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2000
Volume 6, Issue 4
  • ISSN: 2666-7967
  • E-ISSN: 2666-7975

Abstract

Till now, 642 million COVID-19 cases have been confirmed, claiming around 6.62 million lives. The impact of SARS-CoV-2 on the male reproductive system, both short and long-term, remains a mystery. This study aims to scrutinize how SARS-CoV-2 affects sexual function, considering potential mediators such as psychological stress. Results reveal that the infection intensifies metabolic stress, directly or indirectly impacting male fertility and causing psychological distress with heightened ROS generation. The exclusive presence of Angiotensin-converting enzyme 2 (ACE2) in type II pneumocytes, serving as the virus receptor, suggests lungs as the primary target. In conclusion, SARS-CoV-2 infection potentially diminishes male fertility, primarily due to psychological stress, raising concerns about COVID-19-induced male infertility amid other factors. Despite limited therapeutic options for COVID-19 and ongoing vaccine efforts, the persistent threat of diverse strains poses a long-term risk to global population health.

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2024-07-29
2025-10-03

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/content/journals/covid/10.2174/0126667975316497240725102111
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Prolonged COVID-19's Double Impact: Stress and Male Fertility
Coronaviruses 6, E290724232390 (2025); https://doi.org/10.2174/0126667975316497240725102111
/content/journals/covid/10.2174/0126667975316497240725102111
/content/journals/covid/10.2174/0126667975316497240725102111
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  • Article Type:     Review Article
Keyword(s): ACE-2; Long term COVID-19; male infertility; psychological stress; ROS generation; type II pneumocytes

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