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image of Neurosarcoidosis - Epidemiological, Clinical, Diagnostic, and Therapeutic Aspects: A Systematic Review

Abstract

Introduction

Neurosarcoidosis is a rare and severe manifestation of sarcoidosis, whose natural history still lacks a comprehensive and theoretical understanding. Therefore, we aimed to conduct a qualitative systematic review of the literature on the clinical-epidemiologic, diagnostic, and therapeutic assessment of patients with neurosarcoidosis.

Methods

A qualitative systematic literature review was conducted in accordance with the PRISMA protocol. The search was conducted between January 1954 and December 2024 in the following databases: PubMed, Scopus, Web of Science, CAPES Journal Portal, and the Virtual Health Library (VHL). Articles were selected if they had at least one of the selected descriptors in the title or abstract, were written in English, Portuguese, or Spanish, and dealt with the clinical-epidemiologic, diagnostic, and therapeutic aspects of neurosarcoidosis. Review articles, experimental studies, and short communications were excluded from the analysis.

Results

Seventy-four articles with 551 cases of neurosarcoidosis were included. The majority of studies were case reports, followed by cohort studies conducted in European countries. The methodological quality of most studies was “good”.

Discussion

Patients with neurosarcoidosis are primarily women Caucasian ethnicity with a mean age of 43.5 years. The disease most commonly involves the cranial nerves (especially cranial nerve II), followed by aseptic meningitis, panhypopituitarism, ocular changes, and diabetes insipidus. The most common laboratory findings were cerebrospinal fluid abnormalities, hypogonadotropic hypogonadism, hyperprolactinemia, and hypothyroidism. The most common neuroimaging changes were meningeal enhancement and pituitary destruction. The treatment of choice was glucocorticoids in conjunction with or without immunosuppressants, with methotrexate and azathioprine being the most commonly used.

Conclusion

This review identified that manifestations such as cranial nerve alterations, aseptic meningitis, and pituitary infiltrations are frequent patterns in neurosarcoidosis, generally associated with laboratory and imaging findings that aid in the diagnosis. Systematizing these data provides a broad view of the disease and may contribute to early diagnosis and effective therapy. Nevertheless, longitudinal studies with larger samples are needed to better understand its natural history and clinical outcomes in the medium and long term.

