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2000
Volume 6, Issue 1
  • ISSN: 2666-7967
  • E-ISSN: 2666-7975

Abstract

Objective

Ferroptosis is a form of programmed cell death characterized by the iron-dependent accumulation of lipid peroxides, leading to membrane damage and cell rupture. Several lines of evidence suggest that ferroptosis may contribute to the pathogenesis and severity of COVID-19. This study aimed to measure iron metabolism and lipid peroxidation markers in COVID-19 patients to establish a direct link between ferroptosis and COVID-19.

Methods

In the present cross-sectional study, the serum levels of hemoglobin (Hb), ferritin, and iron, total iron binding capacity (TIBC), malondialdehyde (MDA), and glutathione (GSH) were assessed in 100 COVID-19 patients diagnosed using Real-time PCR and compared to the levels in 100 healthy individuals.

Results

Our findings revealed a significant increase in serum levels of ferritin and MDA in COVID-19 patients compared to control subjects. Conversely, TIBC, Hb, Iron, and GSH levels were lower in COVID-19 patients than in control.

Conclusion

Our study provides further evidence supporting the significance of ferroptosis in the pathogenesis of COVID-19. Further research aimed at elucidating the exact role of ferroptosis in COVID-19 is warranted, as it may lead to improved strategies for mitigating multi-organ dysfunction associated with this disease.

© 2025 Bentham Science Publishers
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2024-02-01
2025-09-07

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/content/journals/covid/10.2174/0126667975288661240123075201
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Role of Ferroptosis in COVID-19 Pathogenesis: Insights from Iron Metabolism and Lipid Peroxidation Markers
Coronaviruses 6, E010224226642 (2025); https://doi.org/10.2174/0126667975288661240123075201
/content/journals/covid/10.2174/0126667975288661240123075201
/content/journals/covid/10.2174/0126667975288661240123075201
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  • Article Type:     Research Article
Keyword(s): COVID-19; Ferroptosis; glutathione; hemoglobin; malondialdehyde; stress oxidative

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