Skip to content
2000
image of Primary Renal Neuroblastoma: A Case Report and Review of the Literature

Abstract

Introduction

Neuroblastoma is the most common extracranial solid tumor found in childhood.

Case Representation

Primary renal neuroblastoma has been reported in the literature as case reports. Almost all cases had a preliminary diagnosis of Wilms tumor and were diagnosed as neuroblastoma after nephrectomy. Renal localized neuroblastoma may not be distinguished radiologically from Wilms tumor.

Discussion

We report a case of a 9-month-old infant with primary intrarenal neuroblastoma and provide a literature review. The definitive differential diagnosis of some renal masses is both radiologically and clinically challenging.

Conclusion

In such cases, the input of a multidisciplinary team, including the oncologist, surgeon, and radiologist, is invaluable in deciding on a biopsy or nephrectomy.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/cpr/10.2174/0115733963321945241118113026
2025-01-02
2025-09-13

  • From This Site

    /content/journals/cpr/10.2174/0115733963321945241118113026
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Doğan S. Kebudi R. Evren İ. Darendeliler E. Blut M. Ayan İ. Çocukluk Çağında Primer Renal Ganglionöroblastom Vakası. Türk Onkoloji Dergisi. 1995 10 3 56 58
    [Google Scholar]
  2. Brodeur G.M. Seeger R.C. Barrett A. Berthold F. Castleberry R.P. D’Angio G. De Bernardi B. Evans A.E. Favrot M. Freeman A.I. International criteria for diagnosis, staging, and response to treatment in patients with neuroblastoma. J. Clin. Oncol. 1988 6 12 1874 1881 10.1200/JCO.1988.6.12.1874 3199170
    [Google Scholar]
  3. Brodeur G.M. Pritchard J. Berthold F. Carlsen N.L. Castel V. Castelberry R.P. De Bernardi B. Evans A.E. Favrot M. Hedborg F. Revisions of the international criteria for neuroblastoma diagnosis, staging, and response to treatment. J. Clin. Oncol. 1993 11 8 1466 1477 10.1200/JCO.1993.11.8.1466 8336186
    [Google Scholar]
  4. Monclair T. Brodeur G.M. Ambros P.F. Brisse H.J. Cecchetto G. Holmes K. Kaneko M. London W.B. Matthay K.K. Nuchtern J.G. von Schweinitz D. Simon T. Cohn S.L. Pearson A.D.J. The International Neuroblastoma Risk Group (INRG) Staging System: An INRG Task Force Report. J. Clin. Oncol. 2009 27 2 298 303 10.1200/JCO.2008.16.6876 19047290
    [Google Scholar]
  5. Cohn S.L. Pearson A.D.J. London W.B. Monclair T. Ambros P.F. Brodeur G.M. Faldum A. Hero B. Iehara T. Machin D. Mosseri V. Simon T. Garaventa A. Castel V. Matthay K.K. The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report. J. Clin. Oncol. 2009 27 2 289 297 10.1200/JCO.2008.16.6785 19047291
    [Google Scholar]
  6. Pinto N.R. Applebaum M.A. Volchenboum S.L. Matthay K.K. London W.B. Ambros P.F. Nakagawara A. Berthold F. Schleiermacher G. Park J.R. Valteau-Couanet D. Pearson A.D.J. Cohn S.L. Advances in Risk Classification and Treatment Strategies for Neuroblastoma. J. Clin. Oncol. 2015 33 27 3008 3017 10.1200/JCO.2014.59.4648 26304901
    [Google Scholar]
