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- ISSN: 1871-5273
- E-ISSN: 1996-3181
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Neurological Disorders in Mice Lacking Glycogenes that are Mainly Expressed in Brain
- Source: CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders), Volume 5, Issue 4, Aug 2006, p. 441 - 444
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- 01 Aug 2006
Abstract
At the present time, 160 human glycogenes encoding glycosyltransferases and sulfotransferases, which add sulfate to carbohydrates, have been cloned and analyzed for their substrate specificity. Mice have almost all genes orthologous to them, and some are specifically expressed in neuronal tissues. In this review, neurological disorders of mice deficient for the glycogenes that synthesize interesting carbohydrate epitopes in neuronal tissues are described and summarized.
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