Oxazolidin-2-one Ring, a Popular Framework in Synthetic Organic Chemistry: Part 1. The Construction of the Oxazolidin-2-one Ring

G. Zappia; E. Gacs-Baitz; G. Delle Monache; D. Misiti; L. Nevola; B. Botta

doi:10.2174/157017907779981552

ISSN: 1570-1794
E-ISSN: 1875-6271

Oxazolidin-2-one Ring, a Popular Framework in Synthetic Organic Chemistry: Part 1. The Construction of the Oxazolidin-2-one Ring
Authors: G. Zappia¹, E. Gacs-Baitz², G. Delle Monache³, D. Misiti⁴, L. Nevola⁵ and B. Botta⁶
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¹ Ist. di Chimica Farmaceutica, Università degli Studi di Urbino “Carlo Bo”, P.za del Rinascimento 6, 61029 Urbino Italy. ² Ist. di Chimica Farmaceutica, Università degli Studi di Urbino “Carlo Bo”, P.za del Rinascimento 6, 61029 Urbino Italy. ³ Ist. di Chimica Farmaceutica, Università degli Studi di Urbino “Carlo Bo”, P.za del Rinascimento 6, 61029 Urbino Italy. ⁴ Ist. di Chimica Farmaceutica, Università degli Studi di Urbino “Carlo Bo”, P.za del Rinascimento 6, 61029 Urbino Italy. ⁵ Ist. di Chimica Farmaceutica, Università degli Studi di Urbino “Carlo Bo”, P.za del Rinascimento 6, 61029 Urbino Italy. ⁶ Ist. di Chimica Farmaceutica, Università degli Studi di Urbino “Carlo Bo”, P.za del Rinascimento 6, 61029 Urbino Italy.
Source: Current Organic Synthesis, Volume 4, Issue 1, Feb 2007, p. 81 - 135
DOI: https://doi.org/10.2174/157017907779981552
- Available online: 01 Feb 2007

Abstract

The 1,3-oxazolidin-2-one nucleus is a popular heterocycle framework in synthetic organic chemistry, as well as in medicinal chemistry. This paper deals with the huge number of synthetic approaches addressed to the construction of this five-member ring, with a particular care for the mechanistic and stereochemical outcome.

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2007-02-01

2025-09-04

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Article Type: Research Article

Keyword(s): 1,2-aminoalcohol; 1,3-Oxazolidin-2-one; amino-acids; Curtius- rearrangement; cyclocarbamation reactions; epoxides and aziridines

Oxazolidin-2-one Ring, a Popular Framework in Synthetic Organic Chemistry: Part 1. The Construction of the Oxazolidin-2-one Ring

Abstract

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