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image of Preparation and Characterization of a Coconut Oil Nanoemulsion for Ellagic Acid Encapsulation

Abstract

Introduction

Ellagic acid, a BCS Class IV drug, suffers from poor solubility and permeability, limiting its therapeutic potential despite its wide pharmacological activities. This study aimed to develop a coconut oil-based Ellagic acid Nanoemulsion (CoEaNe) and evaluate its wound-healing efficacy.

Methods

CoEaNe was prepared using a modified ultrasonication process. Drug loading and entrapment efficiency were assessed UV spectroscopy. Particle size and polydispersity index were measured with a zeta sizer, while particle morphology was examined using Field Emission Scanning Electron Microscopy (FESEM). wound-healing activity was evaluated in the Albino Wistar rat model. Drug release kinetics were analyzed using various mathematical models.

Results

The nanoemulsion exhibited a Z-average of 137.9 nm with spherical morphology and demonstrated zero-order release kinetics. FESEM confirmed uniform spherical particles. , CoEaNe significantly enhanced wound healing, achieving complete closure of burn wounds compared to controls.

Discussion

The research findings highlight the potential of CoEaNe as a promising drug delivery system for poorly soluble BCS Class IV drugs. The enhanced wound-healing effect may be attributed to the optimized particle size, sustained drug release, and improved entrapment efficiency.

Conclusion

Coconut oil-based Ellagic acid Nanoemulsion (CoEaNe) has optimal and favorable physicochemical properties, efficient drug loading, and significant wound-healing efficacy , suggesting its applicability as a novel carrier system for enhancing therapeutic outcomes of poorly soluble drugs.

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2025-10-29
2025-12-04

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/content/journals/cnm/10.2174/0124054615375040251003113615
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Preparation and Characterization of a Coconut Oil Nanoemulsion for Ellagic Acid Encapsulation
Bentham Science Publishers ; https://doi.org/10.2174/0124054615375040251003113615
/content/journals/cnm/10.2174/0124054615375040251003113615
/content/journals/cnm/10.2174/0124054615375040251003113615
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  • Article Type:     Research Article
Keywords: wound healing ; coconut oil nano-emulsion ; good health and well being ; Nano-emulsion ; ellagic acid nano-emulsion ; ellagic acid encapsulation ; coconut oil ; CoEaNe

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