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Abstract

Introduction

Amlodipine, a calcium channel blocker, is widely used to treat hypertension, but its effectiveness varies among individuals. Clinicians have observed this variability, and previous research suggests that the Angiotensinogen () genotype influences response to antihypertensive drugs like valsartan. This study investigates the association between the genetic variant and non-genetic anthropometric factors, and the response to amlodipine in essential hypertensive patients at the University of Jordan Hospital.

Methods

A cohort of 46 unrelated Arabic Jordanian patients with essential hypertension was enrolled. Baseline systolic and diastolic blood pressure (BP) readings were recorded before initiating 5 mg amlodipine, with follow-up measurements taken after one month. genotyping was performed using PCR-RFLP, and non-genetic data were obtained from hospital records.

Results

It was found that 28.3% of the tested patients did not respond to amlodipine. The heterozygous genotype showed a significantly ( < 0.05, t-test) lower reduction in the BP compared to wild-type carriers, and its frequency was significantly higher ( < 0.05, ꭙ2 test) among the non-responders to amlodipine. In addition, the average age of the non-responders (41.5±10.3 years) was significantly ( < 0.05, t-test) lower than that of responders (47±10 years) to amlodipine.

Discussion

The heterozygous AGT M235T genotype partially explained inter-individual variation in response to amlodipine among hypertensive patients of Jordanian Arab origin.

Conclusion

It can be concluded that the heterozygous genotype is linked to reduced amlodipine response, while older age is associated with a higher efficacy. However, further multicenter studies with larger cohorts are needed to confirm these findings.

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2026-03-09
2026-05-12

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The Variability of Response to Amlodipine and Its Relation with the Angiotensinogen M235T Genotype among a Sample of Hypertensive Patients in Jordan
Bentham Science Publishers ; https://doi.org/10.2174/011573402139607825112105323
/content/journals/chyr/10.2174/011573402139607825112105323
/content/journals/chyr/10.2174/011573402139607825112105323
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  • Article Type:     Research Article
Keywords: personalized medicine ; hypertension ; Angiotensinogen ; amlodipine response ; genetic variant ; AGT M235T

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