Skip to content
2000
image of Development of Biscuits Enriched with Bitter Melon (Momordica charantia L.): Acceptability Test and Its Effect on Blood Glucose Level

Abstract

Introduction

Biscuits are popular snacks consumed by all age groups throughout the world. However, they are generally rich in energy and high glycemic index. Regular consumption of biscuits is associated with an increased risk of obesity and type-2 diabetes mellitus. L., also known as bitter melon, has a hypoglycemic effect; adding it into biscuits may counter the glycemic index of biscuits, thereby keeping the blood glucose level of biscuits consumers normal.

Objectives

The aims of this study were to formulate bitter melon (BM) enriched biscuits and test their acceptability and effect on blood glucose levels (BGL).

Methods

The study consisted of 3 stages, including BM biscuits formulation and production, an acceptability test 30 trained panelists, followed by an experimental stage using pre- and post-test-controlled randomized group design on healthy Wistar rats () to test the effect of BM biscuits on BGL.

Results

The biscuits were made using 0.5% bitter melon flour and 99.5% wheat flour. The BM biscuits were graded as acceptable by 93.3% of the panelists, most of whom rated them with “rather like” for their color and taste. A significant decrease in the BGL was found in after 30 days of the BM biscuits intervention (mean±SD=-9.71±1.15 mg/dL, =0.01) in healthy Wistar rats; conversely, a significant increase in the BGL was found in the control group.

Conclusion

Biscuits enriched with bitter melon flour could be used as an alternative to low glycemic snacks without increasing blood glucose level of healthy Wistar rats.

Loading

Article metrics loading...

/content/journals/cff/10.2174/0126668629354612250116214201
2025-02-14
2025-07-19
Loading full text...

Full text loading...

