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2000
Volume 4, Issue 1
  • ISSN: 2666-7797
  • E-ISSN: 2666-7800

Abstract

Introduction

Acne vulgaris is a common chronic inflammatory disorder affecting the pilosebaceous unit, which leads to the development of inflammatory lesions such as papules, pustules, nodules, cysts, and non-inflammatory comedones. While it typically begins during adolescence, it can also occur in individuals in their 20s or 30s.

Methods

A comprehensive literature review was conducted using the Web of Science, PubMed, and other scholarly repositories spanning from 2001 to 2024. Articles were chosen based on their exploration of Acne vulgaris's effects on the skin and its treatment approaches, including conventional methods and nanotechnology. Keywords such as “Acne vulgaris, Nanotechnology, Nanoparticles, Retinoids, and Antibiotics” were utilized for selection. Studies that were not in English or lacked sufficient detail on Acne vulgaris were excluded based on predefined criteria. Conventional acne treatments, such as benzoyl peroxide, acids, retinoids, and antibiotics, are frequently used. However, these treatments face significant challenges, including toxicity, poor water solubility, limited retention time at the target site, and inadequate penetration through the skin's outer layer (stratum corneum). In response to these limitations, recent pharmaceutical advancements are focusing on developing nanoparticle-based drug delivery systems to improve the effectiveness of acne treatments.

Results and Discussion

Nanoparticles provide multiple advantages in treating acne. They improve skin hydration, enhance drug penetration, prolong retention at the target site, increase drug solubility, and enable sustained release of the medication. These improvements are attributed to the nanoparticles' small size, lipid occlusion properties, and specialized surface characteristics.

Conclusion

Nanoparticle-based drug delivery systems offer promising solutions for overcoming the limitations of traditional acne treatments. By improving drug delivery and therapeutic efficacy, they reduce the need for frequent dosing and present a more effective and targeted approach to managing acne vulgaris.

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/content/journals/cosci/10.2174/0126667797362809250421114627
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A Comprehensive Overview of Nanoparticles in Acne Management: Current Trends and Future Prospects
Curr. Cosm. Sci. 4, E26667797362809 (2025); https://doi.org/10.2174/0126667797362809250421114627
/content/journals/cosci/10.2174/0126667797362809250421114627
/content/journals/cosci/10.2174/0126667797362809250421114627
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  • Article Type:     Review Article
Keyword(s): Acne vulgaris; antibiotics; lipid occlusion properties; nanoparticles; nanotechnology; retinoids

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