Skip to content
2000
image of Parvovirus B19 Intrauterine Infection and Cerebral Cortical Dysplasia: A Case Report

Abstract

Background

Intrauterine parvovirus B19 infection usually causes fetal anemia, hydrops, and stillbirth. Less commonly, central nervous system injuries have also been described.

Case Presentation

We report an atypical case of severe brain injury with diffuse malformation of cortical development and severely immature gyration in a preterm infant with profound fetal anemia and hydrops due to congenital parvovirus B19 infection. The fetus was treated with multiple intrauterine transfusions. Postnatal magnetic resonance imaging of the brain showed extensive encephalomalacia with severe volume loss of both hemispheres, associated with a deranged, markedly immature gyration.

Conclusion

This case provides the first description of severe delay in brain maturation in intrauterine parvovirus B19 infection and represents evidence of a possible teratogenic effect of parvovirus B19 on the brain tissue.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cpr/10.2174/0115733963349333250407065521
2025-04-14
2025-10-31

  • From This Site

    /content/journals/cpr/10.2174/0115733963349333250407065521
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Heegaard E.D. Brown K.E. Human Parvovirus B19. Clin. Microbiol. Rev. 2002 15 3 485 505 10.1128/CMR.15.3.485‑505.2002 12097253
    [Google Scholar]
  2. Ornoy A. Ergaz Z. Parvovirus B19 infection during pregnancy and risks to the fetus. Birth Defects Res. 2017 109 5 311 323 10.1002/bdra.23588 28398685
    [Google Scholar]
  3. Anderson M.J. Higgins P.G. Davis L.R. Willman J.S. Jones S.E. Kidd I.M. Pattison J.R. Tyrrell D.A.J. Experimental parvoviral infection in humans. J. Infect. Dis. 1985 152 2 257 265 10.1093/infdis/152.2.257 2993431
    [Google Scholar]
  4. Morel O. Chagnaud S. Laperrelle J. Clément D. Malartic C. Akerman G. Tulpin L. Sitbon M. Barranger E. Parvovirus B19 in pregnancy: Literature review. Gynécol. Obstét. Fertil. 2007 35 11 1095 1104 10.1016/j.gyobfe.2007.07.036 18006356
    [Google Scholar]
  5. Gratacós E. Torres P.J. Vidal J. Antolín E. Costa J. Jiménez de Anta M.T. Cararach V. Alonso P.L. Fortuny A. The incidence of human parvovirus B19 infection during pregnancy and its impact on perinatal outcome. J. Infect. Dis. 1995 171 5 1360 1363 10.1093/infdis/171.5.1360 7751717
    [Google Scholar]
  6. de Jong E.P. de Haan T.R. Kroes A.C.M. Beersma M.F.C. Oepkes D. Walther F.J. Parvovirus B19 infection in pregnancy. J. Clin. Virol. 2006 36 1 1 7 10.1016/j.jcv.2006.01.004 16488187
    [Google Scholar]
  7. Crane J. Mundle W. Boucoiran I. Gagnon R. Bujold E. Basso M. Bos H. Brown R. Cooper S. Gouin K. McLeod N.L. Menticoglou S. Mundle W. Pylypjuk C. Roggensack A. Sanderson F. Parvovirus B19 infection in pregnancy. J. Obstet. Gynaecol. Can. 2014 36 12 1107 1116 10.1016/S1701‑2163(15)30390‑X 25668048
    [Google Scholar]
  8. Bascietto F. Liberati M. Murgano D. Buca D. Iacovelli A. Flacco M.E. Manzoli L. Familiari A. Scambia G. D’Antonio F. Outcome of fetuses with congenital parvovirus B19 infection: Systematic review and meta‐analysis. Ultrasound Obstet. Gynecol. 2018 52 5 569 576 10.1002/uog.19092 29785793
    [Google Scholar]
  9. Isumi H. Nunoue T. Nishida A. Takashima S. Fetal brain infection with human parvovirus B19. Pediatr. Neurol. 1999 21 3 661 663 10.1016/S0887‑8994(99)00055‑7 10513695
    [Google Scholar]
  10. Enders M. Weidner A. Zoellner I. Searle K. Enders G. Fetal morbidity and mortality after acute human parvovirus B19 infection in pregnancy: Prospective evaluation of 1018 cases. Prenat. Diagn. 2004 24 7 513 518 10.1002/pd.940 15300741
    [Google Scholar]
  11. Glenn O.A. Bianco K. Barkovich A.J. Callen P.W. Parer J.T. Fetal cerebellar hemorrhage in parvovirus-associated non-immune hydrops fetalis. J. Matern. Fetal Neonatal Med. 2007 20 10 769 772 10.1080/14767050701580960 17763280
    [Google Scholar]
