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Abstract

There has been the use of herbal phytopharmaceuticals for the treatment of different diseases but has been challenged by poor solubility and permeability. Nanoparticle delivery systems effectively solve these problems by improving the pharmacokinetics of nanoparticles and easily enhancing their targeting abilities. The current review offers the reader a comprehensive report on recent developments in herbal nanocarriers, including organic and inorganic nanoparticles. Some of the important parameters, including size and geometrical arrangement as well as surface properties, affecting the efficacy of such systems are also described here. Furthermore, the review elaborates on the use of herbal nanoparticles for some diseases, such as cancer, inflammation, and neurological disorders, including new trends and future aspects in the field.

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2025-01-22
2025-09-04
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References

  1. Jadhav N. Powar T. Shinde S. Nadaf S. Herbal nanoparticles: A patent review. Asian J. Pharm. 2014 8 1 58 10.4103/0973‑8398.134101
    [Google Scholar]
  2. Kumar S. Singh A. Kapoor M. Curcumin-loaded nanoparticles for use in treatment of inflammatory conditions. U.S. Patent No. US 11,321,847, 2022
  3. Jin M.Z. Jin W.L. The updated landscape of tumor microenvironment and drug repurposing. Signal Transduct. Target. Ther. 2020 5 1 166 10.1038/s41392‑020‑00280‑x 32843638
    [Google Scholar]
  4. Sun Y. Chiao P. J. Updated landscape of the tumor microenvironment and targeting strategies in an Era of precision medicine. Patient Centered Medicine Sayligil O. IntechOpen Springer 2017 66575 10.5772/66575
    [Google Scholar]
  5. Tsai M.J. Chang W.A. Huang M.S. Kuo P.L. Tumor microenvironment: A new treatment target for cancer. ISRN Biochem. 2014 2014 1 8 10.1155/2014/351959 25937967
    [Google Scholar]
  6. Witz I. P. The tumor microenvironment: The making of a paradigm. Cancer Microenviron. 2009 2 S1 9 17 10.1007/s12307‑009‑0025‑8 19701697
    [Google Scholar]
  7. Wen J. Moloney E.B. Canning A. Donohoe E. Ritter T. Wang J. Xiang D. Wu J. Li Y. Synthesized nanoparticles, biomimetic nanoparticles and extracellular vesicles for treatment of autoimmune disease: Comparison and prospect. Pharmacol. Res. 2021 172 105833 10.1016/j.phrs.2021.105833 34418563
    [Google Scholar]
  8. Fang R.H. Zhang L. Biohybrid nanoparticles for treating arthritis. Nat. Nanotechnol. 2023 18 12 1387 1388 10.1038/s41565‑023‑01503‑2 37884659
    [Google Scholar]
  9. Lin G. Zhang M. Ligand chemistry in antitumor theranostic nanoparticles. Acc. Chem. Res. 2023 56 12 1578 1590 10.1021/acs.accounts.3c00151 37220248
    [Google Scholar]
  10. Overchuk M. Weersink R.A. Wilson B.C. Zheng G. Photodynamic and photothermal therapies: Synergy opportunities for nanomedicine. ACS Nano 2023 17 9 7979 8003 10.1021/acsnano.3c00891 37129253
    [Google Scholar]
  11. Venugopal J. Prabhakaran M. Low S. Choon A. Deepika G. Giri Dev V. Ramakrishna S. Continuous nanostructures for the controlled release of drugs. Curr. Pharm. Des. 2009 15 15 1799 1808 10.2174/138161209788186344 19442191
    [Google Scholar]
  12. Leonti M. Verpoorte R. Traditional mediterranean and european herbal medicines. J. Ethnopharmacol. 2017 199 161 167 10.1016/j.jep.2017.01.052 28179113
    [Google Scholar]
  13. Qi Z. Kelley E. The who traditional medicine strategy 2014–2023. Perspect. Sci. 2014 346 S5 S6
    [Google Scholar]
  14. Cooper G.M. The development and causes of cancer. The Cell: A Molecular Approach 2nd Ed. Sunderland (MA) Sinauer Associates 2000 669
    [Google Scholar]
