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image of Solid Lipid Nanoparticles in Nanomedicine and Drug Development

Abstract

SLNs are colloidal drug carriers that have gained significant attention in nanomedicine and drug development due to their unique physicochemical properties, biocompatibility, and ability to enhance the bioavailability of poorly water-soluble drugs. Comprising solid lipids stabilised by surfactants, SLNs offer controlled drug release, protection of labile compounds, and targeted delivery capabilities. This review critically examines experimental studies on SLN structure, classification, formulation, drug targeting, and therapeutic applications. Emphasis is placed on analysing and characterising SLNs based on particle size distribution, drug loading efficiency, release kinetics, cellular uptake, bioavailability enhancement, and surface modifications that improve functionality. The review also highlights key findings demonstrating SLNs’ capacity to enhance pharmacokinetic profiles, reduce toxicity, and facilitate controlled drug release. By synthesising current research, this article aims to provide a comprehensive understanding of the efficacy and limitations of SLNs, offering insights for future optimisation and clinical translation in nanomedicine.

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2026-05-14

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Solid Lipid Nanoparticles in Nanomedicine and Drug Development
Bentham Science Publishers ; https://doi.org/10.2174/0126661454405122251122052422
/content/journals/cms/10.2174/0126661454405122251122052422
/content/journals/cms/10.2174/0126661454405122251122052422
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  • Article Type:     Review Article
Keywords: controlled release ; lipid matrix stabilization ; bioavailability ; nanomedicine ; Solid lipid nanoparticles ; nanoparticles ; targeted drug delivery ; nanotechnology

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