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- ISSN: 1570-1794
- E-ISSN: 1875-6271
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Synthetic Studies on N-Methylwelwitindolinone C Isothiocyanate (Welwistatin) and Related Substructures
- Source: Current Organic Synthesis, Volume 1, Issue 1, Jan 2004, p. 65 - 82
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- 01 Jan 2004
Abstract
N-Methylwelwitindolinone C isothiocyanate (welwistatin), isolated from the blue-green alga Hapalosiphon welwitschii, is a potent MDR inhibitor. This review deals with synthetic efforts aimed at welwistatin itself or its fragments, together with work concerning the bicyclo[4.3.1]decane and cyclohepta[cd]indole systems, which are related to the CD and ABC fragments of the natural product.
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