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Nanotechnology is driving revolutionary changes across numerous fields, including physics, medicine, and energy. A more effective approach is needed for managing biodegradable waste compared to the current inorganic methods. Organic waste, such as watermelon peel, can be sustainably used to produce nanoparticles. Biodegradable waste benefits society through its natural decomposition processes. Recently, nanoparticles have attracted significant attention due to their unique chemical, physical, and biological properties, as well as their diverse applications across various scientific disciplines. Most conventional methods for synthesizing nanoparticles involve hazardous chemicals or are costly. However, NiO nanoparticles (NiO-NPs), derived from various biological sources, are inexpensive, durable, nontoxic, and environmentally friendly due to their easy availability. These nanoparticles exhibit a range of biochemical activities, including antimicrobial, anticancer, antioxidant, antibacterial, antifungal, anti-inflammatory, antidiabetic, and anti-larvicidal effects. This review discusses different green synthesis methods for NiO-NPs and recent findings regarding their therapeutic applications. Additionally, this study highlights future opportunities for developing green NiO-NPs as effective therapeutic agents.
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