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2000
Volume 21, Issue 3
  • ISSN: 1573-3963
  • E-ISSN: 1875-6336
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Abstract

This perspective reviews the definition and current understanding of necrotizing enterocolitis and evaluates a future prevention approach to this multifactorial disease. An overview of the prevention approach in general is presented, where key aspects and emerging criticisms are identified. In addition, key elements of early diagnosis and treatment are presented, together with some of their challenges and ambiguities. Moreover, it concludes with emerging questions from the global community to reach a consensus on the definition, diagnosis, and management of necrotizing enterocolitis disease.

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2024-09-26
2025-10-27

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References

  1. NeuJ. WalkerW.A. Necrotizing Enterocolitis.N. Engl. J. Med.2011364325526410.1056/NEJMra100540821247316
     [Google Scholar]
  2. De BernardoG. Necrotizing Enterocolitis: From Diagnosis to Therapy.Curr. Pediatr. Rev.20191526710.2174/15733963150219072209175431433747
     [Google Scholar]
  3. HackamD.J. SodhiC.P. Bench to bedside — New insights into the pathogenesis of necrotizing enterocolitis.Nat. Rev. Gastroenterol. Hepatol.202219746847910.1038/s41575‑022‑00594‑x35347256
     [Google Scholar]
  4. RoseA.T. PatelR.M. A critical analysis of risk factors for necrotizing enterocolitis.Semin. Fetal Neonatal Med.201823637437910.1016/j.siny.2018.07.00530115546
     [Google Scholar]
  5. CunaA. GeorgeL. SampathV. Genetic predisposition to necrotizing enterocolitis in premature infants: Current knowledge, challenges, and future directions.Semin Fetal Neonatal Med201823638739310.1016/j.siny.2018.08.006
     [Google Scholar]
  6. NeuJ. Prevention of Necrotizing Enterocolitis.Clin Perinatol202249119520610.1016/j.clp.2021.11.012
     [Google Scholar]
  7. PatelR.M. FergusonJ. McElroyS.J. KhashuM. CaplanM.S. Defining necrotizing enterocolitis: Current difficulties and future opportunities.Pediatr. Res.202088S1101510.1038/s41390‑020‑1074‑432855506
     [Google Scholar]
  8. HuX. LiangH. LiF. ZhangR. ZhuY. ZhuX. XuY. Necrotizing enterocolitis: current understanding of the prevention and management.Pediatr. Surg. Int.20244013210.1007/s00383‑023‑05619‑338196049
     [Google Scholar]
  9. CunaA. MorowitzM.J. SampathV. Early antibiotics and risk for necrotizing enterocolitis in premature infants: A narrative review.Front Pediatr.202311111281210.3389/fped.2023.111281236865691
     [Google Scholar]
  10. De BernardoG. SordinoD. De ChiaraC. RiccitelliM. EspositoF. GiordanoM. TramontanoA. Management of NEC: Surgical Treatment and Role of Traditional X-ray versus Ultrasound Imaging, Experience of a Single Centre.Curr. Pediatr. Rev.201915212513010.2174/157339631466618110212262630387397
     [Google Scholar]
  11. ShelbyR.D. RaabR. BesnerG.E. McElroyS.J. Hope on the horizon: Promising novel therapies for necrotizing enterocolitis.Pediatr. Res.202088S1303410.1038/s41390‑020‑1077‑132855510
     [Google Scholar]
  12. PerroneS. LaschiE. De BernardoG. GiordanoM. VanacoreF. TassiniM. CalderisiM. ToniA.L. BuonocoreG. LonginiM. Newborn metabolomic profile mirrors that of mother in pregnancy.Med. Hypotheses202013710954310.1016/j.mehy.2019.10954331901880
     [Google Scholar]
