Novel Treatments of Schizophrenia: Targeting the Neurotensin System

B. Kinkead; C. B. Nemeroff

doi:10.2174/187152706776359655

ISSN: 1871-5273
E-ISSN: 1996-3181

Novel Treatments of Schizophrenia: Targeting the Neurotensin System
Authors: B. Kinkead¹ and C. B. Nemeroff²
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¹ Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Suite 4000 WMRB, 101 Woodruff Circle, Atlanta, GA 30322, USA. ² Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Suite 4000 WMRB, 101 Woodruff Circle, Atlanta, GA 30322, USA.
Source: CNS & Neurological Disorders - Drug Targets, Volume 5, Issue 2, Apr 2006, p. 205 - 218
DOI: https://doi.org/10.2174/187152706776359655
- Available online: 01 Apr 2006

Abstract

Evidence implicating neural circuits that utilize the neuropeptide transmitter neurotensin (NT) in the pathophysiology of schizophrenia and in the mechanism of action of antipsychotic drugs has previously been reviewed. The majority of evidence, taken together, supports the development of NT receptor agonists as novel antipsychotic drugs. This review comprehensively describes the NT receptor subtypes, discusses the development of NT receptor agonists and the behavioral effects of currently available NT receptor agonists. The compilation of data suggests that NT receptor agonists may represent a novel class of antipsychotic drugs for the treatment of schizophrenia.

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2006-04-01

2025-11-01

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Article Type: Research Article

Keyword(s): Antipsychotic drug; neuromedin N; peptide; schizophrenia; xenin

Novel Treatments of Schizophrenia: Targeting the Neurotensin System

Abstract

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