Genetic Abnormalities in Prostate Cancer

Sanjeev Shukla; Gregory T. MacLennan; Susan R. Marengo; Allen D. Seftel; Martin I. Resnick; Sanjay Gupta

doi:10.2174/1389202043490014

ISSN: 1389-2029
E-ISSN: 1875-5488

Genetic Abnormalities in Prostate Cancer
Authors: Sanjeev Shukla¹, Gregory T. MacLennan², Susan R. Marengo³, Allen D. Seftel⁴, Martin I. Resnick⁵ and Sanjay Gupta⁶
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¹ Department of Urology, The James & Eillen Dicke Research Laboratory, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. ² Department of Urology, The James & Eillen Dicke Research Laboratory, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. ³ Department of Urology, The James & Eillen Dicke Research Laboratory, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. ⁴ Department of Urology, The James & Eillen Dicke Research Laboratory, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. ⁵ Department of Urology, The James & Eillen Dicke Research Laboratory, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA. ⁶ Department of Urology, The James & Eillen Dicke Research Laboratory, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.
Source: Current Genomics, Volume 5, Issue 1, Jan 2004, p. 67 - 83
DOI: https://doi.org/10.2174/1389202043490014
- Available online: 01 Jan 2004

Abstract

Molecular genetic mechanisms show diversity during prostate carcinogenesis due to extensive tumor heterogeneity and gene complexity. Understanding the molecular mechanisms involved in initiation and progression of prostate cancer will lead to the development of strategies for early detection, prevention and therapeutic intervention. This review focuses on inheritable and sporadic prostate cancer genes involved in proliferation, metastasis, angiogenesis, tumor suppression, apoptosis, and cellular stress responses.

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2004-01-01

2025-09-04

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Article Type: Review Article

Keyword(s): apoptosis; genetic abnormality; inheritable genes; metastasis; oncogenes; prostate cancer; transcription factors; tumor suppressor genes

Genetic Abnormalities in Prostate Cancer

Abstract

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