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Since the global spread of covid-19, PCR predominantly has taken the lead in the diagnosis. It amplifies a particular DNA target sequence into millions of copies. To simplify the laboratory- dependent disease diagnosis, the point of care diagnostics (POC) paved the way for labon- a-chip-technology. Succeeding that, POC integrated with PCR stole the limelight. This review points out the various diagnostic methods of covid-19 based on PCR and POC-PCR along with its principles, and types clustered regularly interspaced short palindromic repeats (CRISPR) based assays for the rapid, accurate, and easier detection of covid-19.