  12. Sanapo L. Wien M. Whitehead M.T. Blask A. Gallagher M. DeBiasi R.L. Du Plessis A. Fetal anemia, cerebellar hemorrhage and hypoplasia associated with congenital Parvovirus infection. J. Matern. Fetal Neonatal Med. 2017 30 16 1887 1890 10.1080/14767058.2016.1228103 27558443
    [Google Scholar]
  13. Pistorius L.R. Smal J. de Haan T.R. Page-Christiaens G.C.M.L. Verboon-Maciolek M. Oepkes D. de Vries L.S. Disturbance of cerebral neuronal migration following congenital parvovirus B19 infection. Fetal Diagn. Ther. 2008 24 4 491 494 10.1159/000180119 19060481
    [Google Scholar]
  14. Courtier J. Schauer G.M. Parer J.T. Regenstein A.C. Callen P.W. Glenn O.A. Polymicrogyria in a fetus with human parvovirus B19 infection: A case with radiologic–pathologic correlation. Ultrasound Obstet. Gynecol. 2012 40 5 604 606 10.1002/uog.11121 22344957
    [Google Scholar]
  15. Schulert G. Walsh W. Weitkamp J.H. Polymicrogyria and congenital parvovirus b19 infection. AJP Rep. 2011 1 2 105 110 10.1055/s‑0031‑1285984 23705097
    [Google Scholar]
  16. Katz V. McCoy M. Kuller J. Hansen W. An association between fetal parvovirus B19 infection and fetal anomalies: A report of two cases. Am. J. Perinatol. 1996 13 1 43 45 10.1055/s‑2007‑994201 8645385
    [Google Scholar]
  17. Craze J.L. Salisbury A.J. Pike M.G. Prenatal stroke associated with maternal parvovirus infection. Dev. Med. Child Neurol. 1996 38 1 84 85 8606021
    [Google Scholar]
  18. De Haan T.R. Van Wezel-Meijler G. Beersma M.F.C. von Lindern J.S. Van Duinen S.G. Walther F.J. Fetal stroke and congenital parvovirus B19 infection complicated by activated protein C resistance. Acta Paediatr. 2006 95 7 863 867 10.1111/j.1651‑2227.2006.tb02356.x 16801187
    [Google Scholar]
  19. Plachouras N. Stefanidis K. Andronikou S. Lolis D. Severe nonimmune hydrops fetalis and congenital corneal opacification secondary to human parvovirus B19 infection. A case report. J. Reprod. Med. 1999 44 4 377 380 10319311
    [Google Scholar]
  20. Van Elsacker-Niele A.M.W. Salimans M.M.M. Wetland H.T. Vermey-Keers C. Anderson M.J. Versteeg J. Fetal pathology in human parvovirus B19 infection. BJOG 1989 96 7 768 775 10.1111/j.1471‑0528.1989.tb03314.x 2548567
    [Google Scholar]
  21. Hartwig N.G. Vermeij-Keers C. Versteeg J. The anterior eye segment in virus induced primary congenital aphakia. Acta Morphol. Neerl. Scand. 1988 26 4 283 292 2855967
    [Google Scholar]
  22. Volpe J.J. Brain injury in premature infants: A complex amalgam of destructive and developmental disturbances. Lancet Neurol. 2009 8 1 110 124 10.1016/S1474‑4422(08)70294‑1 19081519
    [Google Scholar]
  23. Volpe J.J. The encephalopathy of prematurity--brain injury and impaired brain development inextricably intertwined. Semin. Pediatr. Neurol. 2009 16 4 167 178 10.1016/j.spen.2009.09.005 19945651
    [Google Scholar]
  24. Chi J.G. Dooling E.C. Gilles F.H. Gyral development of the human brain. Ann. Neurol. 1977 1 1 86 93 10.1002/ana.410010109 560818
    [Google Scholar]
  25. Meijler G. Steggerda S.J. Neonatal Cranial Ultrasonography. 3rd ed Cham, Switzerland Springer 2019 10.1007/978‑3‑319‑77815‑0
    [Google Scholar]
  26. Carbonne B. Nguyen A. Cynober E. Castaigne V. Cortey A. Brossard Y. Prenatal diagnosis of anoxic cerebral lesions caused by profound fetal anemia secondary to maternal red blood cell alloimmunization. Obstet. Gynecol. 2008 112 2 442 444 10.1097/AOG.0b013e3181656a11 18669757
    [Google Scholar]
  27. Simonazzi G. Bernabini D. Curti A. Bisulli M. Pilu G. Brill C.B. Rizzo N. Berghella V. Fetal cerebellar damage in fetuses with severe anemia undergoing intrauterine transfusions. J. Matern. Fetal Neonatal Med. 2016 29 3 389 392 10.3109/14767058.2014.1001973 25579117
    [Google Scholar]
  28. Maisonneuve E. Garel C. Friszer S. Pénager C. Carbonne B. Pernot F. Rozenberg F. Schnuriger A. Cortey A. Moutard M.L. Jouannic J.M. Fetal brain injury associated with parvovirus B19 congenital infection requiring intrauterine transfusion. Fetal Diagn. Ther. 2019 46 1 1 11 10.1159/000489881 30032153
