Differentiation of CD8 T Cells in Response to Acute and Chronic Viral Infections: Implications for HIV Vaccine Development

J. D. Miller; D. Masopust; E. J. Wherry; S. Kaech; G. Silvestri; R. Ahmed

doi:10.2174/1568005054201544

ISSN: 1568-0053
E-ISSN: 1875-5852

Differentiation of CD8 T Cells in Response to Acute and Chronic Viral Infections: Implications for HIV Vaccine Development
Authors: J. D. Miller¹, D. Masopust², E. J. Wherry³, S. Kaech⁴, G. Silvestri⁵ and R. Ahmed⁶
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¹ Emory Vaccine Center, Department of Microbiology and Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. ² Emory Vaccine Center, Department of Microbiology and Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. ³ Emory Vaccine Center, Department of Microbiology and Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. ⁴ Emory Vaccine Center, Department of Microbiology and Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. ⁵ Emory Vaccine Center, Department of Microbiology and Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA. ⁶ Emory Vaccine Center, Department of Microbiology and Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Source: Current Drug Targets - Infectious Disorders, Volume 5, Issue 2, Jun 2005, p. 121 - 129
DOI: https://doi.org/10.2174/1568005054201544
- Available online: 01 Jun 2005

Abstract

Successful HIV vaccine strategies will likely require the induction of robust cellular immune responses, in addition to strong humoral responses. Unfortunately, there is no clear molecular definition of an effective HIV-specific CD8 T cell response. In this review, we discuss the differentiation of CD8 T cells in response to acute and chronic viral infections. We then apply concepts derived from these studies to predict the desirable characteristics of HIV-specific CD8 T cell memory.

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2005-06-01

2025-09-10

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Article Type: Review Article

Keyword(s): cd t cells; differentiation; hiv vaccine; immune memory; lcmv

Differentiation of CD8 T Cells in Response to Acute and Chronic Viral Infections: Implications for HIV Vaccine Development

Abstract

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