References

  1. Žuljević S.O. Akagić. Flour-based confectionery as functional food. Functional foods: Phytochemicals and health promoting potential. Arshad M.S. Ahmad M.H. UK IntechOpen 2021 351 377 10.5772/intechopen.95876
    [Google Scholar]
  2. Edwards A. Biscuits and cookies, a global history. London, UK Reaktion Books Ltd. 2019
    [Google Scholar]
  3. Elliott P. Kingwell R. Charter C. The growing consumption of bread and baked goods in Indonesia, an opportunity for Australian wheat. 2019 https://aegic.org.au/wp-content/uploads/2021/03/AEGIC-Bread-and-baked-goods-in-Indonesia.pdf
  4. Nisak A.J. Rachmah Q. Mahmudiono T. Segalita C. Snacking energy dense food related to childhood obesity. J. Nutr. Food Sci. 2018 8 5 725 10.4172/2155‑9600.1000725
    [Google Scholar]
  5. Raditya M. Cathleen F. Raharjo D.E. Kurniawan K. Childhood obesity as a predictor of type 2 diabetes mellitus in adults: A systematic review and meta-analysis. Paediatr. Indones. 2022 62 2 120 129 10.14238/pi62.2.2022.120‑9
    [Google Scholar]
  6. Mboi N. Syailendrawati R. Ostroff S.M. Elyazar I.R.F. Glenn S.D. Rachmawati T. Nugraheni W.P. Ali P.B. Trisnantoro L. Adnani Q.E.S. Agustiya R.I. Laksono A.D. Aji B. Amalia L. Ansariadi A. Antriyandarti E. Ardani I. Ariningrum R. Aryastami N.K. Djunaedi D. Efendi F. Fauk N.K. Ghozali G. Handayani N. Harapan H. Hargono A. Harso A.D.W.I. Ikawati H.D. Indriasih E. Karlina K. Kosen S. Kusnali A. Kusuma D. Lumbantoruan M. Lusiana M. Martini S. meilinda M. Mubasyiroh R. Musadad D.A. Ningrum D.N.A. Nuraini S. Nurlaela N. Pangaribuan H.U. Pawitaningtyas I. Purnomo A. Puspasari H.W. Puspasari N. Rahmawaty S. Rangkuti H. Roosihermiatie B. Rosita T. Rustika R. Samodra Y.L. Samosir J.V. Siswanto S. Smith K.H. Sudaryanto A. Sugianto S. Suparmi S. Susilarini N.K. Tarigan I.U. Ticoalu J.H.V. Trihandini I. Wahidin M. Warouw T.S. Widyastuti R. Wulandari R.D.W.I. Hay S.I. Murray C.J.L. Mokdad A.H. GBD 2019 Indonesia Subnational Collaborators The state of health in Indonesia’s provinces, 1990–2019: A systematic analysis for the Global Burden of Disease Study 2019. Lancet Glob. Health 2022 10 11 e1632 e1645 10.1016/S2214‑109X(22)00371‑0 36240829
    [Google Scholar]
  7. Setiyorini E. Qomaruddin M.B. Wibisono S. Juwariah T. Setyowati A. Wulandari N.A. Sari Y.K. Sari L.T. Complementary and alternative medicine for glycemic control of diabetes mellitus: A systematic review. J. Public Health Res. 2022 11 3 22799036221106582 10.1177/22799036221106582 35911428
    [Google Scholar]
  8. Villa-Caballero L. Morello C.M. Chynoweth M.E. Prieto-Rosinol A. Polonsky W.H. Palinkas L.A. Edelman S.V. Ethnic differences in complementary and alternative medicine use among patients with diabetes. Complement. Ther. Med. 2010 18 6 241 248 10.1016/j.ctim.2010.09.007 21130360
    [Google Scholar]
  9. Pehlivan F.E. Bitter melon: A multifunctional medicinal plant with powerful bioactive compounds. Functional foods: phytochemicals and health promoting potential. Arshad M.S. Ahmad M.H. UK IntechOpen 2021 379 393 10.5772/intechopen.98812
    [Google Scholar]
  10. Joseph B. Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian Pac. J. Trop. Dis. 2013 3 2 93 102 10.1016/S2222‑1808(13)60052‑3
    [Google Scholar]
  11. Tan M.J. Ye J.M. Turner N. Hohnen-Behrens C. Ke C.Q. Tang C.P. Chen T. Weiss H.C. Gesing E.R. Rowland A. James D.E. Ye Y. Antidiabetic activities of triterpenoids isolated from bitter melon associated with activation of the AMPK pathway. Chem. Biol. 2008 15 3 263 273 10.1016/j.chembiol.2008.01.013 18355726
    [Google Scholar]
  12. Jia S. Shen M. Zhang F. Xie J. Recent advances in Momordica charantia: functional components and biological activities. Int. J. Mol. Sci. 2017 18 12 2555 10.3390/ijms18122555 29182587
    [Google Scholar]
  13. Pahlavani N. Roudi F. Zakerian M. Ferns G.A. Navashenaq J.G. Mashkouri A. Ghayour-Mobarhan M. Rahimi H. Possible molecular mechanisms of glucose‐lowering activities of Momordica charantia (karela) in diabetes. J. Cell. Biochem. 2019 120 7 10921 10929 10.1002/jcb.28483 30790347
    [Google Scholar]
  14. Zhou S. Allard P.M. Wolfrum C. Ke C. Tang C. Ye Y. Wolfender J.L. Identification of chemotypes in bitter melon by metabolomics: a plant with potential benefit for management of diabetes in traditional Chinese medicine. Metabolomics 2019 15 8 104 10.1007/s11306‑019‑1565‑7 31321563