  13. BazacliuC. NeuJ. Pathophysiology of Necrotizing Enterocolitis: An Update.Curr. Pediatr. Rev.2019152688710.2174/157339631466618110212303030387398
     [Google Scholar]
  14. ShenR. EmbletonN. Lyng FormanJ. GaleC. GreisenG. SangildP.T. UthayaS. BerringtonJ. Early antibiotic use and incidence of necrotising enterocolitis in very preterm infants: A protocol for a UK based observational study using routinely recorded data.BMJ Open20221211e06593410.1136/bmjopen‑2022‑06593436379645
     [Google Scholar]
  15. KlerkD.H. van AvezaathL.K. LoeffenE.A.H. HulscherJ.B.F. KooiE.M.W. Fetal–neonatal exposure to antibiotics and NEC development: A systematic review and meta-analysis.Front Pediatr.202310110288410.3389/fped.2022.110288436727006
     [Google Scholar]
  16. De BernardoG. D’UrsoG. SpadarellaS. GiordanoM. LeoneG. CasapulloA. Analysis of the Fecal Metabolomic Profile in Breast vs. Different Formula Milk Feeding in Late Preterm Infants.Metabolites20241417210.3390/metabo1401007238276307
     [Google Scholar]
  17. ZhuK. GaoH. YuanL. WangL. DengF. Prolonged antibiotic therapy increased necrotizing enterocolitis in very low birth weight infants without culture-proven sepsis.Front Pediatr.20221094983010.3389/fped.2022.94983036147802
     [Google Scholar]
  18. TewariV.V. DubeyS.K. KumarR. VardhanS. SreedharC.M. GuptaG. Early versus Late Enteral Feeding in Preterm Intrauterine Growth Restricted Neonates with Antenatal Doppler Abnormalities: An Open-Label Randomized Trial.J. Trop. Pediatr.201864141410.1093/tropej/fmx01828369652
     [Google Scholar]
  19. ProiettiF. De BernardoG. LonginiM. SordinoD. ScaramuzziniG. TatarannoM.L. BelvisiE. BazziniF. PerroneS. BuonocoreG. Neonatal oxidative stress depends on oxygen blood pressure in umbilical artery.J. Biol. Regul. Homeost. Agents201630392993427655523
     [Google Scholar]
  20. KaplinaA. KononovaS. ZaikovaE. PervuninaT. PetrovaN. SitkinS. Necrotizing Enterocolitis: The Role of Hypoxia, Gut Microbiome, and Microbial Metabolites.Int. J. Mol. Sci.2023243247110.3390/ijms2403247136768793
     [Google Scholar]
  21. SongJ. DongH. XuF. WangY. LiW. JueZ. WeiL. YueY. ZhuC. The association of severe anemia, red blood cell transfusion and necrotizing enterocolitis in neonates.PLoS One2021167e025481010.1371/journal.pone.025481034283868
     [Google Scholar]
  22. KalterenW.S. BosA.F. van OeverenW. HulscherJ.B.F. KooiE.M.W. Neonatal anemia relates to intestinal injury in preterm infants.Pediatr. Res.20229161452145810.1038/s41390‑021‑01903‑x34907357
     [Google Scholar]
  23. IijimaS. Clinical Dilemma Involving Treatments for Very Low-Birth-Weight Infants and the Potential Risk of Necrotizing Enterocolitis: A Narrative Literature Review.J. Clin. Med.20231316210.3390/jcm1301006238202069
     [Google Scholar]
  24. PerroneS. LaschiE. BuonocoreG. Biomarkers of oxidative stress in the fetus and in the newborn.Free Radic. Biol. Med.2019142233110.1016/j.freeradbiomed.2019.03.03430954545
     [Google Scholar]
  25. AydemirC. DilliD. UrasN. UluH.O. OguzS.S. ErdeveO. DilmenU. Total oxidant status and oxidative stress are increased in infants with necrotizing enterocolitis.J. Pediatr. Surg.201146112096210010.1016/j.jpedsurg.2011.06.03222075338
     [Google Scholar]
  26. PerroneS. TatarannoM.L. NegroS. CornacchioneS. LonginiM. ProiettiF. SoubasiV. BendersM.J. Van BelF. BuonocoreG. May oxidative stress biomarkers in cord blood predict the occurrence of necrotizing enterocolitis in preterm infants?J. Matern. Fetal Neonatal Med.201225sup112813110.3109/14767058.2012.66319722339378