    [Google Scholar]
  29. Govaert P. de Vries L.S. An Atlas of Neonatal Brain Sonography. 2nd ed London, England Mac Keith Press 2010
    [Google Scholar]
  30. Rodis J. Rodner C. Hansen A.A. Borgida A.F. Deoliveira I. Shulman Rosengren S. Long-term outcome of children following maternal human parvovirus B19 infection. Obstet. Gynecol. 1998 91 1 125 128 10.1016/S0029‑7844(97)00575‑9 9464735
    [Google Scholar]
  31. Dembinski J. Haverkamp F. Maara H. Hansmann M. Eis-Hübinger A.M. Bartmann P. Neurodevelopmental outcome after intrauterine red cell transfusion for parvovirus B19-induced fetal hydrops. BJOG 2002 109 11 1232 1234 12452460
    [Google Scholar]
  32. Cameron A.D. Swain S. Patrick W.J.A. Human parvovirus B19 infection associated with hydrops fetalis. Aust. N. Z. J. Obstet. Gynaecol. 1997 37 3 316 319 10.1111/j.1479‑828X.1997.tb02419.x 9325515
    [Google Scholar]
  33. Miller E. Fairley C.K. Cohen B.J. Seng C. Immediate and long term outcome of human parvovirus B19 infection in pregnancy. BJOG 1998 105 2 174 178 10.1111/j.1471‑0528.1998.tb10048.x 9501782
    [Google Scholar]
  34. Welcker S. Heckmann M. Non-immune Hydrops fetalis due to Parvovirus B19 infection in 2 extremely preterm infants: Perinatal management and long-term neurodevelopmental outcome. Z. Geburtshilfe Neonatol. 2015 219 3 144 147 10.1055/s‑0034‑1395538 25830498
    [Google Scholar]
  35. Berezowsky A. Hochberg A. Regev N. Weisz B. Lipitz S. Yinon Y. Intrauterine blood transfusion for parvo B19-induced fetal anemia: Neuroimaging findings and long-term neurological outcomes. Fetal Diagn. Ther. 2023 50 3 206 214 10.1159/000530993 37231949
    [Google Scholar]
  36. De Jong E.P. Lindenburg I.T. van Klink J.M. Oepkes D. van Kamp I.L. Walther F.J. Lopriore E. Intrauterine transfusion for parvovirus B19 infection: long-term neurodevelopmental outcome. Am. J. Obstet. Gynecol. 2012 206 3 204.e1 204.e5 10.1016/j.ajog.2011.12.035 22381602
    [Google Scholar]
  37. Nagel H.T.C. de Haan T.R. Vandenbussche F.P.H.A. Oepkes D. Walther F.J. Long-term outcome after fetal transfusion for hydrops associated with parvovirus B19 infection. Obstet. Gynecol. 2007 109 1 42 47 10.1097/01.AOG.0000249611.67873.94 17197586
    [Google Scholar]
  38. Lindenburg I.T.M. van Klink J.M. Smits-Wintjens V.E.H.J. van Kamp I.L. Oepkes D. Lopriore E. Long‐term neurodevelopmental and cardiovascular outcome after intrauterine transfusions for fetal anaemia:A review. Prenat. Diagn. 2013 33 9 815 822 10.1002/pd.4152 23658134
    [Google Scholar]
  39. Kielaite D. Paliulyte V. Parvovirus (B19) infection during pregnancy: Possible effect on the course of pregnancy and rare fetal outcomes. A case report and literature review. Medicina (Kaunas) 2022 58 5 664 10.3390/medicina58050664 35630081
    [Google Scholar]
  40. Fortin O. DeBiasi R.L. Mulkey S.B. Congenital infectious encephalopathies from the intrapartum period to postnatal life. Semin. Fetal Neonatal Med. 2024 29 1 101526 10.1016/j.siny.2024.101526 38677956
    [Google Scholar]
  41. Kerr J.R. Barah F. Chiswick M.L. McDonnell G.V. Smith J. Chapman M.D. Bingham J.B. Kelleher P. Sheppard M.N. Evidence for the role of demyelination, HLA-DR alleles, and cytokines in the pathogenesis of parvovirus B19 meningoencephalitis and its sequelae. J. Neurol. Neurosurg. Psychiatry 2002 73 6 739 746 10.1136/jnnp.73.6.739 12438480
    [Google Scholar]
/content/journals/cpr/10.2174/0115733963349333250407065521
Loading
Parvovirus B19 Intrauterine Infection and Cerebral Cortical Dysplasia: A Case Report
Bentham Science Publishers ; https://doi.org/10.2174/0115733963349333250407065521
/content/journals/cpr/10.2174/0115733963349333250407065521
/content/journals/cpr/10.2174/0115733963349333250407065521
Loading

Data & Media loading...


  • Article Type:     Case Report
Keywords: Parvovirus B19 ; fetal anemia ; nervous system malformations ; magnetic resonance imaging ; congenital infection ; newborn

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test