Synthesis and Biological Screening of N,N'-bis Disubstituted Adipic Acid Thioureas

Background: Synthesis of substituted N'-aryl-N'-adipic acid thiourea (1-7) was, carried out adipic acid chlorides with potassium thiocynate in situ produced isocyanate followed by reflux with substituted anilines in dry acetone till the completion of reaction. Methods: Structure elucidation of all the synthesized compounds was carried out by UV-Vis, FT-IR and 1HNMR analysis. All the synthesized compounds were evaluated for their biological screening by subjecting to antimicrobial and antioxidant activities. Conclusion: In case of antibacterial screening most significant results were obtained by compound 7 having fluoro group at the para position with 16.5±1.0 zone of inhibition against methicilline resistant S. aureus (MRSA 09) while no activity was observed in case of antifungal activities. Compound 7 also showed significant antioxidant activities in DPPH assay with percent scavenging values of 63.51±.8.3.