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2000
Volume 20, Issue 4
  • ISSN: 1570-1794
  • E-ISSN: 1875-6271

Abstract

Objective: Misoprostol is a synthetic prostaglandin that is related structurally to naturally occurring prostaglandin (PG), and it has been acknowledged as an effective inhibitor of gastric acid secretion when administered intravenously. Methods: In the present study, the novel application of 1,8-Diazabicyclo[5.4.0]undec-7-ene, a cyclic unsaturated amine [DBU] for the conversion of A-type Misoprostol (A-MP) to B-type Misoprostol (B-MP) via intramolecular isomerization. Results: The intramolecular isomerization process was successfully applied for the separation of enantio-pure isomers with no impurities using DBU. Conclusion: The chemical structures of A-MP and B-MP were confirmed using spectral analyses of 1H-NMR, 13C-NMR and Mass spectroscopy.

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/content/journals/cos/10.2174/1570179419666220831100708
2023-06-01
2024-11-12
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/content/journals/cos/10.2174/1570179419666220831100708
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  • Article Type:
    Research Article
Keyword(s): DBU; inhibitor; intra molecular; isomerization; Misoprostol; prostaglandin
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