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2025-09-29

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References

  1. Besnier E. Lupus pernio of the face: Symmetrical fungal synovitis of the upper extremities. Ann. Dermatol. Syphiligr. 1889 10 333 336
    [Google Scholar]
  2. Nagai S. Izumi T. Bronchoalveolar lavage. Still useful in diagnosing sarcoidosis? Clin. Chest Med. 1997 18 4 787 797 10.1016/S0272‑5231(05)70418‑4 9413658
    [Google Scholar]
  3. Siltzbach L.E. Sharma O.P. Hosoda Y. Current thoughts on the epidemiology and etiology of sarcoidosis. Am. J. Med. 1965 39 3 361 368 10.1016/0002‑9343(65)90205‑6 14338289
    [Google Scholar]
  4. Statement on Sarcoidosis Am. J. Respir. Crit. Care Med. 1999 160 2 736 755 10.1164/ajrccm.160.2.ats4‑99 10430755
    [Google Scholar]
  5. Mouta A.A.N. De Sousa J.H.G. Pacífico D.S.S. Challenges in the diagnosis of sarcoidosis: A case report. Braz J Dev 2023 9 8 23312 23321 10.34117/bjdv9n8‑014
    [Google Scholar]
  6. Ungprasert P. Carmona E.M. Utz J.P. Ryu J.H. Crowson C.S. Matteson E.L. Epidemiology of Sarcoidosis 1946-2013. Mayo Clin. Proc. 2016 91 2 183 188 10.1016/j.mayocp.2015.10.024 26727158
    [Google Scholar]
  7. Joubert B. Chapelon-Abric C. Biard L. Association of prognostic factors and immunosuppressive treatment with long-term outcomes in neurosarcoidosis. JAMA Neurol. 2017 74 11 1336 1344 10.1001/jamaneurol.2017.2492 29052709
    [Google Scholar]
  8. Van Hoye G. Willekens B. Vanden Bossche S. Morrens M. Van Den Eede F. Case report: Psychosis with catatonia in an adult man: A presentation of neurosarcoidosis. Front. Psychiatry 2024 15 1276744 10.3389/fpsyt.2024.1276744 38501088
    [Google Scholar]
  9. Guziejko K. Minarowski Ł, Piłaszewicz-Puza A, Szumera-Ciećkiewicz A, Mróz RM. Multiorgan sarcoidosis as a diabetes insipidus mask. Endocrinol. Diabetes Metab. Case Rep. 2022 2022 22 0266 10.1530/EDM‑22‑0266 36469020
    [Google Scholar]
  10. Kidd D.P. Neurosarcoidosis: clinical manifestations, investigation and treatment. Pract. Neurol. 2020 20 3 199 212 10.1136/practneurol‑2019‑002349 32424017
    [Google Scholar]
  11. Bihan H. Christozova V. Dumas J.L. Sarcoidosis. Medicine (Baltimore) 2007 86 5 259 268 10.1097/MD.0b013e31815585aa 17873755
    [Google Scholar]
  12. Gelfand J.M. Bradshaw M.J. Stern B.J. Infliximab for the treatment of CNS sarcoidosis. Neurology 2017 89 20 2092 2100 10.1212/WNL.0000000000004644 29030454
    [Google Scholar]
  13. Jha S. Pendyala S.K. Tiwari M. Neuro-sarcoidosis with isolated optic neuropathy: Unmasking the chameleon. Egypt. J. Intern. Med. 2024 36 1 55 10.1186/s43162‑024‑00322‑8
    [Google Scholar]
  14. Mortensen J. Loft A. Baslund B. 18F-fluoro-deoxyglucose PET for monitoring treatment in sarcoidosis. Clin. Respir. J. 2007 1 2 124 126 10.1111/j.1752‑699X.2007.00035.x 20298294
    [Google Scholar]
  15. Smith D. Cullen M.J. Two cases of hypothalamic-pituitary sarcoidosis. J. R. Soc. Med. 2005 98 4 167 169 10.1177/014107680509800410 15805561
    [Google Scholar]
  16. Murialdo G. Tamagno G. Endocrine aspects of neurosarcoidosis. J. Endocrinol. Invest. 2002 25 7 650 662 10.1007/BF03345093 12150344
    [Google Scholar]
  17. Féry F. Plat L. van de Borne P. Cogan E. Mockel J. Impaired counterregulation of glucose in a patient with hypothalamic sarcoidosis. N. Engl. J. Med. 1999 340 11 852 856 10.1056/NEJM199903183401105 10080848
    [Google Scholar]
  18. Pompilian V.M. Stoichitoiu L.E. Caraiola S. Balanescu P. Ionescu R. Severe hyponatremia revealing neurosarcoidosis. Romanian Journal of Rheumatology 2018 27 2 90 93 10.37897/RJR.2018.2.7
    [Google Scholar]
  19. Schilke E.D. Remoli G. Cutellé C. Corticosteroid treatment for acute hydrocephalus in neurosarcoidosis: A case report. J. Med. Case Rep. 2024 18 1 53 10.1186/s13256‑024‑04359‑9 38347580
