HIV Vaccine and Immunotherapy Approaches

The present review reflects on current strategies for the development of a vaccine or immunotherapy against HIV, the AIDS virus. The phenomena of HIV-infected long-term nonprogressors, the natural host of SIV and HAART-treated, HIV-positive subjects with discordant virus load / CD4 T cell count are discussed. The latter phenomena seem not to hyperactivate the immune system and strategies to specifically suppress HIV-induced immune hyperactivation may help restore a functioning immune system and to further delay or eliminate the onset of AIDS.