    [Google Scholar]
  15. Dixit S. Tiwari S. Investigation of anti-diabetic plants used among the ethnic communities of Kanpur division, India. J. Ethnopharmacol. 2020 253 112639 10.1016/j.jep.2020.112639 32032661
    [Google Scholar]
  16. Bora A.F.M. Kouame K.J.E.P. Li X. Liu L. Pan Y. New insights into the bioactive polysaccharides, proteins, and triterpenoids isolated from bitter melon (Momordica charantia) and their relevance for nutraceutical and food application: A review. Int. J. Biol. Macromol. 2023 231 123173 10.1016/j.ijbiomac.2023.123173 36642359
    [Google Scholar]
  17. Drewnowski A. Gomez-Carneros C. Bitter taste, phytonutrients, and the consumer: A review. Am. J. Clin. Nutr. 2000 72 6 1424 1435 10.1093/ajcn/72.6.1424 11101467
    [Google Scholar]
  18. Islam S. Jalaluddin M. Hettiarachchy N.S. Bio-active compounds of bitter melon genotypes (Momordica charantia L.) in relation to their physiological functions. Funct. Food Health Dis. 2011 1 2 61 74 10.31989/ffhd.v1i2.139
    [Google Scholar]
  19. Snee L.S. Nerurkar V.R. Dooley D.A. Efird J.T. Shovic A.C. Nerurkar P.V. Strategies to improve palatability and increase consumption intentions for Momordica charantia (bitter melon): A vegetable commonly used for diabetes management. Nutr. J. 2011 10 1 78 10.1186/1475‑2891‑10‑78 21794176
    [Google Scholar]
  20. Tan S. Kha T. Parks S. Stathopoulos C. Roach P. Optimising the encapsulation of an aqueous bitter melon extract by spray-drying. Foods 2015 4 3 400 419 10.3390/foods4030400 28231214
    [Google Scholar]
  21. Tan S.P. Kha T.C. Parks S.E. Stathopoulos C.E. Roach P.D. Effects of the spray-drying temperatures on the physiochemical properties of an encapsulated bitter melon aqueous extract powder. Powder Technol. 2015 281 65 75 10.1016/j.powtec.2015.04.074
    [Google Scholar]
  22. Raj N. Priya B. Encapsulation of bitter gourd (Momordica charantia L.) extract by spray drying technique. Biosci. Biotechnol. Res. Asia 2016 13 2 1189 1193 10.13005/bbra/2151
    [Google Scholar]
  23. Wang L. Clardy A. Hui D. Wu Y. Physiochemical properties of encapsulated bitter melon juice using spray drying. Bioact Carbohydr Diet Fibre 2021 26 100278 10.1016/j.bcdf.2021.100278
    [Google Scholar]
  24. Bai J. Zhu Y. Dong Y. Response of gut microbiota and inflammatory status to bitter melon (Momordica charantia L.) in high fat diet induced obese rats. J. Ethnopharmacol. 2016 194 717 726 10.1016/j.jep.2016.10.043 27751827
    [Google Scholar]
  25. Bian H.X. Wu Z.Y. Bao B. Cai J. Wang X. Jiang Y. Liu J. Qu W. 1 H NMR-based metabolic study reveals the improvements of bitter melon ( Momordica charantia ) on energy metabolism in diet-induced obese mouse. Pharm. Biol. 2016 54 12 3103 3112 10.1080/13880209.2016.1211713 27538854
    [Google Scholar]
  26. Cortez-Navarrete M. Martínez-Abundis E. Pérez-Rubio K.G. González-Ortiz M. Méndez-del Villar M. Momordica charantia administration improves insulin secretion in type 2 diabetes mellitus. J. Med. Food 2018 21 7 672 677 10.1089/jmf.2017.0114 29431598
    [Google Scholar]
  27. Shimada T. Kato F. Dwijayanti D.R. Nagata T. Kinoshita A. Okuyama T. Nishizawa M. Mukai E. Bitter melon fruit extract enhances intracellular ATP production and insulin secretion from rat pancreatic β -cells. Br. J. Nutr. 2022 127 3 377 383 10.1017/S0007114521001082 33762029
    [Google Scholar]
  28. Shivanagoudra S.R. Perera W.H. Perez J.L. Athrey G. Sun Y. Jayaprakasha G.K. Patil B.S. Cucurbitane-type compounds from Momordica charantia: Isolation, in vitro antidiabetic, anti-inflammatory activities and in silico modeling approaches. Bioorg. Chem. 2019 87 31 42 10.1016/j.bioorg.2019.02.040 30856374
    [Google Scholar]
  29. Horax R. Hettiarachchy N. Islam S. Total phenolic contents and phenolic acid constituents in 4 varieties of bitter melons (Momordica charantia) and antioxidant activities of their extracts. J. Food Sci. 2005 70 4 C275 C280 10.1111/j.1365‑2621.2005.tb07173.x
    [Google Scholar]
/content/journals/cff/10.2174/0126668629354612250116214201
Loading
/content/journals/cff/10.2174/0126668629354612250116214201
Loading

Data & Media loading...


  • Article Type:
    Research Article
Keywords: blood glucose ; Acceptability ; biscuits ; Wistar rats ; Momordica charantia L
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test