Non-Cross-Linked Polystyrene Supported Cyclosulfamide as a New Chiral Auxiliary for Asymmetric Aldol Reactions

The synthesis of a new non-cross-linked polystyrene supported cyclosulfamide chiral auxiliary is described. Asymmetric aldol reactions using this auxiliary proceeded with good yields and excellent stereoselectivities, which were comparable with those observed by using non-supported cyclosulfamide chiral auxiliary. Furthermore, recovery and recycling of this polymer supported chiral auxiliary have been successfully achieved without appreciable reduction in the yield or stereoselectivity.