     [Google Scholar]
  27. BethellGS. HallNJ. Recent advances in our understanding of NEC diagnosis, prognosis and surgical approach.Front Pediatr202311122985010.3389/fped.2023.1229850
     [Google Scholar]
  28. PatelR.M. UnderwoodM.A. Probiotics and necrotizing enterocolitis.Semin. Pediatr. Surg.2018271394610.1053/j.sempedsurg.2017.11.00829275816
     [Google Scholar]
  29. UnderwoodM.A. Impact of probiotics on necrotizing enterocolitis.Semin. Perinatol.2017411415110.1053/j.semperi.2016.09.01727836423
     [Google Scholar]
  30. SzajewskaH. Berni CananiR. DomellöfM. GuarinoA. HojsakI. IndrioF. Lo VecchioA. MihatschW.A. MoscaA. OrelR. SalvatoreS. ShamirR. van den AkkerC.H.P. van GoudoeverJ.B. VandenplasY. WeizmanZ. Probiotics for the Management of Pediatric Gastrointestinal Disorders: Position Paper of the ESPGHAN Special Interest Group on Gut Microbiota and Modifications.J. Pediatr. Gastroenterol. Nutr.202376223224710.1097/MPG.000000000000363336219218
     [Google Scholar]
  31. ZozayaC. GanjiN. LiB. Janssen LokM. LeeC. KoikeY. GaudaE. OffringaM. EatonS. ShahP.S. PierroA. Remote ischaemic conditioning in necrotising enterocolitis: A phase I feasibility and safety study.Arch. Dis. Child. Fetal Neonatal Ed.20231081697610.1136/archdischild‑2022‑32417435940871
     [Google Scholar]
  32. RamaniM. AmbalavananN. Feeding practices and necrotizing enterocolitis.Clin. Perinatol.201340111010.1016/j.clp.2012.12.00123415260
     [Google Scholar]
  33. AltobelliE. AngelettiP.M. VerrottiA. PetrocelliR. The Impact of Human Milk on Necrotizing Enterocolitis: A Systematic Review and Meta-Analysis.Nutrients2020125132210.3390/nu1205132232384652
     [Google Scholar]
  34. PaganoF. GaetaE. MorlinoF. RiccioMT. GiordanoM. De BernardoG. Long-term benefits of exclusive human milk diet in small for gestational age neonates: A systematic review of the literature.Ital J Pediatr20245018810.1186/s13052‑024‑01648‑3
     [Google Scholar]
  35. LemboC. BuonocoreG. PerroneS. Oxidative Stress in Preterm Newborns.Antioxidants20211011167210.3390/antiox1011167234829543
     [Google Scholar]
  36. PerroneS. GiordanoM. De BernardoG. LuganiP. SarnacchiaroP. StazzoniG. BuonocoreG. EspositoS. TatarannoML. Management of oxygen saturation monitoring in preterm newborns in the NICU: The Italian picture.Ital J Pediatr202147110410.1186/s13052‑021‑01050‑3
     [Google Scholar]
  37. CanvasserJ. PatelR.M. PryorE. GreenL. HintzS.R. FaganM. HarrisonJ.D. Long-term outcomes and life-impacts of necrotizing enterocolitis: A survey of survivors and parents.Semin. Perinatol.202347115169610.1016/j.semperi.2022.15169636631356
     [Google Scholar]
/content/journals/cpr/10.2174/0115733963318619240923062033
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Necrotizing Enterocolitis: A Current Understanding and Challenges for the Future
Curr Pediatr Rev 21, 207 (2025); https://doi.org/10.2174/0115733963318619240923062033
/content/journals/cpr/10.2174/0115733963318619240923062033
/content/journals/cpr/10.2174/0115733963318619240923062033
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  • Article Type:     Editorial
Keyword(s): antibiotics; dysbiosis; genetic predisposition; low body weight; metabolites; mother; Preterm newborns; ultrasound

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