  7. Olgun N. Aksoylar S. Varan A. Vergin C. Hazar V. Akici F. Dagdemir A. Buyukavci M. Kebudi R. Kurucu N. Sevinir B. Unal E. Vural S. Guler E. Apak H. Oniz H. Karadeniz C. Canpolat C. Anak S. Ilhan I. Ince D. Cecen E. Treatment of high-risk neuroblastoma: National protocol results of the Turkish Pediatric Oncology Group. J. Cancer Res. Ther. 2017 13 2 284 290 10.4103/0973‑1482.183205 28643749
    [Google Scholar]
  8. Türk Pediatrik Onkoloji Grubu Nöroblastom-2020 Protokolü. Available from:https://tpog.org.tr/tpog-noroblastom-2020-protokolu/(accessed on 28-9-2024)
  9. Kebudi R. Alkaya D.U. Epidemiology and survival of childhood cancer in Turkey. Pediatr. Blood Cancer 2021 68 2 e28754 10.1002/pbc.28754 33034155
    [Google Scholar]
  10. Chung C. Boterberg T. Lucas J. Neuroblastoma. Pediatr. Blood Cancer. 2021 68 S2 e28473 10.1002/pbc.28473
    [Google Scholar]
  11. Henderson T.O. Bhatia S. Pinto N. London W.B. McGrady P. Crotty C. Sun C.L. Cohn S.L. Racial and ethnic disparities in risk and survival in children with neuroblastoma: a Children’s Oncology Group study. J. Clin. Oncol. 2011 29 1 76 82 10.1200/JCO.2010.29.6103 21098321
    [Google Scholar]
  12. Ünal E. Yilmaz E. Özcan A. Twenty children with non-Wilms renal tumors from a reference center in Central Anatolia, Turkey. Turk. J. Med. Sci. 2020 50 1 18 24 10.3906/sag‑1902‑106
    [Google Scholar]
  13. Malkan A.D. Loh A. Bahrami A. Navid F. Coleman J. Green D.M. Davidoff A.M. Sandoval J.A. An approach to renal masses in pediatrics. Pediatrics 2015 135 1 142 158 10.1542/peds.2014‑1011 25452658
    [Google Scholar]
  14. Ferraro S. Braga F. Luksch R. Terenziani M. Caruso S. Panteghini M. Measurement of Serum Neuron-Specific Enolase in Neuroblastoma: Is There a Clinical Role? Clin. Chem. 2020 66 5 667 675 10.1093/clinchem/hvaa073 32353141
    [Google Scholar]
  15. Kogut M.D. Donnell G.N. Cushing’s syndrome in association with renal ganglioneuroblastoma. Pediatrics 1961 28 4 566 577 10.1542/peds.28.4.566 14457797
    [Google Scholar]
  16. Shende A. Wind E.S. Lanzkowsky P. Intrarenal neuroblastoma mimicking Wilms’ tumor. N. Y. State J. Med. 1979 79 1 93 215945
    [Google Scholar]
  17. Rosenfield N.S. Leonidas J.C. Barwick K.W. Aggressive neuroblastoma simulating Wilms tumor. Radiology 1988 166 1 165 167 10.1148/radiology.166.1.2827230 2827230
    [Google Scholar]
  18. Verma L. Sandramouli S. Garg S.P. Vashisht S. Intrarenal neuroblastoma presenting as orbital and multiple skeletal metastases. Indian Pediatr. 1993 30 5 673 676 8282398
    [Google Scholar]
  19. Kessler O.J. Siegel J.F. Brock W.A. Intrarenal neuroblastoma masquerading as wilms’ tumor. Urology 1998 51 2 313 316 10.1016/S0090‑4295(97)00690‑0 9495717
    [Google Scholar]
  20. Gupta D.K. Lall A. Bajpai M. Intrarenal neuroblastoma - a diagnostic dilemma: A report of three cases. Indian J. Urol. 2001 17 2 170 172 10.4103/0970‑1591.20265
    [Google Scholar]
  21. Serrano R. Rodríguez-Peralto J.L. De Orbe G.G. Melero C. de Agustín P. Intrarenal neuroblastoma diagnosed by fine-needle aspiration: A report of two cases. Diagn. Cytopathol. 2002 27 5 294 297 10.1002/dc.10184 12411996
    [Google Scholar]
  22. Sarin Y.K. Sinha A. Sengar M. Intrarenal neuroblastoma: a case report. J. Indian Assoc. Pediatr. Surg. 2002 7 2 76 79
