies to assess the effect of continuous positive airway pressure on long-term clinically important outcomes among patients with symptomatic obstructive sleep apnea: an Official American Thoracic Society Workshop Report.Ann. Am. Thorac. Soc.20232079319433738762410.1513/AnnalsATS.202303‑258ST.
     [Google Scholar]
  38. RanderathW. de LangeJ. HednerJ. HoJ.P.T.F. MarklundM. SchizaS. SteierJ. VerbraeckenJ. Current and novel treatment options for obstructive sleep apnoea.ERJ Open Res.20228200126020223576941710.1183/23120541.00126‑2022.
     [Google Scholar]
  39. PatilS.P. AyappaI.A. CaplesS.M. KimoffR.J. PatelS.R. HarrodC.G. Treatment of adult obstructive sleep apnea with positive airway pressure: An American Academy of Sleep Medicine clinical practice guideline.J. Clin. Sleep Med.201915233534310.5664/jcsm.764030736887
     [Google Scholar]
  40. ZhaS. YangH. YueF. ZhangQ. HuK. Combined noradrenergic plus antimuscarinic agents for obstructive sleep apnea: A systematic review and meta-analysis of randomized controlled trials.Sleep Med. Rev.20226410164910.1016/j.smrv.2022.10164935709641
     [Google Scholar]
  41. LeeY.C. LuC.T. ChuangL.P. LeeL.A. FangT.J. ChengW.N. LiH.Y. Pharmacotherapy for obstructive sleep apnea: A systematic review and meta-analysis of randomized controlled trials.Sleep Med. Rev.20237010180910.1016/j.smrv.2023.10180937423095
     [Google Scholar]
  42. NobreM.L. SarmentoA.C.A. de OliveiraP.F. WanderleyF.F. Diniz JúniorJ. GonçalvesA.K. Pharmacological treatment for obstructive sleep apnea: A systematic review and meta-analysis.Clinics (São Paulo)20247910033010.1016/j.clinsp.2024.10033038341903
     [Google Scholar]
  43. PanahiL. UdeaniG. HoS. KnoxB. MailleJ. Review of the management of obstructive sleep apnea and pharmacological symptom management.Medicina (Kaunas)20215711117310.3390/medicina5711117334833390
     [Google Scholar]
  44. ArredondoE. DeLeonM. MasozeraI. PanahiL. UdeaniG. TranN. NguyenC.K. AtphaisitC. de la SotaB. GonzalezG.Jr LiouE. MayoZ. NwosuJ. ShiverT.L. Overview of the role of pharmacological management of obstructive sleep apnea.Medicina (Kaunas)202258222510.3390/medicina5802022535208549
     [Google Scholar]
  45. NeshatS.S. HeidariA. Henriquez-BeltranM. PatelK. ColacoB. ArunthariV. Lee MateusA.Y. CheungJ. LabarcaG. Evaluating pharmacological treatments for excessive daytime sleepiness in obstructive sleep apnea: A comprehensive network meta-analysis and systematic review.Sleep Med. Rev.2024761019343875420810.1016/j.smrv.2024.101934.
     [Google Scholar]
  46. TserenpilG. GebreM. ZerghamA.S. SekhonA.K. MalikB.H. Managements for obstructive sleep apnea in adults.Cureus2020128e990510.7759/cureus.990532968568
     [Google Scholar]
  47. MorrowL.E. MaleskerM.A. Surgical procedures for obstructive sleep apnea.US Pharm.201843HS2HS7
     [Google Scholar]
  48. CarvalhoB. HsiaJ. CapassoR. Surgical therapy of obstructive sleep apnea: A review.Neurotherapeutics20129471071622915293
     [Google Scholar]
  49. RezaieL. MaazinezhadS. FogelbergD.J. KhazaieH. Sadeghi-BahmaniD. BrandS. Compared to individuals with mild to moderate obstructive sleep apnea (OSA), individuals with severe OSA had higher BMI and respiratory-disturbance scores.Life202111536810.3390/life1105036833919250
     [Google Scholar]
  50. BarattaF. PastoriD. BucciT. FabianiM. FabianiV. BrunoriM. LoffredoL. LilloR. PannitteriG. AngelicoF. Del BenM. Long-term prediction of adherence to continuous positive air pressure therapy for the treatment of moderate/severe obstructive sleep apnea syndrome.Sleep Med.201843667010.1016/j.sleep.2017.09.03229482815
     [Google Scholar]
  51. VerbraeckenJ. DieltjensM. Op de BeeckS. VroegopA. BraemM. VandervekenO. RanderathW. Non-CPAP therapy for obstructive sleep apnoea.Breathe (Sheff.)202218322016436340820
     [Google Scholar]
  52. FrancisC.E. QuinnellT. Mandibular advancement devices for OSA: An alternative to CPAP?Pulm. Ther.202171253633170490
     [Google Scholar]
  53. Lo GiudiceA. La RosaS. RonsivalleV. IsolaG. CicciùM. Alessandri-BonettiG. LeonardiR. Indications for dental specialists for treating obstructive sleep apnea with mandibular advancement devices: A narrative review.Int. J. Dent.202420241100723710.1155/2024/100723738585252
     [Google Scholar]
  54. ManettaIP EttlinD SanzPM RochaI CruzMM Mandibular advancement devices in obstructive sleep apnea: An updated review.Sleep Sci202215S0239840510.5935/1984‑0063.20210032.