  15. Kou W.K. Kaohsiung K.W. Water soluble extract from plant of solanum genus and the preparation process thereof, and pharmaceutical composition containing the water-soluble extract. U.S. Patent 20040247715 A1, 2004
  16. Singh C.U. Novel formulation of digitalis glycosides for treating cell-proliferative and other diseases. U.S. Patent 20040082521 A1, 2004
  17. Desai N.P. Soon-Shiong P. De T.K. Combinations and modes of administration of therapeutic agents and combination therapy. U.S. Patent 20070166388 A1, 2007
  18. Desai N.P. Methods and compositions for treating proliferative diseases. U.S. Patent 007780984 B2, 2010
  19. Desai N. P. Soon-Shiong P. Nanoparticles of paclitaxel and albumin in combination with bevacizumab against cancer. U.S. Patent 20100112077A1, 2010
  20. Gorur A. Shanmugasundaram S. Shanmugasundaram S. Preparation of agar bio nanoparticles. IP Patent 376MAS200 3A, 2007
  21. Shanmugasundaram S. Krupakar P. Shanmugasundaram S. Preparation of oligosaccharide bio nanoparticles from Moringa oleifera lam. IP Patent 375MAS2003 A, 2007
  22. Braden A.R. Vishwanatha J.K. Kafka E. Formulation of active agent loaded activated plga nanoparticles for targeted cancer nano-therapeutics. U.S. Patent US20080253961A1, 2018
  23. Liang W. Lou M. Si W. Nano anticancer micelles of vinca alkaloids entrapped in polyethylene glycolated phospholipids. U.S. Patent 20090053293 A1, 2009
  24. Zale S.E. Troiana G. Ali M.M. Hrkach J. Wright J. Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using them. U.S. Patent 20100104655 A1, 2010
  25. Kurzrock R. Li L. Mehata K. Aggarwal B.B. Liposomal curcumin for treatment of cancer. U.S. Patent 007968115 B2, 2011
  26. Rigas B. Mackenzie G. Yu S. Huang L. Zhu R. Nie T. Combination treatments and formulations for cancer. WO Patent 2011130486 A2, 2012
  27. Patel A.R. Tiwari J.K. Velikov K.P. Particles comprising hydrophobic polymer and hydrophobic phenolic compound. WO Patent 2012000757, 2011
  28. Zhang J. Sun J. Li C. Qiao H. Hussain Z. Functionalization of curcumin nanomedicines: A recent promising adaptation to maximize pharmacokinetic profile, specific cell internalization and anticancer efficacy against breast cancer. J. Nanobiotechnol. 2023 21 1 106 10.1186/s12951‑023‑01854‑x 36964547
    [Google Scholar]
  29. Gantar M. Rathinavelu A. Dhandayuthapani S. Combination anti- cancer therapy. WIPO Patent WO2013066864A1, 2013
  30. Liu S. Zaoli J. Cheng Y. Herbal composition and its use in chemotherapy. U.S. Patent 20130101688, 2013
  31. Ranjan A.P. Mukerjee A. Vishwanatha J.K. Helson L. Curcumin-er, a liposomal-plga sustained release nanocurcumin for minimizing qt prolongation for cancer therapy. U.S. Patent US9138411B22015, 2015
  32. Khamar B.M. Gogia A.P. Goda C.C. Shenoy D.B. Shrivastava R.R. Patravale V.B. Modi I.A. Laddha R.N. Khan I.A. Pharmaceutical compositions of curcumin. U.S. Patent US9474727B2, 2016
  33. Ravikanti S. Nano formulation with diverse functional molecules from turmeric and process for preparation of the same. European Patent EP 4 119 126 A1, 2021
  34. Bhatt V. A herbal formulation containing silver nanoparticles with anti-cancer properties. Deutsch Patent DE 202022104339 U1, 2022
  35. Chakraborty A. Gelatin nanoparticle composition loaded with herbal extract for the treatment of skin cancer. Deutsch Patent DE 202023100884 U1, 2023
  36. Champaneria Krishna Dual-targeting polyherbal nanoparticle composition for the treatment of brain tumors. Deutsch Patent DE202024100426U1, 2024
  37. Alzheimer's association. alzheimer's disease facts and figures. 2024 Available from: https://www.alz.org/
  38. Alzheimer's society. symptoms of alzheimer's disease. 2024 Available from: https://www.nhs.uk/conditions/alzheimers-disease/symptoms/