    [Google Scholar]
  20. Matos T Costa C Vale S Bugalho MJ SAT-237 isolated hypogonadotropic hypogonadism in a male with sarcoidosis. J Endocr Soc 2020 4 SAT-237.(Suppl. 1) 10.1210/jendso/bvaa046.964
    [Google Scholar]
  21. Ferreira A. Bastos F. Nunes da Silva T. Cordeiro M. Portugal J. SUN-428 neurosarcoidosis: A rare cause of hypothalamic-pituitary dysfunction. J. Endocr. Soc. 2019 3 SUN-428 10.1210/js.2019‑SUN‑428
    [Google Scholar]
  22. de Waard W.I.Q. van Battum P.L.H. Mostard R.L.M. Central diabetes insipidus due to sarcoidosis. Sarcoidosis Vasc. Diffuse Lung Dis. 2017 34 2 191 193 10.36141/svdld.v34i2.5439 32476843
    [Google Scholar]
  23. Jussen D. Musahl C. Scheil-Bertram S. Wernecke K. Horn P. Krenzlin H. A rare case of isolated cerebral sarcoidosis presenting as suprasellar mass lesion with salt-wasting hypopituitarism. J. Neurol. Surg. Rep. 2015 76 1 e140 e145 10.1055/s‑0035‑1549310 26251792
    [Google Scholar]
  24. Akyildiz E. Yalcin M. Sever F. Semiz H. Kobak S. Hyponatremia as presentation in a patient with neurosarcoidosis. Reumatol. Clín. 2017 13 6 349 351 10.1016/j.reuma.2016.08.004 27720411
    [Google Scholar]
  25. Titlić M, Dolić K, Besenski N. Mild cognitive disorder as clinical manifestation of pituitary stalk neurosarcoidosis: Case report. Acta Clin. Croat. 2011 50 4 581 587 22649890
    [Google Scholar]
  26. Lipnick R.N. Hung W. Pandian M.R. Neurosarcoidosis presenting as secondary amenorrhea in a teenager. J. Adolesc. Health 1993 14 6 464 467 10.1016/1054‑139X(93)90119‑A 8241204
    [Google Scholar]
  27. Forrest A. PSAT053 an unusual case of central adrenal insufficiency following the diagnosis of presumed neuro-sarcoidosis. J Endocr Soc 2022 6 A111-1.(Suppl. 1) 10.1210/jendso/bvac150.226
    [Google Scholar]
  28. Solis J.G. Olascoaga Lugo A. Rodríguez Florido M.A. Sandoval Bonilla B.A. Malagón Rangel J. Neurosarcoidosis presentation as adipsic diabetes insipidus secondary to a pituitary stalk lesion and association with anti-NMDA receptor antibodies. Case Rep. Neurol. Med. 2020 2020 1 5 10.1155/2020/7956350 32670647
    [Google Scholar]
  29. Alsahwi N. Blavo D. Karanchi H. Systemic sarcoidosis with hypercalcaemia, hypothalamic-pituitary dysfunction and thyroid involvement. BMJ Case Rep. 2016 2016 bcr2016216696 10.1136/bcr‑2016‑216696 27495178
    [Google Scholar]
  30. Non L. Brito D. Anastasopoulou C. Neurosarcoidosis-associated central diabetes insipidus masked by adrenal insufficiency. BMJ Case Rep. 2015 2015 bcr2014206390 10.1136/bcr‑2014‑206390
    [Google Scholar]
  31. Sarva H. Chapman R. Omoregie E. Abrams C. The challenge of profound hypoglycorrhachia: two cases of sarcoidosis and review of the literature. Clin. Rheumatol. 2011 30 12 1631 1639 10.1007/s10067‑011‑1834‑y 21870035
    [Google Scholar]
  32. Prayson R.A. Biopsy proven pituitary sarcoidosis presenting as a possible adenoma. J. Clin. Neurosci. 2016 34 217 218 10.1016/j.jocn.2016.05.033 27452130
    [Google Scholar]
  33. Alfares K. Han H.J. Neurosarcoidosis-Induced Panhypopituitarism. Cureus 2023 15 8 43169 10.7759/cureus.43169 37692696
    [Google Scholar]
  34. Jomaa R. Sfar M.H. Mhenni S.Y. Isolated neurosarcoidosis revealed by diabetes insipidus, visual loss and diplopia in a child patient: A diagnostic problem. Clin. Pediatr. Endocrinol. 2009 18 1 51 54 10.1297/cpe.18.51 24790380
    [Google Scholar]
  35. Tanaka K. Yamamoto M. Okazaki K. Yamaguchi T. Sugimoto T. Partial improvement of anterior pituitary deficiency following steroid treatment in a patient with neurosarcoidosis accompanied by central diabetes insipidus. Intern. Med. 2012 51 16 2175 2179 10.2169/internalmedicine.51.6957 22892499