     [Google Scholar]
  55. De MeyerM.M.D. VandervekenO.M. De WeerdtS. MarksL.A.M. CárcamoB.A. ChavezA.M. MatamorosF.A. JacquetW. Use of mandibular advancement devices for the treatment of primary snoring with or without obstructive sleep apnea (OSA): A systematic review.Sleep Med. Rev.20215610140710.1016/j.smrv.2020.10140733326914
     [Google Scholar]
  56. ByunJ.S. JungJ.K. Mandibular advancement devices for treating snoring and obstructive sleep apnea.J. Oral Med. Pain2014392354510.14476/jomp.2014.39.2.35
     [Google Scholar]
  57. Lo GiudiceA. La RosaS. PalazzoG. FedericoC. Diagnostic and therapeutic indications of different types of mandibular advancement design for patients with obstructive sleep apnea syndrome: Indications from literature review and case descriptions.Diagnostics20241417191510.3390/diagnostics1417191539272700
     [Google Scholar]
  58. YangJ. RosenmöllerB.R.A.M. van RietT.C.T. TanM.L. JamaludinF.S. HoJ.P.T.F. de LangeJ. Smart mandibular advancement devices for obstructive sleep apnea: A systematic literature review.Sleep Breath.20242851879188710.1007/s11325‑024‑03068‑338886278
     [Google Scholar]
  59. Uniken VenemaJ.A.M. RosenmöllerB.R.A.M. de VriesN. de LangeJ. AarabG. LobbezooF. HoekemaA. Mandibular advancement device design: A systematic review on outcomes in obstructive sleep apnea treatment.Sleep Med. Rev.20216010155710.1016/j.smrv.2021.10155734662769
     [Google Scholar]
  60. BernhardtO. GiannakopoulosN.N. HeiseM. MeyerA. NordenD. SchlieperJ. KaresH. Mandibular advancement device: prescription in adult dental sleep medicine — guideline of the German Society of Dental Sleep Medicine.Sleep Breath.202327138939710.1007/s11325‑022‑02601‑635349009
     [Google Scholar]
  61. MezzofrancoL. GraccoA.L.T. MilanoF. Di-BernardoG.A. VezzaliL. GiovanniniD. Personality traits and oral device: A new challenge to increase compliance with MAD therapy for OSAS and snoring.Sleep Sci.2020131101732670487
     [Google Scholar]
  62. BartolucciM.L. BortolottiF. CorazzaG. IncertiP.S. PaganelliC. AlessandriB.G. Effectiveness of different mandibular advancement device designs in obstructive sleep apnoea therapy: A systematic review of randomised controlled trials with meta-analysis.J. Oral Rehabil.202148446948610.1111/joor.1307732805753
     [Google Scholar]
  63. Camañes-GonzalvoS. Bellot-ArcísC. Marco-PitarchR. Montiel-CompanyJ.M. García-SelvaM. Agustín-PanaderoR. Paredes-GallardoV. Puertas-CuestaF.J. Comparison of the phenotypic characteristics between responders and non-responders to obstructive sleep apnea treatment using mandibular advancement devices in adult patients: Systematic review and meta-analysis.Sleep Med. Rev.20226410164410.1016/j.smrv.2022.10164435653952
     [Google Scholar]
  64. BasyuniS. BarabasM. QuinnellT. An update on mandibular advancement devices for the treatment of obstructive sleep apnoea hypopnoea syndrome.J. Thorac. Dis.201810S1S48S5610.21037/jtd.2017.12.1829445528
     [Google Scholar]
  65. HuangW. LaiH. Effect of exercise versus mandibular advancement device in moderate obstructive sleep apnea patients with mandibular retrognathia: A randomized clinical trial.Cranio2024311010.1080/08869634.2024.240164339306757
     [Google Scholar]
  66. GuichaouaC. DugastS. DerrienA. BoudaudP. ChauxA.G. BertinH. CorreP. Evaluation of the efficacy of a custom-made monoblock mandibular advancement device in treatment of obstructive sleep apnea hypopnea syndrome.J. Stomatol. Oral Maxillofac. Surg.2024125410174310.1016/j.jormas.2023.10174338128880