  39. Alzheimer's association. alzheimer's treatments. 2024 Available from: https://www.alz.org/
  40. Nicolas G. Acuña-Hidalgo R. Keogh M.J. Quenez O. Steehouwer M. Lelieveld S. Rousseau S. Richard A.C. Oud M.S. Marguet F. Laquerrière A. Morris C.M. Attems J. Smith C. Ansorge O. Al Sarraj S. Frebourg T. Campion D. Hannequin D. Wallon D. Gilissen C. Chinnery P.F. Veltman J.A. Hoischen A. Somatic variants in autosomal dominant genes are a rare cause of sporadic alzheimer’s disease. Alzheimers Dement. 2018 14 12 1632 1639 10.1016/j.jalz.2018.06.3056 30114415
    [Google Scholar]
  41. Frautschy S.A. Cole G.M. Bioavailable curcuminoids formulations for treating alzheimer’s disease and other age-related disorders. U.S. Patent 20090324703 A1, 2013
  42. Mazed M.A. Mazed S. Nutritional supplement for the prevention of cardiovascular disease, alzheimer’s disease, diabetic, and regulation and reduction of blood sugar and insulin resistance. U.S. Patent 008017147 B2, 2011
  43. DiMauro T.M. Methylated curcumin-resveratrol hybrid molecules for treating cancer. U.S. Patent 008350093 B2, 2013
  44. Kim H.J. Choi E.K. Green tea polyphenol loaded nanoparticles for prevention of alzheimer's disease. World Patent WO 2013/045782, 2013
  45. Patel M. Desai N. Berberine loaded nanoparticles for treatment of alzheimer's disease. U.S. Patent 8,911,982, 2014
  46. Li J. Astaxanthin loaded nanoparticles for treatment of alzheimer's disease. China Patent CN 112,789,456, 2018
  47. Liu N. Ruan J. Li H. Fu J. Nanoparticles loaded with natural medicines for the treatment of alzheimer’s disease. Front. Neurosci. 2023 17 1112435 10.3389/fnins.2023.1112435 37877008
    [Google Scholar]
  48. Gupta SK Controlled-release nano-diffusion delivery systems for cosmetic and pharmaceutical compositions. U.S. Patent 20040208902A1, 2004
  49. Gupta S.K. Ion-pair delivery system for cosmetic and pharmaceutical compositions. U.S. Patent 20040228884 A1, 2004
  50. Nanbu T. Whitening cosmetic composition containing arbutin nanoparticles. U.S. Patent 20090069253 A1, 2009
  51. Schmidt B. Wagner H. Green tea extract loaded nanoparticle delivery system for sunscreens. World Patent WO 2022/078452, 2022
  52. Borowska S. Brzóska M.M. Metals in cosmetics: Implications for human health. J. Appl. Toxicol. 2015 35 6 551 572 10.1002/jat.3129 25809475
    [Google Scholar]
  53. Lee J. Park H. Kim B. Coenzyme q10 loaded nanoparticles for use in anti-aging cosmetics. U.S. Patent 11,380,123, 2023
  54. Wright D.C. Micellar nanoparticles. U.S. Patent 005629021 A, 1997
  55. Bakthavatchalam R. Blum C.A. Brielmann H. Caldwell T.M. Lombaert S.D. Substituted quinazolin-4-ylamine analogues as modulators of capsaicin. WO Patent 2003062209 A2, 2003
  56. Kanazawa K. Water-dispersible nanoparticle which contains blood circulation promoter. U.S. Patent 20090104291 A1, 2009
  57. Chaudhary M. Naithani V. Topical herbal formulation for treatment of acne and skin disorder. U.S. Patent 20110262499 A1, 2011
  58. Leighton H.J. Frangakis G.J. Methods and compositions for treating inflammation of skin. U.S. Patent 20130059019, 2013
  59. Zhao Z. Liu T. Zhu S. Pi J. Guo P. Qi D. Liu Z. Li N. Natural medicine combined with nanobased topical delivery systems: A new strategy to treat psoriasis. Drug Deliv. Transl. Res. 2022 12 6 1326 1338 10.1007/s13346‑021‑01031‑3 34287767
    [Google Scholar]
  60. Patel M. Desai N. Hyaluronic acid-loaded nanoparticles for use in moisturizers. U.S. Patent 8,765,143, 2014
  61. Singh G. Kapoor S. Resveratrol-loaded nanoparticles for use in anti-aging cosmetics. U.S. Patent 10,124,032, 2018