    [Google Scholar]
  36. Namba S. Yokota H. Mukai H. Neurosarcoidosis with enlargement of the dorsal root ganglia: A case report. Radiol. Case Rep. 2024 19 5 1718 1721 10.1016/j.radcr.2024.01.032 38384707
    [Google Scholar]
  37. Erbatur NH Koç G Mehlika Kuşkonmaz Ş, Çulha C. Hypothalamic involvement of sarcoidosis presenting with behavioral disorder. JCEM Case Rep 2023 1 Suppl 1 luac014.041 10.1210/jcemcr/luac014.041
    [Google Scholar]
  38. Liu E. Rohr A. AlMehthel M. Neurosarcoidosis presenting with hypopituitarism. BMJ Case Rep. 2020 13 10 235077 10.1136/bcr‑2020‑235077 33012710
    [Google Scholar]
  39. Ach T. Ben Yahia W. Halloul I. Sghaier F. Atig A. Neurosarcoidosis-induced hypophysitis mimicking pituitary macroadenoma. Cureus 2023 15 6 39865 10.7759/cureus.39865 37404438
    [Google Scholar]
  40. Carbone R.G. Penna D. Monselise A. Puppo F. Systemic sarcoidosis with pituitary adenoma. J. Clin. Imaging Sci. 2022 12 32 32 10.25259/JCIS_43_2022 35769093
    [Google Scholar]
  41. Aloizou A.M. Gabriel T.A. Lukas C. Gold R. Motte J. Aseptic meningitis with recurrent headache episodes, vomiting, and central fever as first manifestation of isolated neurosarcoidosis: A case report. BMC Neurol. 2024 24 1 299 10.1186/s12883‑024‑03794‑x 39198811
    [Google Scholar]
  42. Imsirovic B. Guso E. Omerhodzic I. Tawil A. Merhemic Z. Neurosarcoidosis - the role of magnetic resonance imaging in diagnostics. Acta Inform. Med. 2023 31 1 73 75 10.5455/aim.2023.31.73‑75 37038484
    [Google Scholar]
  43. Borawski B. Kuca P. Zieliński G, Maksymowicz M, Witek P. Pathologically-confirmed isolated hypothalamo-pituitary sarcoidosis refractory to pulse-dose glucocorticoids and successfully treated with methotrexate. Acta Endocrinol. 2022 18 2 244 249 10.4183/aeb.2022.244 36212266
    [Google Scholar]
  44. De Temmerman L. Van Weehaeghe D. Laureys G. Neurosarcoidosis presenting as longitudinally extensive transverse myelitis with limbic encephalitis. Acta Neurol. Belg. 2024 124 6 2013 2016 10.1007/s13760‑024‑02599‑6 38987408
    [Google Scholar]
  45. Kidd D.P. Jabeen F. Galloway M. Neuropathological evidence for neurosarcoidosis is more widespread than imaging suggests. Acta Neurol. Belg. 2024 124 5 1617 1621 10.1007/s13760‑024‑02576‑z 38762698
    [Google Scholar]
  46. Alam T Thomas S Diabetes insipidus secondary to sarcoidosis presenting with caseating granuloma. BMJ Case Rep 2011 2011 1 bcr0120113702 10.1136/bcr.01.2011.3702
    [Google Scholar]
  47. Cardona-Cardona A.F. Mumtaz S. Balistreri L. Bilateral lumbosacral plexopathy as the initial manifestation of systemic sarcoidosis: A case report. Cureus 2024 16 2 54086 10.7759/cureus.54086 38487149
    [Google Scholar]
  48. Tam R. Howard S. Jimenez-Artiles M. Sharma M. Makdisy F. An atypical presentation of a patient with neurosarcoidosis: A case report. Cureus 2024 16 8 68229 10.7759/cureus.68229 39347306
    [Google Scholar]
  49. King N. Rami Reddy M.V.S.R. Waack A. Hoyt A. Schroeder J. A case of suspected neurosarcoidosis evading diagnosis with cervical biopsy. Cureus 2024 16 6 62540 10.7759/cureus.62540 39022493
    [Google Scholar]
  50. Oye M. Chahin M. Krishnan N. Reddy P. Neurosarcoidosis] manifesting as panhypopituitarism. Clin. Case Rep. 2019 7 12 2472 2475 10.1002/ccr3.2521 31893082
    [Google Scholar]
  51. Jung H.J. Mikdashi J. Systemic sarcoidosis with neurosarcoidosis features as a risk factor for multifocal osteonecrosis. Cureus 2024 16 8 66791 10.7759/cureus.66791 39268259
    [Google Scholar]
  52. Deshpande N. Kanelidis A.J. Nguyen A. New-onset neurosarcoidosis following heart transplant for cardiac sarcoidosis. JACC. Case Rep. 2024 29 11 102358 10.1016/j.jaccas.2024.102358 38765201
    [Google Scholar]