     [Google Scholar]
  67. GogouE.S. PsarrasV. GiannakopoulosN.N. MinaritzoglouA. TsolakisI.A. MargaritisV. TzakisM.G. Comparing efficacy of the mandibular advancement device after drug-induced sleep endoscopy and continuous positive airway pressure in patients with obstructive sleep apnea.Sleep Breath.202428277378810.1007/s11325‑023‑02958‑238085497
     [Google Scholar]
  68. CremoniniF. PomaG. PaloneM. PellitteriF. GuidorziJ. ColabianchiV. StomeoF. LombardoL. Treatment of obstructive sleep apnea and simple snoring: Efficacy of a new mandibular advancement device.Appl. Sci.20241410405210.3390/app14104052
     [Google Scholar]
  69. SangalliL. Yanez-RegonesiF. Moreno-HayI. Evolution of adherence and self-reported symptoms over 36 months with mandibular advancement device therapy for obstructive sleep apnea: A retrospective study.J. Clin. Sleep Med.202420448749610.5664/jcsm.1090037909061
     [Google Scholar]
  70. AnituaE. MayoralP. AlmeidaG.Z. Durán-CantollaJ. AlkhraisatM.H. A multicenter prospective study on the use of a mandibular advancement device in the treatment of obstructive sleep apnea.Dent. J.2023111124710.3390/dj1111024737999010
     [Google Scholar]
  71. BelkhodeV. GodboleS. NimonkarS. PisulkarS. NimonkarP. Comparative evaluation of the efficacy of customized maxillary oral appliance with mandibular advancement appliance as a treatment modality for moderate obstructive sleep apnea patients: A randomized controlled trial.Trials20232417310.1186/s13063‑022‑07054‑636726182
     [Google Scholar]
  72. VecchieriniM.F. AttaliV. ColletJ.M. d’OrthoM.P. GoutorbeF. KerbratJ.B. LegerD. LavergneF. MonacaC. MonteyrolP.J. MullensE. PigeariasB. MartinF. KhemlicheH. LerousseauL. MeuriceJ.C. Mandibular advancement device use in obstructive sleep apnea: ORCADES study 5-year follow-up data.J. Clin. Sleep Med.20211781695170510.5664/jcsm.930834165074
     [Google Scholar]
  73. de VriesG.E. HoekemaA. VermeulenK.M. ClaessenJ.Q.P.J. JacobsW. van der MatenJ. van der HoevenJ.H. StegengaB. KerstjensH.A.M. WijkstraP.J. Clinical-and cost-effectiveness of a mandibular advancement device versus continuous positive airway pressure in moderate obstructive sleep apnea.J. Clin. Sleep Med.201915101477148510.5664/jcsm.798031596213
     [Google Scholar]
  74. QuinnellT.G. BennettM. JordanJ. Clutterbuck-JamesA.L. DaviesM.G. Smithi.e. OscroftN. PittmanM.A. CameronM. ChadwickR. MorrellM.J. GloverM.J. Fox-RushbyJ.A. SharplesL.D. A crossover randomised controlled trial of oral mandibular advancement devices for obstructive sleep apnoea-hypopnoea (TOMADO).Thorax2014691093894510.1136/thoraxjnl‑2014‑20546425035126
     [Google Scholar]
  75. SharplesL. GloverM. Clutterbuck-JamesA. BennettM. JordanJ. ChadwickR. PittmanM. EastC. CameronM. DaviesM. OscroftN. SmithI. MorrellM. Fox-RushbyJ. QuinnellT. Clinical effectiveness and cost-effectiveness results from the randomised controlled Trial of Oral Mandibular Advancement Devices for Obstructive sleep apnoea–hypopnoea (TOMADO) and long-term economic analysis of oral devices and continuous positive airway pressure.Health Technol. Assess.20141867129610.3310/hta1867025359435
     [Google Scholar]
  76. LiaoJ. ShiY. GaoX. ZhangB. LiY. XuW. HanD. Efficacy of oral appliance for mild, moderate, and severe obstructive sleep apnea: A meta-analysis.Otolaryngol. Head Neck Surg.202417051270127910.1002/ohn.67638363016
     [Google Scholar]