  62. Mamgain A. Kenwat R. Paliwal R. Biopolymer zein nanoparticles loaded with Moringa oleifera extract for improved wound healing activity: Development, qbd based optimization and in vivo study. Int. J. Biol. Macromol. 2024 263 Pt 1 130314 10.1016/j.ijbiomac.2024.130314 38382777
    [Google Scholar]
  63. Maurya R. Singh G. Murthy P.S. Mehrotra S. Singh D. Bhargava B. Pharmaceutical composition containing butea isoflavones for the prevention/treatment of bone disorders and a process for the preparation thereof. WO Patent 2007099432, 2007
  64. Mousa S.A. Qari M.H. Ardawi M.S. Composition and methods of natural products in nano formulations for the prevention and treatment of osteoporosis. U.S. Patent 20110104283 A1, 2011
  65. Kim H.J. Choi E.K. Centella asiatica extracts loaded nanoparticles for use in wound healing cosmetics. World Patent WO 2013/087421, 2013
  66. Li J. Wang Q. Zhang X. Icariin loaded nanoparticles for treatment of osteoporosis. China Patent CN 113,456,789, 2019
  67. Tanaka Y. Sato K. Nakamura A. Astragalus extract loaded nanoparticles for treatment of osteoporosis. European Patent EP 4 012 345, 2012
  68. Schmidt B. Wagner H. Resveratrol loaded nanoparticle system for oral delivery targeting osteoporosis. World Patent WO 2022/112741, 2022
  69. Jones M. Brown S. Lee Y. Genistein loaded nanoparticles for treatment of osteoporosis. U.S. Patent US 11,421,763, 2023
  70. Canham L. Shabir QU. Loni A. Porous materials. U.S. Patent 20110236493A1, 2024
  71. Lee J. Park H. Kim B. Saw palmetto extract loaded nanoparticles for use in hair loss prevention shampoos. U.S. Patent 11,542,317, 2024
  72. Panda P. Mohapatra R. Herbal nanoparticles: A targeted approach for neurodegenerative disorder treatment. J. Drug Target. 2024 23 1 14 10.1080/1061186X.2024.2391913 39133517
    [Google Scholar]
  73. Ai S. Li Y. Zheng H. Zhang M. Tao J. Liu W. Peng L. Wang Z. Wang Y. Collision of herbal medicine and nanotechnology: A bibliometric analysis of herbal nanoparticles from 2004 to 2023. J. Nanobiotechnol. 2024 22 1 140 10.1186/s12951‑024‑02426‑3 38556857
    [Google Scholar]
  74. Gu L. Zhang W. Li J. Method for producing nanoparticles containing ginkgo biloba extract for parkinson's disease treatment. European Patent EP3774580A1, 2012
  75. Chudasama A. Patel R. Shah P. Nanoparticle system for treatment of parkinson’s disease using withania somnifera (ashwagandha) root extract. European Patent EP3625412A1, 2020
  76. Zhang L. Wang J. Chen Y. Neuroprotective benefits of ginseng through nanoparticle encapsulation for parkinson’s disease. European Patent EP4012369A1, 2023
  77. Patel M. Desai N. Keratin peptides loaded nanoparticles for use in hair repair treatments. U.S. Patent 9,320,781, 2016
  78. Gupta R. Sharma P. Singh V. Synergistic formulation of ashwagandha and black seed oil in nanocarriers for neuroprotection in parkinson’s disease. Indian Patent IN408732B1, 2024
  79. Nobuhiro Y. Molecular mechanism of hyperlipidemia and future aspects on the therapy. Jpn. J. Clin. Med. 2001 59 1 170 174 11197850
    [Google Scholar]
  80. Aburdeineh S.G. Aburdeineh H.G. Methods of lowering blood cholesterol via oral fenugreek seed extract compositions. U.S. Patent 20050153001A1, 2005
  81. Clark R.A. Singer A. McMohan M.F. Treatment of ischemic tissue. WO Patent 2011047309 A2, 2011
  82. Medasani M. Divi S.B. Picrorhiza kurroa extract for prevention, elimination and treatment of rna viruses and infection diseases. U.S. Patent 20120148569 A1, 2012
  83. Schmidt B. Wagner H. Withania somnifera root extract loaded nanoparticle system for use in parkinson's disease. World Patent WO 2021/082374, 2022
  84. Singh A. Verma K. Gupta S. Herbal-based nano emulsion system containing flaxseed oil for hyperlipidaemia treatment. Indian Patent IN409854A1, 2024
