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2000
Volume 21, Issue 1
  • ISSN: 1573-4080
  • E-ISSN: 1875-6662

Abstract

Background

Diabetes prevalence is progressively rising everywhere, particularly in developing countries. Lichens have evolved into a rich source of innovative bioactive chemicals with their anti-oxidant capabilities, widening the scope of well-documented and effective diabetes treatment.

Objective

The main objectives of this study were to perform alpha-amylase, alpha-glucosidase inhibition analysis, and anti-oxidant of lichen

Methods

Folin Ciocalteu’s reagent was used to determine the total phenolic content for biological activities. The Aluminum trichloride method was used to determine total flavonoid content, and the free radical assay method was used to determine the antioxidant activity of using 2,2-diphenyl-1-picrylhydrazyl (DPPH). Moreover, substrate 2-Chloro-4-nitrophenyl---maltotrioside (CNPG3) and substrate-nitrophenyl---glucopyranose (-NPG) were used for the determination of alpha-amylase and alpha-glucosidase inhibition activities respectively, and molecular docking was performed by Auto Dock Vina.

Results

Total phenolic and flavonoid contents present in were 37.41 ± 2.87 mg GAE/g and 5.53 ± 0.95 mg QE/g, respectively. For anti-oxidant inhibition activity, crude extract of methanol showed an IC value of 15.324 ± 0.80 µg/mL. Furthermore, a methanolic crude extract showed significant inhibition activities against alpha-amylase (IC = 178.50 ± 1.10 µg/mL) and alpha-glucosidase (IC = 76.10 ± 0.91 µg/mL). During analysis, zeorin showed an effective binding affinity with -7.9 kcal/mol, and Atranorin showed -7.4 kcal/mol in the orthosteric site of the protein.

Conclusion

exhibits the potential to impact biological functions, demonstrating antidiabetic properties, as confirmed by molecular docking analysis .

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In vitro Anti-oxidant, Alpha-Amylase, and Alpha-Glucosidase Inhibition Studies of Physica aipolia (Ehrh.ex Humb.) Furnr
Curr. Enzym. Inhib. 21, 40 (2025); https://doi.org/10.2174/0115734080315689240925055031
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  • Article Type:     Research Article
Keyword(s): ADMET; alpha-amylase; alpha-glucosidase; anti-oxidant; molecular docking; Physica aipolia

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