  77. Belanche MonterdeA. Zubizarreta-MachoÁ. Lobo GalindoA.B. Albaladejo MartínezA. Montiel-CompanyJ.M. Mandibular advancement devices decrease systolic pressure during the day and night in patients with obstructive sleep apnea: A systematic review and meta-analysis.Sleep Breath.20242831037104910.1007/s11325‑023‑02984‑038180683
     [Google Scholar]
  78. GuoM.Y. LiP.J. XiaoY. CaoY. LiangZ.A. Effectiveness of mandibular advancement devices in the treatment of obstructive sleep apnea and the impact of different body positions on treatment: A systematic review and meta-analysis.Sleep Med.202411327528338071926
     [Google Scholar]
  79. YuM. MaY. HanF. GaoX. Long-term efficacy of mandibular advancement devices in the treatment of adult obstructive sleep apnea: A systematic review and meta-analysis.PLoS One20231811e029283238015938
     [Google Scholar]
  80. BeriA. PisulkarS.G. DubeyS.A. SatheS. BansodA. ShrivastavaA. Appliances therapy in obstructive sleep Apnoea: A systematic review and meta-analysis.Cureus20231511e4828010.7759/cureus.4828038058324
     [Google Scholar]
  81. BartolucciM.L. BortolottiF. RaffaelliE. D’AntòV. MichelottiA. AlessandriB.G. The effectiveness of different mandibular advancement amounts in OSA patients: A systematic review and meta-regression analysis.Sleep Breath.201620391191926779903
     [Google Scholar]
  82. van der HoekL.H. RosenmöllerB.R.A.M. van de RijtL.J.M. de VriesR. AarabG. LobbezooF. Factors associated with treatment adherence to mandibular advancement devices: A scoping review.Sleep Breath.20232762527254437386300
     [Google Scholar]
  83. BortolottiF. CorazzaG. BartolucciM.L. IncertiP.S. PaganelliC. Alessandri-BonettiG. Dropout and adherence of obstructive sleep apnoea patients to mandibular advancement device therapy: A systematic review of randomised controlled trials with meta-analysis and meta-regression.J. Oral Rehabil.202249555357234865235
     [Google Scholar]
  84. ChenH. EckertD.J. van der SteltP.F. GuoJ. GeS. EmamiE. AlmeidaF.R. HuynhN.T. Phenotypes of responders to mandibular advancement device therapy in obstructive sleep apnea patients: A systematic review and meta-analysis.Sleep Med. Rev.20204910122931785583
     [Google Scholar]
  85. ParkK.J. KimS.T. Long-term side effects of mandibular advancement devices in patients with obstructive sleep apnea.J. Sleep Medicine.20191626770
     [Google Scholar]
  86. BartolucciM.L. BortolottiF. MartinaS. CorazzaG. MichelottiA. Alessandri-BonettiG. Dental and skeletal long-term side effects of mandibular advancement devices in obstructive sleep apnea patients: A systematic review with meta-regression analysis.Eur. J. Orthod.20194118910029901715
     [Google Scholar]
  87. YuM. MaY. GongX.U. GaoX. Dental and skeletal changes of long-term use of mandibular advancement devices for the treatment of adult obstructive sleep apnea: A systematic review and meta-analysis.J. Evid. Based Dent. Pract.202424310199139174171
     [Google Scholar]
  88. RanaA. RautA. MathurA. The Occlusal side effects of mandibular advancement device therapy in adult sleep apnea patients: A systematic review.Cureus20231511e4868238090465
     [Google Scholar]
  89. TsolakisI.A. PalomoJ.M. MatthaiosS. TsolakisA.I. Dental and skeletal side effects of oral appliances used for the treatment of obstructive sleep apnea and snoring in adult patients-a systematic review and meta-analysis.J. Pers. Med.202212348335330482
     [Google Scholar]
  90. MickelsonS.A. Oral appliances for snoring and obstructive sleep apnea.Otolaryngol. Clin. North Am.202053339740732223982