  53. Gopal K. Howard J. Ramaraj S. Shroff A.H. Gamard C. An unusual presentation of neurosarcoidosis in a 64-year-old man: A case report. Cureus 2024 16 5 60146 10.7759/cureus.60146 38864033
    [Google Scholar]
  54. Arle J.E. Judkins A.R. Kotapka M.J. Neurosarcoidosis presenting in the pituitary gland with normal endocrine studies. Skull Base 1999 9 2 149 153 10.1055/s‑2008‑1058162 17171131
    [Google Scholar]
  55. Hwang J.K. Cho J.H. Park S.Y. A case of possible neurosarcoidosis presenting as intractable headache and panhypopituitarism. Case Rep. Endocrinol. 2013 2013 1 4 10.1155/2013/816236 23991342
    [Google Scholar]
  56. Chaubey M. Meena K. Singh T. Neurosarcoidosis: An under-diagnosed cause of myelopathy. J. Family Med. Prim. Care 2024 13 5 2157 2160 10.4103/jfmpc.jfmpc_987_23 38948561
    [Google Scholar]
  57. Kumar A. Bai R. Sanjna F. Longitudinally extensive transverse myelitis as an initial manifestation of sarcoidosis: A rare case and its management. Clin. Case Rep. 2024 12 7 9135 10.1002/ccr3.9135 38979085
    [Google Scholar]
  58. Shono T. Tamai M. Kobayashi M. Neurosarcoidosis with spinal root pain as the first symptom. Intern. Med. 2004 43 9 873 877 10.2169/internalmedicine.43.873 15497529
    [Google Scholar]
  59. Inaba H. Suzuki S. Shigematsu S. Kobayashi S. Nishio S. Hashizume K. Spontaneous remission of diabetes insipidus due to CNS sarcoidosis. Intern. Med. 2009 48 4 225 229 10.2169/internalmedicine.48.1583 19218773
    [Google Scholar]
  60. Lawton F.G. Beardwell C.G. Shalet S.M. Daws R.A. Hypothalamic-pituitary disease as the sole manifestation of sarcoidosis. Postgrad. Med. J. 1982 58 686 771 772 10.1136/pgmj.58.686.771 7170286
    [Google Scholar]
  61. Salm R. Familial sarcoidosis terminating as neurosarcoidosis. Postgrad. Med. J. 1969 45 528 668 674 10.1136/pgmj.45.528.668 5358384
    [Google Scholar]
  62. Owen T.K. Henneman J. Diffuse sarcoidosis associated with hypopituitarism and terminal renal failure. BMJ 1954 2 4897 1141 1143 10.1136/bmj.2.4897.1141 13209066
    [Google Scholar]
  63. Serova N.K. Shkarubo A.N. Tropinskaya O.F. Eliseeva N.M. Shishkina L.V. Neurosarcoidosis of the anterior visual pathway (a case report and literature review). Vopr. Neirokhir. 2019 83 4 97 103 10.17116/neiro20198304197 31577275
    [Google Scholar]
  64. Sato N. Sze G. Kim J.H. Cystic pituitary mass in neurosarcoidosis. AJNR Am. J. Neuroradiol. 1997 18 6 1182 1185 9194448
    [Google Scholar]
  65. Tsao C.Y. Lo W.D. Rusin J.A. Henwood M.J. Boue D.R. Isolated neurosarcoidosis presenting as headache and multiple brain and spinal cord lesions mimicking central nervous system metastases. Brain Dev. 2007 29 8 514 518 10.1016/j.braindev.2006.12.011 17307323
    [Google Scholar]
  66. Niedzialkowska E Blazin T Shelden D Buras ED Neurosarcoidosis with panhypopituitarism: Two cases and literature review. JCEM Case Reports 2024 2 8 luae141 10.1210/jcemcr/luae141 39108604
    [Google Scholar]
  67. Yang I. Delpolyi A. Sughrue M.E. Rubenstein J. Bollen A.W. Parsa A.T. Sarcoidosis of the pineal gland: An unusual presentation of neurosarcoidosis. J. Neurooncol. 2009 91 1 113 116 10.1007/s11060‑008‑9687‑1 18759061
    [Google Scholar]
  68. Villacis-Nunez D.S. Thakral A. Pituitary sarcoidosis in a pediatric patient successfully treated with adalimumab and methotrexate. J. Investig. Med. High Impact Case Rep. 2021 9 23247096211012191 10.1177/23247096211012191 33928822
    [Google Scholar]
  69. Ogawa Y. Tominaga T. Ikeda H. Neurosarcoidosis manifesting as tremor of the extremities and severe hypopituitarism: case report. Neurol. Med. Chir. 2008 48 7 314 317 10.2176/nmc.48.314 18654052
    [Google Scholar]