    [Google Scholar]
  23. Sellaturay S.V. Arya M. Banisadr S. Murthi G.V. Sebire N.J. Duffy P.G. Primary intrarenal neuroblastoma: A rare, aggressive tumour of childhood mimicking Wilms’ tumour. J. Pediatr. Urol. 2006 2 5 522 524 10.1016/j.jpurol.2005.11.010 18947673
    [Google Scholar]
  24. Dickson P.V. Sims T.L. Streck C.J. McCarville M.B. Santana V.M. McGregor L.M. Furman W.L. Davidoff A.M. Avoiding misdiagnosing neuroblastoma as Wilms tumor. J. Pediatr. Surg. 2008 43 6 1159 1163 10.1016/j.jpedsurg.2008.02.047 18558200
    [Google Scholar]
  25. Fan R. Primary renal neuroblastoma--a clinical pathologic study of 8 cases. Am. J. Surg. Pathol. 2012 36 1 94 100 10.1097/PAS.0b013e318233083b 21989352
    [Google Scholar]
  26. Garnier S. Maillet O. Haouy S. Saguintaah M. Serre I. Galifer R.B. Forgues D. Guibal M.P. Allal H. Sabatier E. Kalfa N. Prenatal intrarenal neuroblastoma mimicking a mesoblastic nephroma: a case report. J. Pediatr. Surg. 2012 47 8 e21 e23 10.1016/j.jpedsurg.2012.03.090 22901938
    [Google Scholar]
  27. Shamsian B.S. Kajizadi M. Rezaei N. Ghojehvand N. Azma R. Rouzrokh M. Kazemi Aghdam M. Mesbah S.M. Ghazizadeh F. Arzanian M.T. Primary intrarenal neuroblastoma with hypertension and disseminated intravascular coagulation. Case Rep. Oncol. Med. 2013 2013 1 4 10.1155/2013/684939 24416605
    [Google Scholar]
  28. Treetipsatit J. Pradniwat K. Laohapensang M. Rongviriyapanich C. Phuakpet K. Sanpakit K. Primary intrarenal/perirenal neuroblastoma mimicking Wilms’ tumor at presentation in a 5-year-old girl: a case report from Siriraj hospital. J. Med. Assoc. Thai. 2014 97 9 982 987 25536717
    [Google Scholar]
  29. Bauchinger S. Lackner H. Schwinger W. Sovinz P. Benesch M. Sorantin E. Till H. Urban C. Primary renal neuroblastoma metastasizing into liver and lungs with tumor thrombus extension into the right atrium. Klin. Padiatr. 2014 226 06/07 369 371 10.1055/s‑0034‑1375654 25062108
    [Google Scholar]
  30. Farmakis S.G. Siegel M.J. Intrarenal neuroblastoma with pulmonary metastases mimicking a Wilms tumor. J. Pediatr. Surg. 2014 49 12 1864 1866 10.1016/j.jpedsurg.2014.10.043 25487502
    [Google Scholar]
  31. Faizan M. Sultana N. Anwar S. Mehmood Q. Ali A.S. Intrarenal neuroblastoma: a diagnostic challenge. J. Coll. Physicians Surg. Pak. 2015 25 Suppl. 1 S41 S42 25933461
    [Google Scholar]
  32. Zenitani M. Uehara S. Miyashita E. Hashii Y. Oue T. Okuyama H. Primary renal neuroblastoma with metastasis and matrix metalloproteinase-14 expression. Pediatr. Int. 2016 58 2 161 164 10.1111/ped.12751 26541120
    [Google Scholar]
  33. Telli O. Ateş U. Ergun E. Yıldız R.V. Yağmurlu B. Yalçın B. Bilezikçi B. Göllü G. Yağmurlu A. Primary intrarenal neuroblastoma in a 13-month-old girl presenting as a Wilms’ tumor with pulmonary metastasis. Turk. J. Pediatr. 2016 58 5 532 534 10.24953/turkjped.2016.05.011 28621095
    [Google Scholar]
  34. Tang P.M.Y. Leung M.W.Y. Chao N.S.Y. Primary Intra-Renal Neuroblastoma – A Diagnostic Dilemma: A Case Report. HK J Pediatr 2016 21 39 42 [new series].
    [Google Scholar]