     [Google Scholar]
  91. NgiamJ. BalasubramaniamR. DarendelilerM.A. ChengA.T. WatersK. SullivanC.E. Clinical guidelines for oral appliance therapy in the treatment of snoring and obstructive sleep apnoea.Aust. Dent. J.201358440841924320895
     [Google Scholar]
  92. VimalJ. DuttP. SinghN. SinghB.P. ChandP. JurelS. To compare different non-surgical treatment modalities on treatment of obstructive sleep apnea: A systematic review and meta-analysis.J. Indian Prosthodont. Soc.202222431432736511065
     [Google Scholar]
  93. PattipatiM. GudavalliG. ZinM. DhulipallaL. KolackE. KarkiM. DevarakondaP.K. YoeL. Continuous positive airway pressure vs mandibular advancement devices in the treatment of obstructive sleep apnea: an updated systematic review and meta-analysis.Cureus2022141e2175910.7759/cureus.2175935251830
     [Google Scholar]
  94. TrzepizurW. CistulliP.A. GlosM. VielleB. SutherlandK. WijkstraP.J. HoekemaA. GagnadouxF. Health outcomes of continuous positive airway pressure versus mandibular advancement device for the treatment of severe obstructive sleep apnea: An individual participant data meta-analysis.Sleep2021447zsab01510.1093/sleep/zsab01533493338
     [Google Scholar]
  95. LiP. NingX.H. LinH. ZhangN. GaoY.F. PingF. Continuous positive airway pressure versus mandibular advancement device in the treatment of obstructive sleep apnea: A systematic review and meta-analysis.Sleep Med.20207251110.1016/j.sleep.2020.03.01532534403
     [Google Scholar]
  96. SchwartzM. AcostaL. HungY.L. PadillaM. EncisoR. Effects of CPAP and mandibular advancement device treatment in obstructive sleep apnea patients: A systematic review and meta-analysis.Sleep Breath.201822355556810.1007/s11325‑017‑1590‑629129030
     [Google Scholar]
  97. SharplesL.D. Clutterbuck-JamesA.L. GloverM.J. BennettM.S. ChadwickR. PittmanM.A. QuinnellT.G. Meta-analysis of randomised controlled trials of oral mandibular advancement devices and continuous positive airway pressure for obstructive sleep apnoea-hypopnoea.Sleep Med. Rev.20162710812410.1016/j.smrv.2015.05.00326163056
     [Google Scholar]
  98. RamarK. DortL.C. KatzS.G. LettieriC.J. HarrodC.G. ThomasS.M. ChervinR.D. Clinical practice guideline for the treatment of obstructive sleep apnea and snoring with oral appliance therapy: An update for 2015: An American Academy of Sleep Medicine and American Academy of Dental Sleep Medicine clinical practice guideline.J. Clin. Sleep Med.201511777382710.5664/jcsm.485826094920
     [Google Scholar]
  99. LeeY. LeeJ.Y. ChoiJ.H. Oral appliance therapy for obstructive Sleep Apnea: Clinical benefits and limitations.Sleep Med. Res.202314417518210.17241/smr.2023.01921
     [Google Scholar]
/content/journals/crmr/10.2174/011573398X367489250610162336
Loading
Mandibular Advancement Devices’ Efficacy in Treating Obstructive Sleep Apnea - An Overview of Clinical Data
Curr. Respir. Med. Rev. 21, 449 (2025); https://doi.org/10.2174/011573398X367489250610162336
/content/journals/crmr/10.2174/011573398X367489250610162336
/content/journals/crmr/10.2174/011573398X367489250610162336
Loading

Data & Media loading...


  • Article Type:     Review Article
Keyword(s): apnea-hypopnea index (AHI); continuous positive airway pressure (CPAP); mandibular advancement device (MAD); mandibular advancement splints (MAS); mandibular repositioning appliances (MRA); Obstructive sleep apnea

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test