  70. Matsunaga S. Kimura Y. Watanabe N. Akiyama Y. Mikuni N. Neurosarcoidosis complicated by noncommunicating hydrocephalus with atypical presentation, diagnosed and treated with endoscopic surgery: A case report. NMC Case Rep. J. 2024 11 0 243 247 10.2176/jns‑nmc.2023‑0298 39295787
    [Google Scholar]
  71. Miyoshi T. Otsuka F. Takeda M. An elderly patient with sarcoidosis manifesting panhypopituitarism with central diabetes insipidus. Endocr. J. 2007 54 3 425 430 10.1507/endocrj.K06‑161 17446653
    [Google Scholar]
  72. Tabuena R.P. Nagai S. Handa T. Diabetes insipidus from neurosarcoidosis: Long-term follow-up for more than eight years. Intern. Med. 2004 43 10 960 966 10.2169/internalmedicine.43.960 15575248
    [Google Scholar]
  73. Neves M. Aguiar P. Belsuzarri T. Neurosarcoidosis associated with psychiatric symptoms: Case report. Braz. Neurosurg. 2017 36 3 185 189 10.1055/s‑0037‑1606290
    [Google Scholar]
  74. Langrand C. Bihan H. Raverot G. Hypothalamo-pituitary sarcoidosis: A multicenter study of 24 patients. QJM 2012 105 10 981 995 10.1093/qjmed/hcs121 22753675
    [Google Scholar]
  75. Zajicek J.P. Scolding N.J. Foster O. Central nervous system sarcoidosisdiagnosis and management. QJM 1999 92 2 103 117 10.1093/qjmed/92.2.103 10209662
    [Google Scholar]
  76. Al-Hader R. Nofar J. Mohamedelkhair A. Affan M. Schultz L.R. Cerghet M. A comprehensive characterization of patients with spinal cord neurosarcoidosis: A single Center Cross-sectional study of clinical outcomes. J. Clin. Med. 2024 13 17 5069 10.3390/jcm13175069 39274281
    [Google Scholar]
  77. Leonhard S.E. Fritz D. Eftimov F. van der Kooi A.J. van de Beek D. Brouwer M.C. Neurosarcoidosis in a tertiary referral center: A cross-sectional cohort study. Medicine 2016 95 14 3277 10.1097/MD.0000000000003277 27057889
    [Google Scholar]
  78. Berntsson S.G. Elmgren A. Gudjonsson O. Grabowska A. Landtblom A.M. Moraes-Fontes M.F. A comprehensive diagnostic approach in suspected neurosarcoidosis. Sci. Rep. 2023 13 1 6539 10.1038/s41598‑023‑33631‑z 37085608
    [Google Scholar]
  79. Fritz D. Timmermans W.M.C. van Laar J.A.M. Infliximab treatment in pathology-confirmed neurosarcoidosis. Neurol. Neuroimmunol. Neuroinflamm. 2020 7 5 847 10.1212/NXI.0000000000000847 32718952
    [Google Scholar]
  80. Mahmood S. Sallowm Y. Affan M. Schultz L. Cerghet M. Ali A. Radiological features of patients with headache as a presenting symptom of neurosarcoidosis. Headache 2024 64 8 1059 1064 10.1111/head.14738 38780214
    [Google Scholar]
  81. Matias T.B. Cordeiro R.A. Duarte J.A. Immune-mediated hypertrophic pachymeningitis and its mimickers: Magnetic resonance imaging findings. Acad. Radiol. 2023 30 11 2696 2706 10.1016/j.acra.2023.01.017 36882352
    [Google Scholar]
  82. Bradshaw M.J. Pawate S. Koth L.L. Cho T.A. Gelfand J.M. Neurosarcoidosis. Neurol. Neuroimmunol. Neuroinflamm. 2021 8 6 1084 10.1212/NXI.0000000000001084 34607912
    [Google Scholar]
  83. Tamanini J.V.G. Sabino J.V. Cordeiro R.A. The role of MRI in differentiating demyelinating and inflammatory (not infectious) myelopathies. Semin. Ultrasound CT MR 2023 44 5 469 488 10.1053/j.sult.2023.03.017 37555683
    [Google Scholar]
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Neurosarcoidosis - Epidemiological, Clinical, Diagnostic, and Therapeutic Aspects: A Systematic Review
Bentham Science Publishers ; https://doi.org/10.2174/0118715273381216250706103418
/content/journals/cnsnddt/10.2174/0118715273381216250706103418
/content/journals/cnsnddt/10.2174/0118715273381216250706103418
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  • Article Type:     Review Article
Keywords: treatment ; Central nervous system diseases ; sarcoidosis ; systematic review ; neurosarcoidosis ; pituitary gland

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