  35. Solmuthu Azhagan S. Srinivasan A. Rajendran S. Ravinder D. Yadav R. Ramachandran P. Vij M. Xavier Scott J. A Rare Case of Perinatal Intrarenal Neuroblastoma. J. Pediatr. Hematol. Oncol. 2017 39 4 e216 e218 10.1097/MPH.0000000000000775 28085745
    [Google Scholar]
  36. Moscheo C. Campari A. Podda M.G. Riccipetitoni G. Collini P. Renne S.L. Vella C. Napolitano M. Luksch R. Peripheral neuroblastic tumor of the kidney: case report and review of literature. Tumori 2018 104 6 NP34 NP37 10.1177/0300891618788475 30021475
    [Google Scholar]
  37. Hu J. Wang H. Primary renal ganglioneuroblastoma mimicking Wilms’ tumor in a 3-year-old girl. Pediatr. Int. 2021 63 1 106 107 10.1111/ped.14365 33421229
    [Google Scholar]
  38. Akçaer V. Eren T. Taştekin E. Primary renal neuroblastoma mimicking Wilms’ tumor. Balkan Med. J. 2020 38 2 135 136 10.4274/balkanmedj.galenos.2020.2020.7.204 33233872
    [Google Scholar]
  39. Kaur K. Meena J.P. Sri P. Gupta A.K. Jana M. Iyer V.K. Kumar R. Seth R. Primary renal neuroblastoma mimicking wilms tumor. Indian J. Med. Paediatr. Oncol. 2021 42 4 380 384 10.1055/s‑0041‑1735438
    [Google Scholar]
  40. Jiang M. Hu X. Qian K. Yang P. Tang Y. Wang P. Cai J. Atypical CT findings of renal neuroblastoma: a case report. Transl. Pediatr. 2022 11 7 1267 1273 10.21037/tp‑22‑205 35958006
    [Google Scholar]
  41. Al Taei T.H. Asrar alzaher Al Mail S.A. Primary Intrarenal neuroblastoma in a 5-month-Old infant: A diagnostic dilemma. J. Pediatr. Surg. Case Rep. 2022 80 102246 10.1016/j.epsc.2022.102246
    [Google Scholar]
  42. Kaushik A. Sherwani P. Saurya Garnaik D.K. Diagnostic dilemma in left flank mass in an infant: A rare case of intrarenal neuroblastoma. Afr. J. Paediatr. Surg. 2023 20 2 152 154 10.4103/ajps.ajps_124_21 36960513
    [Google Scholar]
  43. Tokmak H. Kebudi R. Gümüş T. Demirkol O. Pulmonary metastasis in neuroblastoma at initial diagnosis. J. Pediatr. Hematol. Oncol. 2012 34 7 581 582 10.1097/MPH.0b013e318269bbb9 23007343
    [Google Scholar]
  44. Miniati D. Gay A.N. Parks K.V. Naik-Mathuria B.J. Hicks J. Nuchtern J.G. Cass D.L. Olutoye O.O. Imaging accuracy and incidence of Wilms’ and non-Wilms’ renal tumors in children. J. Pediatr. Surg. 2008 43 7 1301 1307 10.1016/j.jpedsurg.2008.02.077 18639686
    [Google Scholar]
  45. Dumba M. Jawad N. McHugh K. Neuroblastoma and nephroblastoma: a radiological review. Cancer Imag. 2015 15 1 5 10.1186/s40644‑015‑0040‑6
    [Google Scholar]
  46. Sharp S.E. Trout A.T. Weiss B.D. Gelfand M.J. MIBG in neuroblastoma diagnostic imaging and therapy. Radiographics 2016 36 1 258 278 10.1148/rg.2016150099 26761540
    [Google Scholar]
  47. Wang J. Li M. Tang D. Gu W. Mao J. Shu Q. Current treatment for Wilms tumor: COG and SIOP standards. World J. Pediatr. Surg. 2019 2 3 e000038 10.1136/wjps‑2019‑000038
    [Google Scholar]
  48. von Allmen D. Davidoff A.M. London W.B. Van Ryn C. Haas-Kogan D.A. Kreissman S.G. Khanna G. Rosen N. Park J.R. La Quaglia M.P. Impact of extent of resection on local control and survival in patients from the cog a3973 study with high-risk neuroblastoma. J. Clin. Oncol. 2017 35 2 208 216 10.1200/JCO.2016.67.2642 27870572
