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2000
Volume 24, Issue 2
  • ISSN: 1871-5273
  • E-ISSN: 1996-3181

Abstract

The prevalence of neurodegenerative diseases has increased with longer life expectancies, necessitating the exploration of novel neuroprotective agents. Tangeretin, a polymethoxylated flavone derived from citrus fruits, has gathered attention for its potential therapeutic effects. This review highlights the neuroprotective properties of tangeretin its antioxidant and anti-inflammatory mechanisms. Tangeretin demonstrates efficacy in mitigating oxidative stress, neuroinflammation, and neuronal damage across various neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, cerebral ischemia, and epilepsy. It shows promise in ameliorating cognitive deficits and memory impairments associated with these diseases. Moreover, tangeretin modulates multiple signalling pathways and protects against neuronal apoptosis, underscoring its potential as a therapeutic agent.

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2024-09-18
2025-09-08

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The Neuroprotective Role of Tangeritin
CNS & Neurological Disorders - Drug Targets (Formerly Current Drug Targets - CNS & Neurological Disorders) 24, 144 (2025); https://doi.org/10.2174/0118715273325789240904065214
/content/journals/cnsnddt/10.2174/0118715273325789240904065214
/content/journals/cnsnddt/10.2174/0118715273325789240904065214
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  • Article Type:     Review Article
Keyword(s): anti-inflammatory; neurodegenerative disorders; neuroprotective; oxidative stress; signalling; Tangeretin

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