Current Pharmaceutical Analysis - Volume 14, Issue 3, 2018

Background: Letrozole (LTZ) is a potent aromatase inhibitor which blocks estrogen synthesis in post-menopausal women. Suitable analytical methods are required to quantify letrozole in bulk and its nanoformulations. Hence a sensitive and robust reverse-phase high performance liquid chromatographic method (RP-HPLC) was developed for the estimation of LTZ. Methods: The method was developed using Kinetex C18 c Read More

Background: It is still uncertain whether the accumulation of the bile acids (BAs) in hepatocytes beyond the normal stand after taking medicine which can cause hepatic injury or under the pathological state. Because it is lack of valid and simple analytical methods for the quantification of individual BAs and their taurine and glycine conjugates in the hepatocytes. It is necessary to develop methods for BAs quantification in h Read More