    [Google Scholar]
  49. Qi Y. Zhan J. Roles of surgery in the treatment of patients with high-risk neuroblastoma in the Children Oncology Group Study: A systematic review and meta-analysis. Front Pediatr. 2021 9 706800 10.3389/fped.2021.706800 34722415
    [Google Scholar]
  50. Irwin M.S. Naranjo A. Zhang F.F. Cohn S.L. London W.B. Gastier-Foster J.M. Ramirez N.C. Pfau R. Reshmi S. Wagner E. Nuchtern J. Asgharzadeh S. Shimada H. Maris J.M. Bagatell R. Park J.R. Hogarty M.D. Revised neuroblastoma risk classification system: A report from the children’s oncology group. J. Clin. Oncol. 2021 39 29 3229 3241 10.1200/JCO.21.00278 34319759
    [Google Scholar]
  51. Schneiderman J. London W.B. Brodeur G.M. Castleberry R.P. Look A.T. Cohn S.L. Clinical significance of MYCN amplification and ploidy in favorable-stage neuroblastoma: A report from the Children’s Oncology Group. J. Clin. Oncol. 2008 26 6 913 918 10.1200/JCO.2007.13.9493 18281664
    [Google Scholar]
  52. van den Heuvel-Eibrink M.M. Hol J.A. Pritchard-Jones K. van Tinteren H. Furtwängler R. Verschuur A.C. Vujanic G.M. Leuschner I. Brok J. Rübe C. Smets A.M. Janssens G.O. Godzinski J. Ramírez-Villar G.L. de Camargo B. Segers H. Collini P. Gessler M. Bergeron C. Spreafico F. Graf N. Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP–RTSG 2016 protocol. Nat. Rev. Urol. 2017 14 12 743 752 10.1038/nrurol.2017.163 29089605
    [Google Scholar]
  53. Vujanić G.M. Gessler M. Ooms A.H.A.G. Collini P. Coulomb-l’Hermine A. D’Hooghe E. de Krijger R.R. Perotti D. Pritchard-Jones K. Vokuhl C. van den Heuvel-Eibrink M.M. Graf N. The UMBRELLA SIOP–RTSG 2016 Wilms tumour pathology and molecular biology protocol. Nat. Rev. Urol. 2018 15 11 693 701 10.1038/s41585‑018‑0100‑3 30310143
    [Google Scholar]
  54. Vujanić G.M. Kelsey A. Mitchell C. Shannon R.S. Gornall P. The role of biopsy in the diagnosis of renal tumors of childhood: Results of the UKCCSG Wilms tumor study 3. Med. Pediatr. Oncol. 2003 40 1 18 22 10.1002/mpo.10216 12426681
    [Google Scholar]
  55. Strother D.R. London W.B. Schmidt M.L. Brodeur G.M. Shimada H. Thorner P. Collins M.H. Tagge E. Adkins S. Reynolds C.P. Murray K. Lavey R.S. Matthay K.K. Castleberry R. Maris J.M. Cohn S.L. Outcome after surgery alone or with restricted use of chemotherapy for patients with low-risk neuroblastoma: results of Children’s Oncology Group study P9641. J. Clin. Oncol. 2012 30 15 1842 1848 10.1200/JCO.2011.37.9990 22529259
    [Google Scholar]
/content/journals/cpr/10.2174/0115733963321945241118113026
Loading
Primary Renal Neuroblastoma: A Case Report and Review of the Literature
Bentham Science Publishers ; https://doi.org/10.2174/0115733963321945241118113026
/content/journals/cpr/10.2174/0115733963321945241118113026
/content/journals/cpr/10.2174/0115733963321945241118113026
Loading

Data & Media loading...


  • Article Type:     Case Report
Keywords: İntrarenal neuroblastoma ; non-wilms renal tumors ; renal tumor ; renal neuroblastoma ; renal ganglioneuroblastoma ; intrarenal ganglioneuroblastoma

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test