  85. Wertz C.F. Ryde N.P. Nanoparticulate compositions having lysozyme as a surface stabilizer. U.S. Patent 007459283 B2, 2008
  86. Chaniyilparamp M.M. Kurup S.S. Nirmala Menon A. Ophthalmic and nasal solutions containing curcuminoid and its metabolites. U.S. Patent 2012/0159762 A1, 2001
  87. Kar S.K. Akhtar F. Ray G. Pandey A.K. Curcumin nanoparticles and methods of producing the same. U.S. Patent 20110190399 A1, 2011
  88. Nair A.K. Parthasarathy K. Gokaraju G.R. Bhuphatiraju K. Somushekara N. Nanappan R. Curcumoids and its metabolites for the application in allergic ocular/nasal conditions. U.S. Patent 2012/0010297 A1, 2012
  89. Xu X. Yu J. Tong S. Zhu Y. Cao X. Formulation of silymarin with high efficacy and prolonged action and the preparation method thereof. U.S. Patent 20110201680 A1, 2011
  90. Mirkin C.A. Giljohann D.A. Daniel W.L. Delivery of therapeutic agents using oligonucleotide-modified nanoparticles as carriers. WO Patent 2011028850 A1, 2011
  91. Jacob C.V. Synergistic composition for enhancing bioavailability of curcumin. U.S. Patent 20120058208 A1, 2012
  92. Payne A.J. Kurien B.T. Scofield R.H. Solubilization of curcuminoid compounds and products thereof. WO Patent 2013078477 A2, 2013
  93. Tengler M. Taskey P. Lockhart D. McMahen R. Composition and methods of making sustained release liquid formulations. U.S. Patent 20130084340, 2013
  94. Verma P. Sharma R. Gupta A. Encapsulation of gingerol-rich ginger extract in solid lipid nanoparticles for enhanced stability and bioavailability. U.S. Patent US20230206775A1, 2023
  95. Reddy A. Kumar R. Singh M. Preparation of curcumin nanoparticles from turmeric (curcuma longa) to enhance solubility and bioavailability. U.S. Patent US20230309876A1, 2023
  96. Sharma P. Verma S. Gupta R. Chitosan-based nanoparticle system for encapsulation of ashwagandha extract to improve stability and bioavailability. U.S. Patent US20240123456A1, 2024
  97. Chen T.D. Nano-particle production. U.S. Patent 20060008498 A1, 2006
  98. Banerjee R. Singh D. Withania somnifera root extract loaded nanoparticles for inhalation delivery targeting pulmonary fibrosis, European Patent EP 4 021 572, 2020
  99. Li J. Park H. Kim B. Astaxanthin loaded nanoparticles for use in a nutraceutical supplement. U.S. Patent US 11,407,23, 2021
  100. Kumar A. Sharma P. Singh R. Encapsulation of thyme (thymus vulgaris) extract in polymeric nanoparticles for targeting lung. U.S. Patent US20230123456A1, 2023
  101. Ali M. Khan S. Sharma R. Formulation for targeting boswellic acids to the lungs for chronic respiratory diseases. U.S. Patent US20240123457A1, 2024
  102. Priem F. Jacquemond-Collet I. Pharmaceutical composition presenting anti-inflammatory and anti-histaminic properties. EP Patent 2229940A1, 2010
  103. Karnik R. Gu F.X. Cannizzaro C. Khademhosseini A. Langer R.S. Farokhzad O.C. Microfludic synthesis of organic nonoparticles. U.S. patent 20100022680 A1, 2010
  104. Tanaka Y. Sato K. Nakamura A. Resveratrol loaded nanoparticles for use in a nutraceutical promoting cardiovascular health. European Patent EP 4 182 371, 2021
  105. Schmidt B. Wagner H. Green tea extract loaded nanoparticles for use in a nutraceutical promoting cognitive health. World Patent WO 2022/123741, 2022
  106. Martinez L. Smith J. Thompson A. Formulation of resveratrol-loaded nanoparticles for enhanced stability and bioavailability. U.S. Patent US20240198765A1, 2024
  107. Farooq S. Emina B. Narcisa S. Monica R.N. Emina K.S. Eder C.L. Magnetic multifunctional nanomaterials for enhanced transverse chemical and bioanalytical applications – a review. Trends Analyt. Chem. 2024 173 117622 10.1016/j.trac.2024.117622
    [Google Scholar]
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