Ghrelin: A Gastric Peptide that Regulates Hypothalamic Control of Feeding

H. Yamaguchi; M. Nakazato; K. Kangawa

doi:10.2174/1568015033477758

ISSN: 1568-0150
E-ISSN: 1875-6158

Ghrelin: A Gastric Peptide that Regulates Hypothalamic Control of Feeding
Authors: H. Yamaguchi¹, M. Nakazato² and K. Kangawa³
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¹ Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki 889- 1692, Japan. ² Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki 889- 1692, Japan. ³ Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Miyazaki 889- 1692, Japan.
Source: Current Medicinal Chemistry - Central Nervous System Agents, Volume 3, Issue 3, Sep 2003, p. 177 - 188
DOI: https://doi.org/10.2174/1568015033477758
- Available online: 01 Sep 2003

Abstract

Ghrelin, a novel growth-hormone-releasing peptide isolated from human and rat stomach, is a 28-amino acid peptide with a posttranslational acylation modification that is indispensable for its activity. Ghrelin stimulates secretion of growth hormone, food intake, and body weight gain. This review will focus on the discovery, structural characteristics, tissue distribution, and physiological functions of ghrelin, as well as the regulation of its expression and secretion. Future directions of clinical application of ghrelin as an anabolic peptide are discussed.

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2003-09-01

2025-10-14

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Article Type: Review Article

Keyword(s): Ghrelin

Ghrelin: A Gastric Peptide that Regulates Hypothalamic Control of Feeding

Abstract

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