Antifolates - Past, Present and Future

Aleem Gangjee; Hiteshkumar D. Jain

doi:10.2174/1568011043352803

ISSN: 1568-0118
E-ISSN: 1875-5968

Antifolates - Past, Present and Future
Authors: Aleem Gangjee¹ and Hiteshkumar D. Jain²
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¹ Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282. ² Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282.
Source: Current Medicinal Chemistry - Anti-Cancer Agents, Volume 4, Issue 5, Sep 2004, p. 405 - 410
DOI: https://doi.org/10.2174/1568011043352803
- Available online: 01 Sep 2004

Abstract

This short perspective briefly covers selected aspects of the past, present and future of antifolates in chemotherapy. Both classical and nonclassical analogs currently in the preclinical stage and clinically used agents are covered.

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2004-09-01

2025-09-09

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Article Type: Review Article

Keyword(s): antifolates; classical; dihydrofolate reductase (dhfr); inhibitors; nonclassical; thymidylate synthase (ts)

Antifolates - Past, Present and Future

Abstract

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