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2000
Volume 21, Issue 3
  • ISSN: 1573-4080
  • E-ISSN: 1875-6662

Abstract

Introduction

is a herbaceous perennial plant belonging to the family Moraceae. It is used in various diseases, ., gastrointestinal disorders, tumours, hypoglycaemia, ulcers, hyperlipidaemia, diabetes, and fungal infections.

Methods

The fruit of the plant was extracted. The total phenolic and total flavonoid content were determined. Following column chromatography, phytoconstituents were isolated and identified by mass spectroscopy, FTIR, and NMR. The antioxidant activity of phytoconstituents was evaluated, and molecular docking studies were performed against the H+K+-ATPase enzyme and H Receptor.

Results

The extract from yielded rich in flavonoids and phenolic content. Isolation of compounds was done and characterized to be rutin and luteolin. The further evaluation of the antioxidant activity of compounds demonstrated significant activity with an IC value indicating strong free radical scavenging activity. Molecular docking studies were performed against the H+K+-ATPase enzyme and H Receptor, revealing that both compounds exhibit high binding affinity and favourable interactions with key sites.

Discussion

The study revealed that fruit extract is a rich source of flavonoids and phenolics, notably rutin and luteolin. These compounds demonstrated strong antioxidant activity through various free radical scavenging assays. Molecular docking suggested their potential as inhibitors of the H+K+-ATPase enzyme and H receptor, indicating antiulcer potential. These findings support the therapeutic relevance of in oxidative stress-related gastric disorders.

Conclusion

The findings suggest that the isolated compounds rutin and luteolin possess potential antioxidant activity and could be a therapeutic target for the H+K+-ATPase enzyme and H Receptor.

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Antioxidant and Molecular Docking Insights of Bioactive Compounds Isolated from Ficus palmata: Targeting H+K+-ATPase Enzyme and H2 Receptor
Curr. Enzym. Inhib. 21, 249 (2025); https://doi.org/10.2174/0115734080373426250509073139
/content/journals/cei/10.2174/0115734080373426250509073139
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  • Article Type:     Research Article
Keyword(s): antioxidant activity; Ficus palmata; H+K+-ATPase enzyme; H2 receptor; luteolin; rutin

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