An Elevated Throughput Synthesis of Enureas Advanced by Microwave Irradiated Pd-Catalyzed C-N Coupling of Alkenyl Nonaflates

A novel and flexible synthetic approach to enureas is described. This convenient method has been developed for the Pd-catalyzed C-N coupling reaction of alkenyl nonaflates with a variety of ureas. A ferrocene based phosphine ligand, Joshiphos appeared noticeable as the most dynamic catalyst and K3PO4 in t-BuOH was established to be the most favorable base-solvent combination for the reaction. This catalyst system displayed amazing functional group tolerance and assigned quick synthesis of the entire series of enureas in excellent yields.